C
Chia-Lin Tsou
Researcher at University of California, San Francisco
Publications - 23
Citations - 3794
Chia-Lin Tsou is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: CCR2 & Chemokine. The author has an hindex of 16, co-authored 19 publications receiving 3087 citations. Previous affiliations of Chia-Lin Tsou include Gladstone Institutes.
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Journal ArticleDOI
Critical roles for CCR2 and MCP-3 in monocyte mobilization from bone marrow and recruitment to inflammatory sites
Chia-Lin Tsou,Wendy Peters,Yue Si,Sarah Slaymaker,Ara M. Aslanian,Stuart P. Weisberg,Matthias Mack,Israel F. Charo +7 more
TL;DR: It is reported that CC chemokine receptor 2 (CCR2) is highly expressed on a subpopulation of blood monocytes whose numbers are markedly decreased in CCR2(-/-) mice, suggesting that CCR 2 is critical for monocyte egress.
Journal ArticleDOI
Amplification-free detection of SARS-CoV-2 with CRISPR-Cas13a and mobile phone microscopy.
Parinaz Fozouni,Sungmin Son,María Díaz de León Derby,Gavin J. Knott,Gavin J. Knott,Carley N. Gray,Carley N. Gray,Michael V. D’Ambrosio,Chunyu Zhao,Neil A. Switz,G. Renuka Kumar,G. Renuka Kumar,Stephanie I. Stephens,Stephanie I. Stephens,Daniela Boehm,Daniela Boehm,Chia-Lin Tsou,Chia-Lin Tsou,Jeffrey Shu,Jeffrey Shu,Abdul Bhuiya,Maxim Armstrong,Andrew R. Harris,Pei Yi Chen,Pei Yi Chen,Jeannette M. Osterloh,Anke Meyer-Franke,Bastian Joehnk,Keith Walcott,Anita Sil,Charles Langelier,Katherine S. Pollard,Emily D. Crawford,Andreas S. Puschnik,Maira Phelps,Amy Kistler,Joseph L. DeRisi,Jennifer A. Doudna,Daniel A. Fletcher,Melanie Ott +39 more
TL;DR: This work reports the development of an amplification-free CRISPR-Cas13a assay for direct detection of SARS-CoV-2 from nasal swab RNA that can be read with a mobile phone microscope and has the potential to enable rapid, low-cost, point-of-care screening for Sars-Cov-2.
Journal ArticleDOI
Selective chemokine receptor usage by central nervous system myeloid cells in CCR2-red fluorescent protein knock-in mice.
Noah Saederup,Astrid E. Cardona,Kelsey Croft,Makiko Mizutani,Anne C. Cotleur,Chia-Lin Tsou,Richard M. Ransohoff,Israel F. Charo +7 more
TL;DR: These results refine the concept of monocyte subsets, provide mechanistic insight about monocyte entry into the central nervous system, and present a novel model for imaging and quantifying inflammatory myeloid populations.
Journal ArticleDOI
Tumor Necrosis Factor-α-converting Enzyme Mediates the Inducible Cleavage of Fractalkine
TL;DR: It is reported that tumor necrosis factor-α-converting enzyme (TACE) is primarily responsible for the inducible cleavage of FK, and a potentially important link between local generation of potent cytokines and control of the balance between the cell adhesion and chemotactic properties of Fk is identified.
Journal ArticleDOI
Human Placental Cytotrophoblasts Attract Monocytes and Cd56bright Natural Killer Cells via the Actions of Monocyte Inflammatory Protein 1α
Penelope M. Drake,Michael D. Gunn,Israel F. Charo,Chia-Lin Tsou,Yan Zhou,Ling Huang,Susan J. Fisher +6 more
TL;DR: The data suggest the specific conclusion that cytotrophoblasts can attract monocytes and CD56bright NK cells by producing MIP-1α and the more general hypothesis that these cells may organize and act on leukocytes at the maternal–fetal interface.