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Nadine Haase
Researcher at Max Delbrück Center for Molecular Medicine
Publications - 52
Citations - 1126
Nadine Haase is an academic researcher from Max Delbrück Center for Molecular Medicine. The author has contributed to research in topics: Preeclampsia & Pregnancy. The author has an hindex of 14, co-authored 46 publications receiving 669 citations. Previous affiliations of Nadine Haase include Braunschweig University of Technology & University of Duisburg-Essen.
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Journal ArticleDOI
Short-Chain Fatty Acid Propionate Protects From Hypertensive Cardiovascular Damage
Hendrik Bartolomaeus,András Balogh,Mina Yakoub,Susanne Homann,Lajos Markó,Sascha Höges,D. Tsvetkov,D. Tsvetkov,D. Tsvetkov,Alexander Krannich,Sebastian Wundersitz,Sebastian Wundersitz,Ellen G. Avery,Nadine Haase,Kristin Kräker,Lydia Hering,Martina Maase,Kristina Kusche-Vihrog,Maria Grandoch,Jens Fielitz,Stefan Kempa,Maik Gollasch,Maik Gollasch,Zhaxybay Zhumadilov,Samat Kozhakhmetov,Almagul Kushugulova,Kai-Uwe Eckardt,Ralf Dechend,Lars Christian Rump,Sofia K. Forslund,Dominik N. Müller,Johannes Stegbauer,Nicola Wilck +32 more
TL;DR: The data suggest that lifestyle modifications leading to augmented SCFA production could be a beneficial nonpharmacological preventive strategy for patients with hypertensive cardiovascular disease and emphasize an immune-modulatory role of SCFAs and their importance for cardiovascular health.
Journal ArticleDOI
An increased population of regulatory t cells improves the pathophysiology of placental ischemia in a rat model of preeclampsia
Denise C. Cornelius,Lorena M. Amaral,Ashlyn C Harmon,Kedra Wallace,Alexia J. Thomas,Nathan Campbell,Jeremy Scott,Florian Herse,Nadine Haase,Janae Moseley,Gerd Wallukat,Ralf Dechend,Babbette LaMarca +12 more
TL;DR: This study demonstrates that NP TRegs can significantly improve inflammatory mediators, such as IL-17, TNF-α, and AT1-AA, which have been shown to increase blood pressure during pregnancy.
Journal ArticleDOI
CD74-Downregulation of Placental Macrophage-Trophoblastic Interactions in Preeclampsia.
Lukasz Przybyl,Nadine Haase,Michaela Golic,Julianna Rugor,Maria Emilia Solano,Petra C. Arck,Martin Gauster,Berthold Huppertz,Christoph Emontzpohl,Christian Stoppe,Jürgen Bernhagen,Lin Leng,Richard Bucala,Herbert Schulz,Arnd Heuser,M. Susanne Weedon-Fekjær,Guro M. Johnsen,Dirk Peetz,Friedrich C. Luft,Anne Cathrine Staff,Dominik N. Müller,Ralf Dechend,Florian Herse +22 more
TL;DR: It is hypothesized that cluster of differentiation 74 (CD74) downregulation on placental macrophages, leading to altered macrophage-trophoblast interaction, is involved in preeclampsia, which features hypertension, proteinuria, and placental anomalies.
Journal ArticleDOI
A Grhl2-dependent gene network controls trophoblast branching morphogenesis
Katharina Walentin,Christian Hinze,Max Werth,Nadine Haase,Saaket Varma,Robert J. Morell,Annekatrin Aue,Elisabeth Pötschke,David Warburton,Andong Qiu,Jonathan Barasch,Bettina Purfürst,Christoph Dieterich,Elena Popova,Michael Bader,Ralf Dechend,Anne Cathrine Staff,Zeliha Yesim Yurtdas,Ergin Kilic,Kai M. Schmidt-Ott +19 more
TL;DR: It is indicated that a conserved Grhl2-coordinated gene network controls trophoblast branching morphogenesis, thereby facilitating development of the site of feto-maternal exchange and might have implications for syndromes related to placental dysfunction.
Journal ArticleDOI
Disturbed Placental Imprinting in Preeclampsia Leads to Altered Expression of DLX5, a Human-Specific Early Trophoblast Marker
Julianna Zadora,Manvendra K. Singh,Florian Herse,Lukasz Przybyl,Nadine Haase,Michaela Golic,Hong Wa Yung,Berthold Huppertz,Judith E. Cartwright,Guy Whitley,Guro M. Johnsen,Giovanni Levi,Annette Isbruch,Herbert Schulz,Friedrich C. Luft,Dominik N. Müller,Anne Cathrine Staff,Laurence D. Hurst,Ralf Dechend,Zsuzsanna Izsvák +19 more
TL;DR: The analysis provides evidence of a true association among disturbed imprinting, gene expression, and preeclampsia, and identifies DLX5 as part of the human-specific regulatory network of trophoblast differentiation.