M
Max Werth
Researcher at Columbia University
Publications - 12
Citations - 1645
Max Werth is an academic researcher from Columbia University. The author has contributed to research in topics: Kidney & Cellular differentiation. The author has an hindex of 9, co-authored 12 publications receiving 1206 citations. Previous affiliations of Max Werth include Max Delbrück Center for Molecular Medicine.
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Journal ArticleDOI
Single-cell transcriptomics of the mouse kidney reveals potential cellular targets of kidney disease
Jihwan Park,Rojesh Shrestha,Chengxiang Qiu,Ayano Kondo,Shizheng Huang,Max Werth,Mingyao Li,Jonathan Barasch,Katalin Susztak +8 more
TL;DR: It is inferred that inherited kidney diseases that arise from distinct genetic mutations but share the same phenotypic manifestation originate from the same differentiated cell type, and that the collecting duct in kidneys of adult mice generates a spectrum of cell types through a newly identified transitional cell.
Journal ArticleDOI
The transcription factor grainyhead-like 2 regulates the molecular composition of the epithelial apical junctional complex
Max Werth,Katharina Walentin,Katharina Walentin,Annekatrin Aue,Annekatrin Aue,Jörg Schönheit,Anne Wuebken,Naomi Pode-Shakked,Larissa Vilianovitch,Bettina Erdmann,Benjamin Dekel,Michael Bader,Jonathan Barasch,Frank Rosenbauer,Friedrich C. Luft,Friedrich C. Luft,Kai M. Schmidt-Ott,Kai M. Schmidt-Ott +17 more
TL;DR: Evidence is provided that Grhl2 acts as a target gene-associated transcriptional activator of apical junctional complex components and, thereby, crucially participates in epithelial differentiation.
Journal ArticleDOI
The copy number variation landscape of congenital anomalies of the kidney and urinary tract
Miguel Verbitsky,Rik Westland,Alejandra Perez,Krzysztof Kiryluk,Qingxue Liu,Priya Krithivasan,Adele Mitrotti,David Fasel,Ekaterina Batourina,Matthew G. Sampson,Monica Bodria,Max Werth,Charlly Kao,Jeremiah Martino,Valentina P Capone,Asaf Vivante,Asaf Vivante,Shirlee Shril,Byum Hee Kil,Maddalena Marasa,Jun Zhang,Young Ji Na,Tze Y Lim,Dina Ahram,Patricia L. Weng,Erin L. Heinzen,Alba Carrea,Giorgio Piaggio,Loreto Gesualdo,Valeria Manca,Giuseppe Masnata,Maddalena Gigante,Daniele Cusi,Claudia Izzi,Francesco Scolari,Joanna A.E. van Wijk,Marijan Saraga,Domenico Santoro,Giovanni Conti,Pasquale Zamboli,Hope White,Dorota Drozdz,Katarzyna Zachwieja,Monika Miklaszewska,Marcin Tkaczyk,Daria Tomczyk,Anna Krakowska,Przemysław Sikora,Tomasz Jarmoliński,Maria K Borszewska-Kornacka,Robert Pawluch,Maria Szczepańska,Piotr Adamczyk,Małgorzata Mizerska-Wasiak,Grażyna Krzemień,Agnieszka Szmigielska,Marcin Zaniew,Mark G Dobson,John M Darlow,Prem Puri,David E. Barton,David E. Barton,Susan L. Furth,Bradley A. Warady,Zoran Gucev,Vladimir J Lozanovski,Vladimir J Lozanovski,Velibor Tasic,Isabella Pisani,Landino Allegri,Lida Rodas,Josep M. Campistol,Cécile Jeanpierre,Shumyle Alam,Pasquale Casale,Pasquale Casale,Craig S. Wong,Fangming Lin,Débora Marques de Miranda,Eduardo A. Oliveira,Ana Cristina Simões-e-Silva,Jonathan Barasch,Brynn Levy,Nan Wu,Nan Wu,Friedhelm Hildebrandt,Gian Marco Ghiggeri,Anna Latos-Bielenska,Anna Materna-Kiryluk,Feng Zhang,Hakon Hakonarson,Virginia E. Papaioannou,Cathy Mendelsohn,Ali G. Gharavi,Simone Sanna-Cherchi +94 more
TL;DR: Genome-wide analysis of copy number variants in 2,824 cases across the phenotypic spectrum of CAKUT sheds light on the genomic architecture of disease and identifies TBX6 as a driver forCAKUT subphenotypes in the 16p11.2 microdeletion syndrome.
Journal ArticleDOI
α–Intercalated cells defend the urinary system from bacterial infection
Neal Paragas,Ritwij Kulkarni,Max Werth,Kai M. Schmidt-Ott,Catherine S. Forster,Rong Deng,Qing-Yin Zhang,Eugenia Singer,Alexander D. Klose,Tian Huai Shen,Kevin P. Francis,Sunetra Ray,Soundarapandian Vijayakumar,Samuel Seward,Mary E. Bovino,Katherine Xu,Yared Takabe,Fábio E. Amaral,Sumit Mohan,Rebecca Wax,Kaitlyn A. Corbin,Simone Sanna-Cherchi,Kiyoshi Mori,Lynne L. Johnson,Thomas L. Nickolas,Vivette D. D'Agati,Chyuan-Sheng Lin,Andong Qiu,Qais Al-Awqati,Adam J. Ratner,Jonathan Barasch +30 more
TL;DR: Results indicate that A-ICs, which are known to regulate acid-base metabolism, are also critical for urinary defense against pathogenic bacteria.
Journal ArticleDOI
Genetic Drivers of Kidney Defects in the DiGeorge Syndrome.
Esther Lopez-Rivera,Yangfan P. Liu,Miguel Verbitsky,Blair R. Anderson,Valentina P Capone,Edgar A. Otto,Zhonghai Yan,Adele Mitrotti,Jeremiah Martino,Nicholas J Steers,David Fasel,Katarina Vukojević,Rong Deng,Silvia E. Racedo,Qingxue Liu,Max Werth,Rik Westland,Asaf Vivante,Gabriel Makar,Gabriel Makar,Monica Bodria,Matthew G. Sampson,Christopher E. Gillies,Virginia Vega-Warner,Mariarosa Maiorana,Donald Petrey,Barry Honig,Vladimir J Lozanovski,Rémi Salomon,Rémi Salomon,Laurence Heidet,Wassila Carpentier,Dominique Gaillard,Alba Carrea,Loreto Gesualdo,Daniele Cusi,Claudia Izzi,Francesco Scolari,Joanna A.E. van Wijk,Adela Arapović,Mirna Saraga-Babić,Marijan Saraga,Nenad Kunac,Ali Samii,Donna M. McDonald-McGinn,Terrence B. Crowley,Elaine H. Zackai,Dorota Drozdz,Monika Miklaszewska,Marcin Tkaczyk,Przemysław Sikora,Maria Szczepańska,Małgorzata Mizerska-Wasiak,Grażyna Krzemień,Agnieszka Szmigielska,Marcin Zaniew,John M Darlow,Prem Puri,David E. Barton,David E. Barton,Emilio Casolari,Susan L. Furth,Bradley A. Warady,Zoran Gucev,Hakon Hakonarson,Hana Flögelová,Velibor Tasic,Anna Latos-Bielenska,Anna Materna-Kiryluk,Landino Allegri,Craig S. Wong,Iain A. Drummond,V. D’Agati,Akira Imamoto,Jonathan Barasch,Friedhelm Hildebrandt,Krzysztof Kiryluk,Richard P. Lifton,Bernice E. Morrow,Cécile Jeanpierre,Virginia E. Papaioannou,Gian Marco Ghiggeri,Ali G. Gharavi,Nicholas Katsanis,Simone Sanna-Cherchi +84 more
TL;DR: A recurrent 370‐kb deletion at the 22q11.2 locus is identified as a driver of kidney defects in the DiGeorge syndrome and in sporadic congenital kidney and urinary tract anomalies.