N
Nan Qin
Researcher at Dresden University of Technology
Publications - 21
Citations - 1021
Nan Qin is an academic researcher from Dresden University of Technology. The author has contributed to research in topics: Progenitor cell & Catecholamine. The author has an hindex of 13, co-authored 21 publications receiving 856 citations. Previous affiliations of Nan Qin include Beijing Genomics Institute.
Papers
More filters
Journal ArticleDOI
MAX Mutations Cause Hereditary and Sporadic Pheochromocytoma and Paraganglioma
Nelly Burnichon,Alberto Cascón,Francesca Schiavi,Nicole Paes Morales,Iñaki Comino-Méndez,N. Abermil,Lucía Inglada-Pérez,Aguirre A. de Cubas,Laurence Amar,Marta Barontini,Sandra Bernaldo de Quirós,Jérôme Bertherat,Yves-Jean Bignon,Marinus J. Blok,Sara Bobisse,Salud Borrego,Maurizio Castellano,Philippe Chanson,María-Dolores Chiara,Eleonora P M Corssmit,M. Giacchè,Ronald R. de Krijger,Tonino Ercolino,Xavier Girerd,Encarna B. Gomez-Garcia,Álvaro Gómez-Graña,Isabelle Guilhem,Frederik J. Hes,Emiliano Honrado,Esther Korpershoek,Jacques W.M. Lenders,Rocío Letón,Arjen R. Mensenkamp,Anna Merlo,Luigi Mori,Arnaud Murat,Peggy Pierre,Pierre-François Plouin,Tamara Prodanov,Miguel Quesada-Charneco,Nan Qin,Elena Rapizzi,Victoria M. Raymond,Nicole Reisch,Giovanna Roncador,Macarena Ruiz-Ferrer,F Schillo,Alexander P.A. Stegmann,Carlos Suárez,Elisa Taschin,Henri J L M Timmers,Carli M. J. Tops,Miguel Urioste,Felix Beuschlein,Karel Pacak,Massimo Mannelli,Patricia L. M. Dahia,Giuseppe Opocher,Graeme Eisenhofer,Anne-Paule Gimenez-Roqueplo,Mercedes Robledo +60 more
TL;DR: Germline mutations in MAX are responsible for 1.12% of PCC/PGL in patients without evidence of other known mutations and should be considered in the genetic work-up of these patients.
Journal ArticleDOI
Catecholamine metabolomic and secretory phenotypes in phaeochromocytoma
Graeme Eisenhofer,Karel Pacak,Thanh-Truc Huynh,Nan Qin,Gennady Bratslavsky,W. Marston Linehan,Massimo Mannelli,Peter Friberg,Stefan K.G. Grebe,Henri J L M Timmers,Stefan R. Bornstein,Jacques W.M. Lenders +11 more
TL;DR: The utility of comprehensive catecholamine metabolite profiling for characterising the distinct and highly diverse catechlamine metabolomic and secretory phenotypes among different groups of patients with PPGLs is established.
Journal ArticleDOI
Krebs cycle metabolite profiling for identification and stratification of pheochromocytomas/paragangliomas due to succinate dehydrogenase deficiency.
Susan Richter,Mirko Peitzsch,Elena Rapizzi,Jacques W. M. Lenders,Nan Qin,Aguirre A. de Cubas,Francesca Schiavi,Jyotsna U. Rao,Felix Beuschlein,Marcus Quinkler,Henri J L M Timmers,Giuseppe Opocher,Massimo Mannelli,Karel Pacak,Mercedes Robledo,Graeme Eisenhofer +15 more
TL;DR: Mass spectrometric-based measurements of ratios of succinate:fumarate and other metabolites in PPGLs offer a useful method to identify patients for testing of SDHx mutations, with additional utility to quantitatively assess functionality of mutations and metabolic factors responsible for malignant risk.
Journal ArticleDOI
Reference intervals for plasma free metanephrines with an age adjustment for normetanephrine for optimized laboratory testing of phaeochromocytoma
Graeme Eisenhofer,Peter Lattke,Maria Herberg,Gabriele Siegert,Nan Qin,Roland Därr,Jana Hoyer,Arno Villringer,Aleksander Prejbisz,Andrzej Januszewicz,Alan T. Remaley,Victoria Martucci,Karel Pacak,H. Alec Ross,Fred C.G.J. Sweep,Jacques W.M. Lenders +15 more
TL;DR: Age-adjusted cut-off of reference intervals for plasma normetanephrine and optimized cut-offs for metanephine useful for minimizing false-positive results are established.
Journal ArticleDOI
Opposing effects of HIF1α and HIF2α on chromaffin cell phenotypic features and tumor cell proliferation: Insights from MYC‐associated factor X
Nan Qin,Aguirre A. de Cubas,Ruben Garcia-Martin,Susan Richter,Mirko Peitzsch,Mario Menschikowski,Jacques W.M. Lenders,Jacques W.M. Lenders,Henri J L M Timmers,Massimo Mannelli,Giuseppe Opocher,Matina Economopoulou,Gabriele Siegert,Triantafyllos Chavakis,Karel Pacak,Mercedes Robledo,Graeme Eisenhofer +16 more
TL;DR: Overexpression of HIF2α in chromaffin cell tumors due to mutations affecting HIF stabilization explains their proliferative features and why the tumors fail to differentiate even when exposed locally to adrenal steroids.