E
Engin Özkan
Researcher at University of Chicago
Publications - 50
Citations - 3498
Engin Özkan is an academic researcher from University of Chicago. The author has contributed to research in topics: Biology & Immunoglobulin superfamily. The author has an hindex of 22, co-authored 30 publications receiving 2971 citations. Previous affiliations of Engin Özkan include University of Texas Southwestern Medical Center & Stanford University.
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Journal ArticleDOI
Gabapentin Receptor α2δ-1 Is a Neuronal Thrombospondin Receptor Responsible for Excitatory CNS Synaptogenesis
Cagla Eroglu,Cagla Eroglu,Nicola J. Allen,Michael W. Susman,Nancy A. O'Rourke,Chan Young Park,Engin Özkan,Chandrani Chakraborty,Sara B. Mulinyawe,Douglas S. Annis,Andrew D. Huberman,Eric M. Green,Jack Lawler,Ricardo E. Dolmetsch,K. Christopher Garcia,Stephen J. Smith,Z. David Luo,Arnon Rosenthal,Deane F. Mosher,Ben A. Barres +19 more
TL;DR: The neuronal thrombospondin receptor involved in CNS synapse formation is identified as alpha2delta-1, the receptor for the anti-epileptic and analgesic drug gabapentin and suggested that gapapentin may function therapeutically by blocking new synapses formation.
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Deconstructing the Peptide-MHC Specificity of T Cell Recognition
Michael E. Birnbaum,Juan L. Mendoza,Sethi Dhruv Kam,Shen Dong,Jacob Glanville,Jessica Dobbins,Engin Özkan,Mark M. Davis,Kai W. Wucherpfennig,K. Christopher Garcia +9 more
TL;DR: The mechanistic basis of TCR cross-reactivity described here enables effective surveillance of diverse self and foreign antigens without necessitating degenerate recognition of nonhomologous peptides.
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Engineered SIRPα Variants as Immunotherapeutic Adjuvants to Anticancer Antibodies
Kipp Weiskopf,Aaron M. Ring,Chia Chi Ho,Jens-Peter Volkmer,Aron M. Levin,Anne Kathrin Volkmer,Engin Özkan,Nathaniel B. Fernhoff,Matt van de Rijn,Irving L. Weissman,K. Christopher Garcia +10 more
TL;DR: This work modified the binding domain of human SIRPα, the receptor for CD47, for use as a CD47 antagonist, providing a universal method for augmenting the efficacy of therapeutic anticancer antibodies.
Journal ArticleDOI
Mechanistic insight into the allosteric activation of a ubiquitin-conjugating enzyme by RING-type ubiquitin ligases.
TL;DR: It is shown that, although the E3-binding site on the human E2 UbcH5b is distant from its active site, two RING-type minimal E3 modules lacking substrate-binding functions greatly stimulate the rate of ubiquitin release from the Ubch5b-ubiquitin thioester.
Journal ArticleDOI
An Extracellular Interactome of Immunoglobulin and LRR Proteins Reveals Receptor-Ligand Networks
Engin Özkan,Robert A. Carrillo,Catharine L. Eastman,Richard Weiszmann,Deepa Waghray,Karl G. Johnson,Kai Zinn,Susan E. Celniker,K. Christopher Garcia +8 more
TL;DR: In this paper, a set of 202 proteins composed of the Drosophila melanogaster immunoglobulin superfamily (IgSF), fibronectin type III (FnIII), and leucine-rich repeat (LRR) families were probed for extracellular interactions.