D
Douglas S. Annis
Researcher at University of Wisconsin-Madison
Publications - 72
Citations - 4257
Douglas S. Annis is an academic researcher from University of Wisconsin-Madison. The author has contributed to research in topics: Integrin & Thrombospondin. The author has an hindex of 31, co-authored 69 publications receiving 3871 citations. Previous affiliations of Douglas S. Annis include Children's Hospital of Orange County & Scripps Research Institute.
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Journal ArticleDOI
Gabapentin Receptor α2δ-1 Is a Neuronal Thrombospondin Receptor Responsible for Excitatory CNS Synaptogenesis
Cagla Eroglu,Cagla Eroglu,Nicola J. Allen,Michael W. Susman,Nancy A. O'Rourke,Chan Young Park,Engin Özkan,Chandrani Chakraborty,Sara B. Mulinyawe,Douglas S. Annis,Andrew D. Huberman,Eric M. Green,Jack Lawler,Ricardo E. Dolmetsch,K. Christopher Garcia,Stephen J. Smith,Z. David Luo,Arnon Rosenthal,Deane F. Mosher,Ben A. Barres +19 more
TL;DR: The neuronal thrombospondin receptor involved in CNS synapse formation is identified as alpha2delta-1, the receptor for the anti-epileptic and analgesic drug gabapentin and suggested that gapapentin may function therapeutically by blocking new synapses formation.
Gabapentin Receptor alpha 2 delta-1 Is a Neuronal Thrombospondin Receptor Responsible for Excitatory CNS Synaptogenesis
Cagla Eroglu,Nicola J. Allen,Michael W. Susman,Nancy A. O'Rourke,Chan Young Park,Engin Oezkan,Chandrani Chakraborty,Sara B. Mulinyawe,Douglas S. Annis,Andrew D. Huberman,Eric M. Green,Jack Lawler,Ricardo E. Dolmetsch,K. Christopher Garcia,Stephen J. Smith,Z. David Luo,Arnon Rosenthal,Deane F. Mosher,Ben A. Barres +18 more
Journal ArticleDOI
Hereditary variation in platelet integrin α2β1 density is associated with two silent polymorphisms in the α2 gene coding sequence
Thomas J. Kunicki,Marcie Kritzik,Marcie Kritzik,Douglas S. Annis,Douglas S. Annis,Diane J. Nugent,Diane J. Nugent +6 more
TL;DR: These findings prove that the level of platelet α2β1 is an inherited trait, and establish that these silent alleles within the coding sequence of the α2 gene are linked to the genetic basis for variation in receptor density.
Journal ArticleDOI
Fibrillin Assembly Requires Fibronectin
Laetitia Sabatier,Daliang Chen,Christine Fagotto-Kaufmann,Dirk Hubmacher,Marc D. McKee,Douglas S. Annis,Deane F. Mosher,Dieter P. Reinhardt +7 more
TL;DR: Human dermal fibroblasts are used to analyze the assembly of fibrillin-1 in dependence of other matrix-forming proteins and mapping studies revealed that the major binding interaction between fibrillins and fibronectin involves the collagen/gelatin-binding region between domains FNI(6) and F NI(9).
Journal ArticleDOI
ADAMTS1 mediates the release of antiangiogenic polypeptides from TSP1 and 2.
Nathan V. Lee,Makoto Sato,Douglas S. Annis,Joseph A. Loo,Lily Wu,Deane F. Mosher,M. Luisa Iruela-Arispe +6 more
TL;DR: The findings have unraveled a mechanistic explanation for the angiostatic functions attributed to ADAMTS1 and demonstrated in vivo processing of TSP1 under situations of tissue repair.