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Nanda R. Rodrigues
Researcher at University of Oxford
Publications - 18
Citations - 1392
Nanda R. Rodrigues is an academic researcher from University of Oxford. The author has contributed to research in topics: Spinal muscular atrophy & Gene. The author has an hindex of 15, co-authored 18 publications receiving 1365 citations.
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Journal ArticleDOI
The Dual Specificity Phosphatases M3/6 and MKP-3 Are Highly Selective for Inactivation of Distinct Mitogen-activated Protein Kinases
Marco Muda,Aspasia Theodosiou,Nanda R. Rodrigues,Ursula Boschert,Montserrat Camps,Corine Gillieron,Kay E. Davies,Alan Ashworth,Steve Arkinstall +8 more
TL;DR: Two new dual specificity phosphatases of the CL100/MKP-1 family that are selective for inactivating ERK or JNK/SAPK and p38 MAP kinases when expressed in COS-7 cells are described.
Journal ArticleDOI
Missense mutation clustering in the survival motor neuron gene: a role for a conserved tyrosine and glycine rich region of the protein in RNA metabolism?
Kevin Talbot,Chris P. Ponting,A M Theodosiou,Nanda R. Rodrigues,Robert Surtees,Roger Mountford,Kay E. Davies +6 more
TL;DR: A novel missense mutation is described and the subsequent identification of a triplicated tyrosine-glycine (Y-G) peptide sequence at the C-terminal of SMN which encompasses each of the three predicted amino acid sequence substitutions.
Journal ArticleDOI
The Mitogen-activated Protein Kinase Phosphatase-3 N-terminal Noncatalytic Region Is Responsible for Tight Substrate Binding and Enzymatic Specificity
Marco Muda,Aspasia Theodosiou,Corine Gillieron,Anna Smith,Christian Chabert,Montserrat Camps,Ursula Boschert,Nanda R. Rodrigues,Kay E. Davies,Alan Ashworth,Steve Arkinstall +10 more
TL;DR: It is shown that MKP-3 enzymatic specificity is paralleled by tight binding to both ERK1 and ERK2 while, in contrast, little or no interaction with either c-Jun N-terminal kinase/stress activated protein kinase (JNK/SAPK) or p38 MAP kinases was detected.
Journal ArticleDOI
Crosses of Nod Mice with the Related Non Strain - a Polygenic Model for Iddm
M A McAleer,Peter C. Reifsnyder,Sheila M Palmer,Michal Prochazka,Jennifer M. Love,James B. Copeman,Elizabeth E. Powell,Nanda R. Rodrigues,Jan-Bas Prins,David V. Serreze,Nicole H. DeLarato,Linda S. Wicker,Laurence B. Peterson,Nicholas J. Schork,John A. Todd,Edward H. Leiter +15 more
TL;DR: This study shows that the diabetogenic phenotype can be achieved through the actions of variable combinations of MHC-unlinked genes and a diabetogenesis MHC haplotype through outcrossing NOD mice to other inbred strains congenic for the NOD M HC haplotype.
Journal ArticleDOI
Syntenic Organization of the Mouse Distal Chromosome 7 Imprinting Cluster and the Beckwith-Wiedemann Syndrome Region in Chromosome 11p15.5
Martina Paulsen,Karen Davies,Lucy Bowden,Angela J. Villar,Angela J. Villar,Olivia Franck,Martina Fuermann,Wendy Dean,Tom Moore,Nanda R. Rodrigues,Kay E. Davies,Ren J. Hu,Andrew P. Feinberg,Eamonn R. Maher,Wolf Reik,Jörn Walter +15 more
TL;DR: This study establishes a complete contig of clones along the murine imprinting cluster on distal chromosome 7 syntenic with the human imprinting region at 11p15.5 associated with Beckwith-Wiedemann syndrome and opens the way for a systematic analysis of the cluster by genetic manipulation in the mouse.