W
Wanling Yang
Researcher at University of Hong Kong
Publications - 137
Citations - 6128
Wanling Yang is an academic researcher from University of Hong Kong. The author has contributed to research in topics: Genome-wide association study & Gene. The author has an hindex of 34, co-authored 120 publications receiving 4963 citations. Previous affiliations of Wanling Yang include Pamela Youde Nethersole Eastern Hospital & Shandong University.
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Journal ArticleDOI
Genome-wide association study in Asian populations identifies variants in ETS1 and WDFY4 associated with systemic lupus erythematosus.
Wanling Yang,Nan Shen,Dong-Qing Ye,Qiji Liu,Qiji Liu,Yan Zhang,Xiaoxia Qian,Nattiya Hirankarn,Dingge Ying,Hai-Feng Pan,Chi Chiu Mok,Tak Mao Chan,Raymond Woon Sing Wong,KW Lee,Mo Yin Mok,Sik Nin Wong,Alexander Moon Ho Leung,Xiang-Pei Li,Yingyos Avihingsanon,Chun-Ming Wong,Tsz Leung Lee,Marco Ho,Pamela Pui Wah Lee,Yuk Kwan Chang,Philip H. Li,Ruo-Jie Li,Ruo-Jie Li,Lu Zhang,Wilfred Hing Sang Wong,Irene Oi-Lin Ng,Chak Sing Lau,Pak C. Sham,Yu-Lung Lau +32 more
TL;DR: This study confirmed association of the HLA locus, STAT4, TNFSF4, BLK, BANK1, IRF5, and TNFAIP3 with SLE in Asians and found new genetic findings that may help gain a better understanding of the disease and the functions of the genes involved.
Journal ArticleDOI
μ opioid receptor knockout in mice: Effects on ligand-induced analgesia and morphine lethality
TL;DR: In these MOR-knockout mice, the analgesic effects of morphine, its major metabolites, morphine-6-glucuronide, and morphine- 6-ethereal sulfate, as well as morphine-induced lethality, were drastically reduced, whereas the effects of DPDPE and U50488 remained unchanged.
Journal ArticleDOI
Genome-wide mega-analysis identifies 16 loci and highlights diverse biological mechanisms in the common epilepsies
Bassel Abou-Khalil,Pauls Auce,Andreja Avbersek,Melanie Bahlo,David J. Balding,Thomas Bast,Larry Baum,Albert J. Becker,Felicitas Becker,Bianca Berghuis,Samuel F. Berkovic,Katja E. Boysen,Jonathan P. Bradfield,Lawrence C. Brody,Russell J. Buono,Ellen Campbell,Gregory D. Cascino,Claudia B. Catarino,Gianpiero L. Cavalleri,Stacey S. Cherny,Krishna Chinthapalli,Alison J. Coffey,Alastair Compston,Antonietta Coppola,Patrick Cossette,John Craig,Gerrit-Jan de Haan,Peter De Jonghe,Carolien G.F. de Kovel,Norman Delanty,Chantal Depondt,Orrin Devinsky,Dennis J. Dlugos,Colin P. Doherty,Christian E. Elger,Johan G. Eriksson,Thomas N. Ferraro,Martha Feucht,Ben Francis,Andre Franke,Jacqueline A. French,Saskia Freytag,Verena Gaus,Eric B. Geller,Christian Gieger,Tracy A. Glauser,Simon Glynn,David Goldstein,Hongsheng Gui,Youling Guo,Kevin Haas,Hakon Hakonarson,Kerstin Hallmann,Sheryl R. Haut,Erin L. Heinzen,Ingo Helbig,Christian Hengsbach,Helle Hjalgrim,Michele Iacomino,Andres Ingason,Jennifer Jamnadas-Khoda,Marvin Johnson,Reetta Kälviäinen,Anne-Mari Kantanen,Dalia Kasperaviciute,Dorothée G.A. Kasteleijn-Nolst Trenité,Heidi E. Kirsch,Robert C. Knowlton,Bobby P. C. Koeleman,Roland Krause,Martin Krenn,Wolfram S. Kunz,Ruben Kuzniecky,Patrick Kwan,Dennis Lal,Yu-Lung Lau,Anna-Elina Lehesjoki,Holger Lerche,Costin Leu,Wolfgang Lieb,Dick Lindhout,Warren D. Lo,Iscia Lopes-Cendes,Daniel H. Lowenstein,Alberto Malovini,Anthony G Marson,Thomas U. Mayer,Mark McCormack,James L. Mills,Nasir Mirza,Martina Moerzinger,Rikke S. Møller,Anne M. Molloy,Hiltrud Muhle,Mark R Newton,Ping-Wing Ng,Markus M. Noethen,Peter Nuernberg,Terence J. O'Brien,Karen Oliver,Aarno Palotie,Faith Pangilinan,Sarah Peter,Slavé Petrovski,Annapurna Poduri,Michael Privitera,Rodney A. Radtke,Sarah Rau,Philipp S. Reif,Eva M. Reinthaler,Felix Rosenow,Josemir W. Sander,Thomas Sander,Theresa Scattergood,Steven C. Schachter,Christoph J. Schankin,Ingrid E. Scheffer,Bettina Schmitz,Susanne Schoch,Pak C. Sham,Jerry J. Shih,Graeme J. Sills,Sanjay M. Sisodiya,Lisa Slattery,Alexander R. H. Smith,David F. Smith,Mike Smith,Philip E. M. Smith,Anja C M Sonsma,Doug Speed,Michael R. Sperling,Bernhard J. Steinhoff,Ulrich Stephani,Remi Stevelink,Konstantin Strauch,Pasquale Striano,H. Stroink,Rainer Surges,K. Meng Tan,Liu Lin Thio,G. Neil Thomas,Marian Todaro,Rossana Tozzi,Maria Stella Vari,Eileen P.G. Vining,Frank Visscher,Sarah von Spiczak,Nicole M. Walley,Yvonne G. Weber,Zhi Wei,Judith L.Z. Weisenberg,Christopher D. Whelan,Peter Widdess-Walsh,Markus Wolff,Stefan Wolking,Wanling Yang,Federico Zara,Fritz Zimprich,Int League Against Epilepsy Conso +158 more
TL;DR: The authors perform genome-wide association studies for 3 broad and 7 subtypes of epilepsy and identify 16 loci - 11 novel - that are further annotated by eQTL and partitioned heritability analyses that provide leads for epilepsy therapies based on underlying pathophysiology.
Journal ArticleDOI
Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease.
Chiea Chuen Khor,Chiea Chuen Khor,Sonia Davila,Sonia Davila,Willemijn B. Breunis,Yi-Ching Lee,Chisato Shimizu,Chisato Shimizu,Victoria J. Wright,Rae S. M. Yeung,Dennis E.K. Tan,Kar Seng Sim,Jie Jin Wang,Jie Jin Wang,Tien Yin Wong,Tien Yin Wong,Tien Yin Wong,Junxiong Pang,Junxiong Pang,Paul Mitchell,Rolando Cimaz,Nagib Dahdah,Yiu-fai Cheung,Guo Ying Huang,Wanling Yang,In Sook Park,Jong-Keuk Lee,Jer-Yuarn Wu,Michael Levin,Jane C. Burns,Jane C. Burns,David Burgner,David Burgner,Taco W. Kuijpers,Martin L. Hibberd,Martin L. Hibberd,Yu-Lung Lau,Jing Zhang,Xiao Jing Ma,Fang Liu,Lin Wu,Jeong Jin Yoo,Soo-Jong Hong,Kwi Joo Kim,Jae-Jung Kim,Young-Mi Park,Young Mi Hong,Sejung Sohn,Gi Young Jang,Kee Soo Ha,Hyo Kyoung Nam,Jung Hye Byeon,Sin Weon Yun,Myung Ki Han,Kyung-Yil Lee,Ja Young Hwang,Jung Woo Rhim,Min Seob Song,Hyoung Doo Lee,Dong Soo Kim,Jae Moo Lee,Jeng Sheng Chang,Fuu Jen Tsai,Chi Di Liang,Ming-Ren Chen,Hsin Chi,Nan Chang Chiu,Fu Yuan Huang,Luan-Yin Chang,Li-Min Huang,Ho-Chang Kuo,Kao Pin Huang,Meng Luen Lee,Betau Hwang,Yhu Chering Huang,Pi Chang Lee,Miranda Odam,Miranda Odam,Frank T. Christiansen,Campbell S. Witt,Paul N. Goldwater,Paul N. Goldwater,Nigel Curtis,Nigel Curtis,Pamela Palasanthiran,John B. Ziegler,Michael D. Nissen,Clare Nourse,Irene M. Kuipers,J Ottenkamp,Judy Geissler,Maarten H Biezeveld,Carline E. Tacke,Luc Filippini,Paul A. Brogan,Nigel Klein,Vanita Shah,M J Dillon,Robert Booy,Delane Shingadia,Anu Bose,Thomas Mukasa,Robert Tulloh,Colin Michie,Jane W. Newburger,Annette L. Baker,Anne H. Rowley,Stanford T. Shulman,Wilbert H. Mason,Masato Takahashi,Marian E. Melish,Adriana H. Tremoulet,Ananth C. Viswanathan,Elena Rochtchina,John Attia,Rodney J. Scott,Elizabeth G. Holliday,Stephen B. Harrap +117 more
TL;DR: The involvement of the FCGR2A locus may have implications for understanding immune activation in Kawasaki disease pathogenesis and the mechanism of response to intravenous immunoglobulin, the only proven therapy for this disease.
Journal ArticleDOI
A Functional Variant in MicroRNA-146a Promoter Modulates Its Expression and Confers Disease Risk for Systemic Lupus Erythematosus
Xiaobing Luo,Wanling Yang,Dong-Qing Ye,Huijuan Cui,Yan-Yan Zhang,Nattiya Hirankarn,Xiaoxia Qian,Yuanjia Tang,Yu-Lung Lau,Niek de Vries,Paul P. Tak,Betty P. Tsao,Nan Shen +12 more
TL;DR: The data identified and confirmed an association between a functional promoter variant of miR-146a and SLE, and identified a novel genetic variant in the promoter region exhibiting evidence for association with SLE that was replicated independently in 7,182 Asians.