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Shunle Chen
Researcher at Shanghai Jiao Tong University
Publications - 63
Citations - 4941
Shunle Chen is an academic researcher from Shanghai Jiao Tong University. The author has contributed to research in topics: Lupus erythematosus & Systemic lupus erythematosus. The author has an hindex of 27, co-authored 61 publications receiving 4524 citations. Previous affiliations of Shunle Chen include Renji Hospital & Chinese Academy of Sciences.
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Journal ArticleDOI
Modulatory Effects of 1,25-Dihydroxyvitamin D3 on Human B Cell Differentiation
TL;DR: It is found that 1,25(OH)2D3 may play an important role in the maintenance of B cell homeostasis and that the correction of vitamin D deficiency may be useful in the treatment of B Cell-mediated autoimmune disorders.
Journal Article
[Expression of fusion proteins in beta(2)GP I gene-transfected HEp-2 cells and its clinical application].
Liangjing Lu,Shunle Chen,Yue-ying Gu,Nan Shen,Chunde Bao,Yuan Wang,Chengde Yang,Ping Ye,Chong-zhao Yu +8 more
TL;DR: As a new kind of substrate of IIF, beta( 2)GP I transfectant can be used to detect anti-beta(2)GP-I antibodies and keep the immunofluorescent property of HEp-2 cells in IFANA test and can be use as substrate for routine IFANA detection.
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MicroRNA-146A contributes to abnormal activation of the type I interferon pathway in human lupus by targeting the key signaling proteins.
Yuanjia Tang,Xiaobing Luo,Huijuan Cui,Xuming Ni,Min Yuan,Yanzhi Guo,Xinfang Huang,Haibo Zhou,Niek de Vries,Paul P. Tak,Shunle Chen,Nan Shen +11 more
TL;DR: Investigation of the contribution of microRNA-146a, identified in the pilot expression profiling step, to the pathogenesis of systemic lupus erythematosus revealed a negative regulator of innate immunity, which provides potential novel strategies for therapeutic intervention.
Journal ArticleDOI
miR-155 and Its Star-Form Partner miR-155* Cooperatively Regulate Type I Interferon Production by Human Plasmacytoid Dendritic Cells
TL;DR: This study identified and validated novel miRNA-protein networks involved in regulating human plasmacytoid dendritic cell (PDC) activation, and demonstrated that miR-155* and mi-155 were inversely regulated by autocrine/paracrine type I interferon and TLR7-activated KHSRP at the posttranscriptional level.
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Sex-specific association of X-linked Toll-like receptor 7 (TLR7) with male systemic lupus erythematosus
Nan Shen,Qiong Fu,Qiong Fu,Yun Deng,Yun Deng,Xiaoxia Qian,Zhao Jian,Kenneth M. Kaufman,Yee Ling Wu,C. Yung Yu,Yuanjia Tang,Ji Yih Chen,Wanling Yang,Maida Wong,Aya Kawasaki,Naoyuki Tsuchiya,Takayuki Sumida,Yasushi Kawaguchi,Hwee Siew Howe,Mo Yin Mok,So Young Bang,Fei Lan Liu,Deh Ming Chang,Yoshinari Takasaki,Hiroshi Hashimoto,John B. Harley,Joel M. Guthridge,Jennifer M. Grossman,Rita M. Cantor,Yeong Wook Song,Sang Cheol Bae,Shunle Chen,Bevra H. Hahn,Yu-Lung Lau,Betty P. Tsao +34 more
TL;DR: A functional polymorphism in type I IFN pathway gene TLR7 predisposing to SLE is established, especially in Chinese and Japanese male subjects, with a stronger effect in male than female subjects.