N
Narayanaswamy Ramesh
Researcher at Boston Children's Hospital
Publications - 11
Citations - 1321
Narayanaswamy Ramesh is an academic researcher from Boston Children's Hospital. The author has contributed to research in topics: T cell & Mutation. The author has an hindex of 9, co-authored 11 publications receiving 1232 citations. Previous affiliations of Narayanaswamy Ramesh include Tohoku University.
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Journal ArticleDOI
Defective expression of the CD40 ligand in X chromosome-linked immunoglobulin deficiency with normal or elevated IgM.
Ramsay Fuleihan,Narayanaswamy Ramesh,R Loh,Haifa H. Jabara,R S Rosen,Talal A. Chatila,Shu Man Fu,I Stamenkovic,Raif S. Geha +8 more
TL;DR: In this paper, CD40 mAb plus interleukin 4 induced the patients' B cells to synthesize IgE and to undergo deletional switch recombination, which suggests that defective expression of the CD40 ligand underlies the failure of isotype switching in this disease.
Journal ArticleDOI
Erk/Src Phosphorylation of Cortactin Acts as a Switch On-Switch Off Mechanism That Controls Its Ability To Activate N-WASP
Narcisa Martinez-Quiles,Hsin-Yi Henry Ho,Marc W. Kirschner,Narayanaswamy Ramesh,Raif S. Geha +4 more
TL;DR: It is proposed that Erk phosphorylation liberates the SH3 domain of cortactin from intramolecular interactions with proline-rich regions, causing it to synergize with WASP and N-WASP in activating the Arp2/3 complex, and that Src phosphorylated terminates cortact in activation of N-wASP and WASP.
Journal ArticleDOI
Wiskott-Aldrich syndrome: a comprehensive review.
TL;DR: The absence of functional WASp leads to a severe clinical phenotype that can result in death if not diagnosed and treated early in life, and the treatment of choice with the best outcome is hematopoietic stem cell transplantation.
Journal ArticleDOI
CD40lbase: a database of CD40L gene mutations causing X-linked hyper-IgM syndrome.
Luigi D. Notarangelo,Manuel C. Peitsch,Tore G. Abrahamsen,Colette Bachelot,Pierre Bordigoni,Andrew J. Cant,Helen Chapel,Mauritio Clementi,Sarah Deacock,Geneviève de Saint Basile,Marzia Duse,Teresa Espanol,Amos Etzioni,Anders Fasth,Alain Fischer,Silvia Giliani,Lina Gomez,Lennart Hammarström,Alison L Jones,Maria Kanariou,Christine Kinnon,Timo Klemola,Richard A. Kroczek,Jacov Levy,Núria Matamoros,V. Monafo,Paolo Paolucci,Igor Reznick,Ozden Sanal,C. I. Edvard Smith,Robin Thompson,Pier-Angelo Tovo,Anna Villa,Mauno Vihinen,Jaak M. Vossen,Ben J.M. Zegers,Hans D. Ochs,Mary Ellen Conley,M. Iseki,Narayanaswamy Ramesh,Mitsunobu Shimadzu,Osamu Saiki +41 more
TL;DR: A database (CD40Lbase) of CD40L mutations has now been established, and the resultant information, together with other mutations reported elsewhere in the literature, is presented here.
Journal Article
Induction of human T cell proliferation by a monoclonal antibody to CD5.
TL;DR: It is indicated that CD5 should be added to the list of surface molecules that can signal T cells to proliferate.