N
Natalie E. Farrawell
Researcher at University of Wollongong
Publications - 22
Citations - 598
Natalie E. Farrawell is an academic researcher from University of Wollongong. The author has contributed to research in topics: Ubiquitin & Proteostasis. The author has an hindex of 10, co-authored 18 publications receiving 408 citations. Previous affiliations of Natalie E. Farrawell include Illawarra Health & Medical Research Institute.
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Journal ArticleDOI
CCNF mutations in amyotrophic lateral sclerosis and frontotemporal dementia
Kelly L. Williams,Kelly L. Williams,Simon Topp,Shu Yang,Bradley N. Smith,Jennifer A. Fifita,Sadaf T. Warraich,Katharine Y. Zhang,Natalie E. Farrawell,Caroline Vance,Xun Hu,Alessandra Chesi,Claire S. Leblond,Claire S. Leblond,Albert Lee,Stephanie L. Rayner,Vinod Sundaramoorthy,Vinod Sundaramoorthy,Carol Dobson-Stone,Carol Dobson-Stone,Mark P. Molloy,Marka van Blitterswijk,Dennis W. Dickson,Ronald C. Petersen,Neill R. Graff-Radford,Bradley F. Boeve,Melissa E. Murray,Cyril Pottier,Emily K. Don,Claire Winnick,Emily P. McCann,Alison L. Hogan,Hussein Daoud,Hussein Daoud,Annie Levert,Annie Levert,Patrick A. Dion,Patrick A. Dion,Jun Mitsui,Hiroyuki Ishiura,Yuji Takahashi,Jun Goto,Jason E. Kost,Jason E. Kost,Cinzia Gellera,Athina Soragia Gkazi,Jack W. Miller,Joanne D. Stockton,William S. Brooks,Karyn Boundy,Meraida Polak,José Luis Muñoz-Blanco,Jesús Esteban-Pérez,Alberto Rábano,Orla Hardiman,Karen E. Morrison,Karen E. Morrison,Karen E. Morrison,Nicola Ticozzi,Vincenzo Silani,Jacqueline de Belleroche,Jonathan D. Glass,John B.J. Kwok,John B.J. Kwok,Gilles J. Guillemin,Roger S. Chung,Shoji Tsuji,Robert H. Brown,Alberto García-Redondo,Rosa Rademakers,John Landers,Aaron D. Gitler,Guy A. Rouleau,Guy A. Rouleau,Nicholas J. Cole,Nicholas J. Cole,Justin J. Yerbury,Julie D. Atkin,Julie D. Atkin,Christopher Shaw,Garth A. Nicholson,Ian P. Blair +81 more
TL;DR: In this article, the authors used genome-wide linkage analysis in a large ALS/FTD kindred to identify a novel disease locus on chromosome 16p13.3, which encodes cyclin F, a component of an E3 ubiquitin-protein ligase complex (SCFCyclin F).
Journal ArticleDOI
Distinct partitioning of ALS associated TDP-43, FUS and SOD1 mutants into cellular inclusions
Natalie E. Farrawell,Natalie E. Farrawell,Isabella A. Lambert-Smith,Isabella A. Lambert-Smith,Sadaf T. Warraich,Ian P. Blair,Darren N. Saunders,Darren N. Saunders,Danny M. Hatters,Justin J. Yerbury,Justin J. Yerbury +10 more
TL;DR: It is concluded that the RNA binding proteins TDP-43 and FUS do not consistently fit the currently characterised inclusion models suggesting that cells have a larger repertoire for generating inclusions than currently thought, and imply that toxicity in ALS does not stem from a particular aggregation process or aggregate structure.
Journal ArticleDOI
Proteome Homeostasis Dysfunction: A Unifying Principle in ALS Pathogenesis.
Justin J. Yerbury,Justin J. Yerbury,Natalie E. Farrawell,Natalie E. Farrawell,Luke McAlary,Luke McAlary +5 more
TL;DR: It is proposed that stratification will appear that might dictate the efficacy of therapeutics based on the proteostasis network, and all genetic lesions associated with ALS (including in mRNA-binding proteins) cause widespread imbalance to an already metastable proteome.
Journal ArticleDOI
SOD1A4V aggregation alters ubiquitin homeostasis in a cell model of ALS.
Natalie E. Farrawell,Natalie E. Farrawell,Isabella A. Lambert-Smith,Isabella A. Lambert-Smith,Kristen Mitchell,Kristen Mitchell,Jessie McKenna,Luke McAlary,Luke McAlary,Luke McAlary,Prajwal Ciryam,Prajwal Ciryam,Prajwal Ciryam,Kara L. Vine,Kara L. Vine,Darren N. Saunders,Justin J. Yerbury,Justin J. Yerbury +17 more
TL;DR: Misfolded SOD1 contributes to ubiquitin proteasome system dysfunction in a cell model of ALS and Ub homeostasis is an important target for monitoring pathological changes in ALS.
Journal ArticleDOI
SerpinB2 (PAI-2) Modulates Proteostasis via Binding Misfolded Proteins and Promotion of Cytoprotective Inclusion Formation
Jodi A. Lee,Justin J. Yerbury,Natalie E. Farrawell,Robert F. Shearer,Patrick Constantinescu,Danny M. Hatters,Wayne A. Schroder,Andreas Suhrbier,Mark R. Wilson,Darren N. Saunders,Marie Ranson +10 more
TL;DR: SerpinB2 plays an important role in proteostasis as its loss leads to a proteotoxic phenotype associated with an inability to compartmentalize aggregating proteins and a reduced capacity of the ubiquitin-proteasome system (UPS).