Vinod Sundaramoorthy

TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.

TL;DR: It is demonstrated that C9ORF72 regulates endosomal trafficking and colocalized with Rab proteins implicated in autophagy and endocytic transport, and increased colocalization between C9orF72 and Rab7 and Rab11 compared with controls, suggesting possible dysregulation of trafficking in patients bearing the C9 ORF72 repeat expansion.

TL;DR: In this article, the authors used genome-wide linkage analysis in a large ALS/FTD kindred to identify a novel disease locus on chromosome 16p13.3, which encodes cyclin F, a component of an E3 ubiquitin-protein ligase complex (SCFCyclin F).

TL;DR: It is demonstrated that pharmacological induction of ER stress causes TAR DNA binding protein 43 to accumulate in the cytoplasm, where TDP-43 also associates with stress granules (SGs) and forms large inclusions, providing evidence for ER stress as a pathogenic pathway in T DP-43-mediated disease.

TL;DR: New cellular mechanisms linking ALS with ataxin-2 intermediate length polyQ expansions are described and further evidence linking disruption to ER-Golgi compartments and FUS pathology in ALS is provided.