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Nathalie Forey
Researcher at International Agency for Research on Cancer
Publications - 20
Citations - 818
Nathalie Forey is an academic researcher from International Agency for Research on Cancer. The author has contributed to research in topics: Cancer & Population. The author has an hindex of 14, co-authored 17 publications receiving 687 citations. Previous affiliations of Nathalie Forey include Columbia University & Necker-Enfants Malades Hospital.
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Journal ArticleDOI
Rare, Evolutionarily Unlikely Missense Substitutions in ATM Confer Increased Risk of Breast Cancer
Sean V. Tavtigian,Peter J. Oefner,Davit Babikyan,Anne Hartmann,Sue Healey,Florence Le Calvez-Kelm,Fabienne Lesueur,Graham Byrnes,Shu Chun Chuang,Nathalie Forey,Corinna Feuchtinger,Lydie Gioia,Janet Hall,Mia Hashibe,Barbara Herte,Sandrine McKay-Chopin,Alun Thomas,Maxime Vallée,Catherine Voegele,Penelope M. Webb,David C. Whiteman,Suleeporn Sangrajrang,John L. Hopper,Melissa C. Southey,Irene L. Andrulis,Esther M. John,Esther M. John,Esther M. John,Georgia Chenevix-Trench +28 more
TL;DR: It is concluded that a comparison between the graded distributions of missense substitutions in cases versus controls can complement analyses of truncating variants and help identify susceptibility genes and that this approach will aid interpretation of the data emerging from new sequencing technologies.
Journal ArticleDOI
Rare key functional domain missense substitutions in MRE11A , RAD50 , and NBN contribute to breast cancer susceptibility: results from a Breast Cancer Family Registry case-control mutation-screening study
Francesca Damiola,Maroulio Pertesi,Javier Oliver,Florence Le Calvez-Kelm,Catherine Voegele,Erin L. Young,Nivonirina Robinot,Nathalie Forey,Geoffroy Durand,Maxime Vallée,Kayoko Tao,Terrell C Roane,Gareth J. Williams,John L. Hopper,John L. Hopper,Melissa C. Southey,Irene L. Andrulis,Esther M. John,Esther M. John,David E. Goldgar,Fabienne Lesueur,Fabienne Lesueur,Sean V. Tavtigian +22 more
TL;DR: It is established that MRE11A, RAD50, and NBN are intermediate-risk breast cancer susceptibility genes, and like ATM and CHEK2, their spectrum of pathogenic variants includes a relatively high proportion of missense substitutions.
Journal ArticleDOI
Rare, evolutionarily unlikely missense substitutions in CHEK2 contribute to breast cancer susceptibility: results from a breast cancer family registry case-control mutation-screening study
Florence Le Calvez-Kelm,Fabienne Lesueur,Francesca Damiola,Maxime Vallée,Catherine Voegele,Davit Babikyan,Geoffroy Durand,Nathalie Forey,Sandrine McKay-Chopin,Nivonirina Robinot,Tu Nguyen-Dumont,Alun Thomas,Graham Byrnes,John L. Hopper,Melissa C. Southey,Irene L. Andrulis,Esther M. John,Esther M. John,Sean V. Tavtigian +18 more
TL;DR: This study shows that CHEK2 harbors many rare sequence variants that confer increased risk of breast cancer and that a substantial proportion of these are missense substitutions, and provides a method to combine data from protein-truncating variants and rare missense substitution data into a one degree of freedom per gene test.
Journal ArticleDOI
Identification of novel long non-coding RNAs deregulated in hepatocellular carcinoma using RNA-sequencing
D Degli Esposti,Hector Hernandez-Vargas,Catherine Voegele,Nora Fernandez-Jimenez,Nathalie Forey,Brigitte Bancel,Florence Le Calvez-Kelm,James McKay,Philippe Merle,Zdenko Herceg +9 more
TL;DR: This study provides the most comprehensive compendium of lncRNAs expressed in HCC, as well as in control or cirrhotic livers and finds that more than 20% of differentially expressed lnc RNAs are associated to actively transcribed enhancers and that the co-expression patterns with their closest genes change dramatically during HCC development.
Journal ArticleDOI
Impaired Ig class switch in mice deficient for the X-linked lymphoproliferative disease gene Sap.
Umaima Al-Alem,Cuiling Li,Cuiling Li,Cuiling Li,Nathalie Forey,Nathalie Forey,Nathalie Forey,Francis Relouzat,Francis Relouzat,Francis Relouzat,Marie Claude Fondanèche,Marie Claude Fondanèche,Marie Claude Fondanèche,Sean V. Tavtigian,Sean V. Tavtigian,Sean V. Tavtigian,Zhao Qi Wang,Zhao Qi Wang,Zhao Qi Wang,Sylvain Latour,Sylvain Latour,Sylvain Latour,Luo Yin,Luo Yin,Luo Yin +24 more
TL;DR: It is shown that signaling lymphocytic activation molecule (SLAM)-associated protein (SAP) is expressed in B cells and this expression is down-regulated after stimulation with lipopolysaccharide (LPS) and interleukin 4 (IL-4) and this impairment correlates with reduced IgG and IgA production in vitro.