N
Nestor Gabriel Iglesias
Researcher at National University of Quilmes
Publications - 24
Citations - 1220
Nestor Gabriel Iglesias is an academic researcher from National University of Quilmes. The author has contributed to research in topics: Dengue virus & Flavivirus. The author has an hindex of 11, co-authored 21 publications receiving 1025 citations. Previous affiliations of Nestor Gabriel Iglesias include Fundación Instituto Leloir & National Scientific and Technical Research Council.
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Journal ArticleDOI
Dengue virus capsid protein usurps lipid droplets for viral particle formation
Marcelo M. Samsa,Juan Alberto Mondotte,Nestor Gabriel Iglesias,Iranaia Assunção-Miranda,Giselle Barbosa-Lima,Andrea T. Da Poian,Patrícia T. Bozza,Andrea V. Gamarnik +7 more
TL;DR: It is proposed that lipid droplets play multiple roles during the viral life cycle; they could sequester the viral capsid protein early during infection and provide a scaffold for genome encapsidation and a link between lipid droplet metabolism and viral replication is suggested.
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The Dengue Virus NS5 Protein Intrudes in the Cellular Spliceosome and Modulates Splicing
Federico Andres de Maio,Guillermo Risso,Nestor Gabriel Iglesias,Priya S. Shah,Berta Pozzi,Leopoldo German Gebhard,Pablo Mammi,Estefania Mancini,Marcelo J. Yanovsky,Raul Andino,Nevan J. Krogan,Anabella Srebrow,Andrea V. Gamarnik +12 more
TL;DR: A novel function of NS5 in the nucleus where it interferes with cellular splicing is demonstrated and it is proposed that NS5 binding to U5 snRNP proteins hijacks the splicing machinery resulting in a less restrictive environment for viral replication.
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RNA Sequences and Structures Required for the Recruitment and Activity of the Dengue Virus Polymerase
Claudia Veronica Filomatori,Nestor Gabriel Iglesias,Sergio Villordo,Diego E. Alvarez,Andrea V. Gamarnik +4 more
TL;DR: It is proposed that the long range RNA-RNA interactions in the viral genome play multiple roles during RNA synthesis, and new molecular details about the promoter-dependent dengue virus RNA polymerase activity are provided.
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Dengue Virus Genome Uncoating Requires Ubiquitination
Laura Andrea Byk,Nestor Gabriel Iglesias,Federico Andres de Maio,Leopoldo German Gebhard,Mario Rossi,Andrea V. Gamarnik +5 more
TL;DR: The fate of nucleocapsid components (capsid protein and viral genome) during the infection process is investigated and found that capsid is degraded by the ubiquitin-proteasome system, in contrast to that observed for other RNA and DNA viruses.
Journal ArticleDOI
Overlapping Local and Long-Range RNA-RNA Interactions Modulate Dengue Virus Genome Cyclization and Replication
Luana de Borba,Sergio Villordo,Nestor Gabriel Iglesias,Claudia Veronica Filomatori,Leopoldo German Gebhard,Andrea V. Gamarnik +5 more
TL;DR: New cis-acting elements present in the capsid coding sequence that facilitate cyclization of the viral RNA by hybridization with a sequence involved in a local dumbbell structure at the viral 3′ untranslated region (UTR) are identified.