N
Nicholas J. Cooper
Researcher at University of Cambridge
Publications - 40
Citations - 3446
Nicholas J. Cooper is an academic researcher from University of Cambridge. The author has contributed to research in topics: Cognition & Genome-wide association study. The author has an hindex of 27, co-authored 40 publications receiving 2926 citations. Previous affiliations of Nicholas J. Cooper include Public Health England & Wellcome Trust.
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Journal ArticleDOI
Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers.
Suna Onengut-Gumuscu,Wei-Min Chen,Oliver S. Burren,Nicholas J. Cooper,Aaron R. Quinlan,Josyf C. Mychaleckyj,Emily Farber,Jessica K. Bonnie,Michal Szpak,Ellen Schofield,Premanand Achuthan,Hui Guo,Mary D Fortune,Helen Stevens,Neil Walker,Lucas D. Ward,Anshul Kundaje,Manolis Kellis,Mark J. Daly,Jeffrey C. Barrett,Jason D. Cooper,Panos Deloukas,John A. Todd,Chris Wallace,Patrick Concannon,Stephen S. Rich +25 more
TL;DR: In this paper, a Bayesian approach was used to define credible sets for the T1D-associated SNPs localized to enhancer sequences active in thymus, T and B cells, and CD34(+) stem cells.
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Widespread seasonal gene expression reveals annual differences in human immunity and physiology
Xaquin Castro Dopico,Marina Evangelou,Ricardo C. Ferreira,Hui Guo,Marcin L. Pekalski,Deborah J. Smyth,Nicholas J. Cooper,Oliver S. Burren,Anthony J. C. Fulford,Branwen J. Hennig,Andrew M. Prentice,Anette-G. Ziegler,Ezio Bonifacio,Chris Wallace,John A. Todd +14 more
TL;DR: The immune system has a profound pro-inflammatory transcriptomic profile during European winter, with increased levels of soluble IL-6 receptor and C-reactive protein, risk biomarkers for cardiovascular, psychiatric and autoimmune diseases that have peak incidences in winter.
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Preliminary validity of "integneuro": a new computerized battery of neurocognitive tests.
Robert H. Paul,Jeffrey Lawrence,Leanne M. Williams,C Clark Richard,Nicholas J. Cooper,Evian Gordon +5 more
TL;DR: Results support the use of IntegNeuroTM as a computerized cognitive system and additional studies are needed to examine the clinical utility of the battery.
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Capture Hi-C reveals novel candidate genes and complex long-range interactions with related autoimmune risk loci
Paul Martin,Amanda McGovern,Gisela Orozco,Kate Duffus,Annie Yarwood,Stefan Schoenfelder,Nicholas J. Cooper,Anne Barton,Chris Wallace,Peter Fraser,Jane Worthington,Steve Eyre +11 more
TL;DR: umerous looping interactions are reported and evidence that only a minority of interactions are common to both B- and T-cell lines is provided, suggesting interactions may be highly cell-type specific.
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International Study to Predict Optimized Treatment for Depression (iSPOT-D), a randomized clinical trial: rationale and protocol.
Leanne M. Williams,A. John Rush,Stephen H. Koslow,Stephen R. Wisniewski,Nicholas J. Cooper,Charles B. Nemeroff,Alan F. Schatzberg,Evian Gordon +7 more
TL;DR: iSPOT-D evaluates clinical and biological predictors of treatment response in the largest known sample of MDD collected worldwide, and develops a model that incorporates multiple predictors and moderators.