M
Mary D Fortune
Researcher at University of Cambridge
Publications - 23
Citations - 1434
Mary D Fortune is an academic researcher from University of Cambridge. The author has contributed to research in topics: Genome-wide association study & Single-nucleotide polymorphism. The author has an hindex of 11, co-authored 17 publications receiving 986 citations. Previous affiliations of Mary D Fortune include Wellcome Trust Sanger Institute.
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Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers.
Suna Onengut-Gumuscu,Wei-Min Chen,Oliver S. Burren,Nicholas J. Cooper,Aaron R. Quinlan,Josyf C. Mychaleckyj,Emily Farber,Jessica K. Bonnie,Michal Szpak,Ellen Schofield,Premanand Achuthan,Hui Guo,Mary D Fortune,Helen Stevens,Neil Walker,Lucas D. Ward,Anshul Kundaje,Manolis Kellis,Mark J. Daly,Jeffrey C. Barrett,Jason D. Cooper,Panos Deloukas,John A. Todd,Chris Wallace,Patrick Concannon,Stephen S. Rich +25 more
TL;DR: In this paper, a Bayesian approach was used to define credible sets for the T1D-associated SNPs localized to enhancer sequences active in thymus, T and B cells, and CD34(+) stem cells.
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Integration of disease association and eQTL data using a Bayesian colocalisation approach highlights six candidate causal genes in immune-mediated diseases
TL;DR: The utility of integrating genetic studies of disease and gene expression for highlighting causal genes and cell types is demonstrated, including for CTSH, the expression of which in monocytes, but not in B cells, may mediate type 1 diabetes and narcolepsy associations in the chromosome 15q25.1 region.
Journal ArticleDOI
Statistical colocalization of genetic risk variants for related autoimmune diseases in the context of common controls
Mary D Fortune,Hui Guo,Oliver S. Burren,Ellen Schofield,Neil Walker,Maria Ban,Stephen Sawcer,John Bowes,Jane Worthington,Anne Barton,Steve Eyre,John A. Todd,Chris Wallace +12 more
TL;DR: Two colocalization methods are extended to allow for the shared-control design commonly used in comparison of genome-wide association study results across diseases, suggesting a shared cellular etiology of autoimmune diseases.
Journal ArticleDOI
Uganda Genome Resource Enables Insights into Population History and Genomic Discovery in Africa
Deepti Gurdasani,Tommy Carstensen,Segun Fatumo,Guanjie Chen,Chris S Franklin,Javier Prado-Martinez,Heleen J. Bouman,Federico Abascal,Marc Haber,Ioanna Tachmazidou,Iain Mathieson,Kenneth Ekoru,Kenneth Ekoru,Marianne K. DeGorter,Rebecca N Nsubuga,Chris Finan,Eleanor Wheeler,Eleanor Wheeler,Li Chen,David Neil Cooper,Stephen Schiffels,Yuan Chen,Graham R. S. Ritchie,Martin O. Pollard,Mary D Fortune,Alexander J. Mentzer,Erik Garrison,Anders Bergström,Konstantinos Hatzikotoulas,Adebowale Adeyemo,Ayo P. Doumatey,Heather Elding,Louise V. Wain,Louise V. Wain,Georg Ehret,Georg Ehret,Paul L. Auer,Charles Kooperberg,Alexander P. Reiner,Alexander P. Reiner,Nora Franceschini,Dermot Maher,Stephen B. Montgomery,Stephen B. Montgomery,Carl M. Kadie,Chris Widmer,Yali Xue,Janet Seeley,Gershim Asiki,Anatoli Kamali,Elizabeth H. Young,Elizabeth H. Young,Cristina Pomilla,Cristina Pomilla,Nicole Soranzo,Nicole Soranzo,Nicole Soranzo,Eleftheria Zeggini,Fraser J. Pirie,Andrew P. Morris,Andrew P. Morris,David Heckerman,Chris Tyler-Smith,Ayesha A. Motala,Charles N. Rotimi,Pontiano Kaleebu,Inês Barroso,Inês Barroso,M. S. Sandhu +68 more
TL;DR: The largest study of its kind, comprising genome-wide data from 6,400 individuals and whole-genome sequences from rural Uganda, finds evidence of geographically correlated fine-scale population substructure.
Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers
Suna Onengut-Gumuscu,Wei-Min Chen,Oliver S. Burren,Emily Farber,Michal Szpak,Ellen Schofield,Premanand Achuthan,Hui Guo,Helen Stevens,Anshul Kundaje,Manolis Kellis,Panos Deloukas,Chris Wallace,Patrick Concannon,Nicholas J. Cooper,Aaron R. Quinlan,Josyf C. Mychaleckyj,Jessica K. Bonnie,Mary D Fortune,Neil Walker,Lucas D. Ward,Mark J. Daly,Jeffrey C. Barrett,Jason D. Cooper,John A. Todd,Stephen S. Rich +25 more
TL;DR: A comparative analysis with 15 immune diseases showed that T1D is more similar genetically to other autoantibody-positive diseases, significantly most similar to juvenile idiopathic arthritis and significantly least similar to ulcerative colitis, and provided support for three additional new T1d risk loci.