Nick D.L. Owens

TL;DR: It is shown that the aryl hydrocarbon receptor (AhR), a transcription factor that senses environmental stimuli, modulates pathology in psoriasis and suggests a critical role for AhR in the regulation of inflammatory responses and opens the possibility for novel therapeutic strategies in chronic inflammatory disorders.

TL;DR: By ultra-high-frequency sampling of Xenopus embryos and absolute normalization of sequence reads, this analysis provides unprecedented insight into the reorganization of maternal and embryonic transcripts and redefines the ability to perform quantitative biology.

TL;DR: It is argued that AIS are much more than engineered systems inspired by the immune system and that there is a great deal for both immunology and engineering to learn from each other through working in an interdisciplinary manner.

TL;DR: In vivo genome-wide regulatory inputs of the T-box proteins Brachyury, Eomesodermin, and VegT, which together maintain neuromesodermal stem cells and determine their bipotential fates in frog embryos, are defined to ensure the continuous formation of correctly proportioned neural and mesodermal tissues in vertebrate embryos during axial elongation.

TL;DR: Experimental analysis and high-resolution expression profiling indicate that the polyadenylation of maternal transcripts is necessary for the establishment of proper levels of zygotic transcription at the MBT, and that genes activated in the second wave of expression contribute to the regulation of genes expressed in the third.