Paul Piccinelli

TL;DR: Analyses of the assembly indicate that two whole-genome duplications likely occurred before the divergence of ancestral lamprey and gnathostome lineages, and help define key evolutionary events within vertebrate lineages.

TL;DR: In vivo genome-wide regulatory inputs of the T-box proteins Brachyury, Eomesodermin, and VegT, which together maintain neuromesodermal stem cells and determine their bipotential fates in frog embryos, are defined to ensure the continuous formation of correctly proportioned neural and mesodermal tissues in vertebrate embryos during axial elongation.

TL;DR: This work identifies ancient functional signatures within vertebrate conserved non-coding elements (CNEs) through a combination of phylogenetic footprinting and functional assay, using genomic sequence from the sea lamprey as a reference, and reveals a striking enrichment within vertebrates for conserved binding-site motifs of the Pbx-Hox hetero-dimer.

TL;DR: In this paper, the authors focus on the microbial community structure of iron oxyhydroxide minerals that often occur in tight association with microbial life, referred to as Biogenic Iron Oxyhydroxides (BIOS).

TL;DR: In this article , a prospective pilot study including eleven children with profound bilateral hearing loss who underwent cochlear implant surgery was performed with whole exome sequencing (WES) complemented with XONarray to identify copy number variants, using a manually curated gene panel incorporating 179 genes associated with non-syndromic and syndromic SNHL.