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Nicola Voyle
Researcher at King's College London
Publications - 12
Citations - 1775
Nicola Voyle is an academic researcher from King's College London. The author has contributed to research in topics: Population & Alzheimer's disease. The author has an hindex of 8, co-authored 12 publications receiving 1109 citations.
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Journal ArticleDOI
Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk.
Iris E. Jansen,Jeanne E. Savage,Kyoko Watanabe,Julien Bryois,Dylan M. Williams,Stacy Steinberg,Julia Sealock,Ida K. Karlsson,Ida K. Karlsson,Sara Hägg,Lavinia Athanasiu,Lavinia Athanasiu,Nicola Voyle,Petroula Proitsi,Aree Witoelar,Sven Stringer,Dag Aarsland,Dag Aarsland,Ina S. Almdahl,Ina S. Almdahl,Ina S. Almdahl,Fred Andersen,Sverre Bergh,Francesco Bettella,Sigurbjorn Bjornsson,Anne Brækhus,Geir Bråthen,Christiaan de Leeuw,Rahul S. Desikan,Srdjan Djurovic,Srdjan Djurovic,Logan Dumitrescu,Tormod Fladby,Tormod Fladby,Timothy J. Hohman,Palmi V. Jonsson,Steven J. Kiddle,Arvid Rongve,Ingvild Saltvedt,Sigrid Botne Sando,Geir Selbæk,Maryam Shoai,Nathan G. Skene,Nathan G. Skene,Jon Snaedal,Eystein Stordal,Eystein Stordal,Ingun Ulstein,Yunpeng Wang,Linda R. White,John Hardy,Jens Hjerling-Leffler,Patrick F. Sullivan,Patrick F. Sullivan,Wiesje M. van der Flier,Richard Dobson,Lea K. Davis,Hreinn Stefansson,Kari Stefansson,Nancy L. Pedersen,Stephan Ripke,Stephan Ripke,Stephan Ripke,Ole A. Andreassen,Danielle Posthuma,Danielle Posthuma +65 more
TL;DR: A large genome-wide association study of clinically diagnosed AD and AD-by-proxy identifies new loci and functional pathways that contribute to AD risk and adds novel insights into the neurobiology of AD.
Journal ArticleDOI
Circulating Proteomic Signatures of Chronological Age
Cristina Menni,Steven J. Kiddle,Massimo Mangino,Ana Viñuela,Maria Psatha,Claire J. Steves,Martina Sattlecker,Alfonso Buil,Stephen Newhouse,Sally K. Nelson,Stephen Williams,Nicola Voyle,Hilkka Soininen,Iwona Kłoszewska,Patrizia Mecocci,Magda Tsolaki,Bruno Vellas,Simon Lovestone,Tim D. Spector,Richard Dobson,Ana M. Valdes +20 more
TL;DR: The importance of proteomics to identify some molecular mechanisms involved in human health and aging is highlighted and the importance of RNAseq data from whole blood in TwinsUK is highlighted.
Journal ArticleDOI
Blood Protein Markers of Neocortical Amyloid-β Burden: A Candidate Study Using SOMAscan Technology.
Nicola Voyle,David Baker,Samantha C. Burnham,Antonia Covin,Zhanpan Zhang,Dipen Sangurdekar,Cristina Tan Hehir,Chantal Bazenet,Chantal Bazenet,Simon Lovestone,Simon Lovestone,Steven J. Kiddle,Richard Dobson,Richard Dobson +13 more
TL;DR: Investigating whether previously identified blood proteins also show evidence for association with NAB in serum samples from the Australian Imaging, Biomarker and Lifestyle Flagship Study of Ageing (AIBL) aimed to investigate, and demonstrated the association of PPY and IgM with NB, despite technical differences between studies.
Posted ContentDOI
Genetic meta-analysis identifies 10 novel loci and functional pathways for Alzheimer's disease risk
Iris E. Jansen,Iris E. Jansen,Jeanne E. Savage,Kyoko Watanabe,Julien Bryois,Dylan M. Williams,Stacy Steinberg,Julia Sealock,Ida K. Karlsson,Sara Hägg,Lavinia Athanasiu,Lavinia Athanasiu,Nicola Voyle,Petroula Proitsi,Aree Witoelar,Sven Stringer,Dag Aarsland,Dag Aarsland,Ina S. Almdahl,Ina S. Almdahl,Fred Andersen,Sverre Bergh,Francesco Bettella,Sigurbjorn Bjornsson,Anne Brækhus,Geir Bråthen,Christiaan de Leeuw,Rahul S. Desikan,Srdjan Djurovic,Srdjan Djurovic,Logan Dumitrescu,Tormod Fladby,Tormod Fladby,Timothy Homan,Palmi V. Jonsson,Steven J. Kiddle,K Arvid Rongve,Ingvild Saltvedt,Sigrid Botne Sando,Geir Selbæk,Nathan Skenne,Jon Snaedal,Eystein Stordal,Eystein Stordal,Ingun Ulstein,Yunpeng Wang,Linda R. White,Jens Hjerling-Leffler,Patrick F. Sullivan,Patrick F. Sullivan,Wiesje M. van der Flier,Richard Dobson,Richard Dobson,Lea K. Davis,Hreinn Stefansson,Kari Stefansson,Nancy L. Pedersen,Stephan Ripke,Stephan Ripke,Ole A. Andreassen,Danielle Posthuma,Danielle Posthuma +61 more
TL;DR: The largest genome-wide association study of clinically diagnosed AD and AD-by-proxy and Mendelian randomisation results suggest a protective effect of cognitive ability on AD risk and a step forward in identifying more of the genetic factors that contribute to AD risk.
Journal ArticleDOI
A Pathway Based Classification Method for Analyzing Gene Expression for Alzheimer's Disease Diagnosis.
Nicola Voyle,Aoife Keohane,Stephen Newhouse,Katie Lunnon,Caroline Johnston,Hilkka Soininen,Iwona Kłoszewska,Patrizia Mecocci,Magda Tsolaki,Bruno Vellas,Simon Lovestone,Simon Lovestone,Angela Hodges,Steven J. Kiddle,Richard Dobson +14 more
TL;DR: Whether a case/control classification model built on pathway level data was more robust than a gene level model and may consequently perform better in test data has not lead to a greater predictive ability in these datasets.