S
Sara Hägg
Researcher at Karolinska Institutet
Publications - 179
Citations - 10211
Sara Hägg is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Medicine & Mendelian randomization. The author has an hindex of 38, co-authored 146 publications receiving 7212 citations. Previous affiliations of Sara Hägg include Uppsala University & Science for Life Laboratory.
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Journal ArticleDOI
Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk.
Iris E. Jansen,Jeanne E. Savage,Kyoko Watanabe,Julien Bryois,Dylan M. Williams,Stacy Steinberg,Julia Sealock,Ida K. Karlsson,Ida K. Karlsson,Sara Hägg,Lavinia Athanasiu,Lavinia Athanasiu,Nicola Voyle,Petroula Proitsi,Aree Witoelar,Sven Stringer,Dag Aarsland,Dag Aarsland,Ina S. Almdahl,Ina S. Almdahl,Ina S. Almdahl,Fred Andersen,Sverre Bergh,Francesco Bettella,Sigurbjorn Bjornsson,Anne Brækhus,Geir Bråthen,Christiaan de Leeuw,Rahul S. Desikan,Srdjan Djurovic,Srdjan Djurovic,Logan Dumitrescu,Tormod Fladby,Tormod Fladby,Timothy J. Hohman,Palmi V. Jonsson,Steven J. Kiddle,Arvid Rongve,Ingvild Saltvedt,Sigrid Botne Sando,Geir Selbæk,Maryam Shoai,Nathan G. Skene,Nathan G. Skene,Jon Snaedal,Eystein Stordal,Eystein Stordal,Ingun Ulstein,Yunpeng Wang,Linda R. White,John Hardy,Jens Hjerling-Leffler,Patrick F. Sullivan,Patrick F. Sullivan,Wiesje M. van der Flier,Richard Dobson,Lea K. Davis,Hreinn Stefansson,Kari Stefansson,Nancy L. Pedersen,Stephan Ripke,Stephan Ripke,Stephan Ripke,Ole A. Andreassen,Danielle Posthuma,Danielle Posthuma +65 more
TL;DR: A large genome-wide association study of clinically diagnosed AD and AD-by-proxy identifies new loci and functional pathways that contribute to AD risk and adds novel insights into the neurobiology of AD.
Journal ArticleDOI
Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence
Jeanne E. Savage,Philip R. Jansen,Philip R. Jansen,Sven Stringer,Kyoko Watanabe,Julien Bryois,Christiaan de Leeuw,Mats Nagel,Swapnil Awasthi,Peter B. Barr,Jonathan R. I. Coleman,Katrina L. Grasby,Anke R. Hammerschlag,Jakob Kaminski,Robert Karlsson,Eva Krapohl,Max Lam,Marianne Nygaard,Chandra A. Reynolds,Joey W. Trampush,Hannah Young,Delilah Zabaneh,Sara Hägg,Narelle K. Hansell,Ida K. Karlsson,Sten Linnarsson,Grant W. Montgomery,Grant W. Montgomery,Ana B. Muñoz-Manchado,Erin Burke Quinlan,Gunter Schumann,Nathan G. Skene,Nathan G. Skene,Bradley T. Webb,Tonya White,Dan E. Arking,Dimitrios Avramopoulos,Robert M. Bilder,Panos Bitsios,Katherine E. Burdick,Katherine E. Burdick,Katherine E. Burdick,Tyrone D. Cannon,Ornit Chiba-Falek,Andrea Christoforou,Elizabeth T. Cirulli,Eliza Congdon,Aiden Corvin,Gail Davies,Ian J. Deary,Pamela DeRosse,Pamela DeRosse,Dwight Dickinson,Srdjan Djurovic,Srdjan Djurovic,Gary Donohoe,Emily Drabant Conley,Johan G. Eriksson,Thomas Espeseth,Nelson A. Freimer,Stella G. Giakoumaki,Ina Giegling,Michael Gill,David C. Glahn,Ahmad R. Hariri,Alex Hatzimanolis,Alex Hatzimanolis,Matthew C. Keller,Emma Knowles,Deborah C. Koltai,Bettina Konte,Jari Lahti,Stephanie Le Hellard,Todd Lencz,Todd Lencz,David C. Liewald,Edythe D. London,Astri J. Lundervold,Anil K. Malhotra,Anil K. Malhotra,Ingrid Melle,Ingrid Melle,Derek W. Morris,Anna C. Need,William Ollier,Aarno Palotie,Aarno Palotie,Aarno Palotie,Antony Payton,Neil Pendleton,Russell A. Poldrack,Katri Räikkönen,Ivar Reinvang,Panos Roussos,Panos Roussos,Dan Rujescu,Fred W. Sabb,Matthew A. Scult,Olav B. Smeland,Nikolaos Smyrnis,Nikolaos Smyrnis,John M. Starr,Vidar M. Steen,Nikos C. Stefanis,Nikos C. Stefanis,Richard E. Straub,Kjetil Sundet,Henning Tiemeier,Aristotle N. Voineskos,Daniel R. Weinberger,Elisabeth Widen,Jin Yu,Gonçalo R. Abecasis,Ole A. Andreassen,Gerome Breen,Lene Christiansen,Birgit Debrabant,Danielle M. Dick,Andreas Heinz,Jens Hjerling-Leffler,M. Arfan Ikram,Kenneth S. Kendler,Nicholas G. Martin,Sarah E. Medland,Nancy L. Pedersen,Robert Plomin,Tinca J. C. Polderman,Stephan Ripke,Stephan Ripke,Stephan Ripke,Sophie van der Sluis,Patrick Sullivan,Patrick Sullivan,Scott I. Vrieze,Margaret J. Wright,Danielle Posthuma +135 more
TL;DR: A large-scale genetic association study of intelligence identifies 190 new loci and implicates 939 new genes related to neurogenesis, neuron differentiation and synaptic structure, a major step forward in understanding the neurobiology of cognitive function as well as genetically related neurological and psychiatric disorders.
Journal ArticleDOI
GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational Attainment
Cornelius A. Rietveld,Sarah E. Medland,Jaime Derringer,Jian Yang,Tõnu Esko,Nicolas W. Martin,Nicolas W. Martin,Harm-Jan Westra,Konstantin Shakhbazov,Abdel Abdellaoui,Arpana Agrawal,Eva Albrecht,Behrooz Z. Alizadeh,Najaf Amin,John Barnard,Sebastian E. Baumeister,Kelly S. Benke,Lawrence F. Bielak,Jeffrey A. Boatman,Patricia A. Boyle,Gail Davies,Christiaan de Leeuw,Niina Eklund,Niina Eklund,Daniel S. Evans,Rudolf Ferhmann,Krista Fischer,Christian Gieger,Håkon K. Gjessing,Sara Hägg,Sara Hägg,Jennifer R. Harris,Caroline Hayward,Christina Holzapfel,Carla A. Ibrahim-Verbaas,Erik Ingelsson,Erik Ingelsson,Bo Jacobsson,Bo Jacobsson,Peter K. Joshi,Astanand Jugessur,Marika Kaakinen,Stavroula Kanoni,Juha Karjalainen,Ivana Kolcic,Kati Kristiansson,Kati Kristiansson,Zoltán Kutalik,Zoltán Kutalik,Jari Lahti,Sang Hong Lee,Peng Lin,Penelope A. Lind,Yongmei Liu,Kurt Lohman,Marisa Loitfelder,George McMahon,Pedro Marques Vidal,Osorio Meirelles,Lili Milani,Ronny Myhre,Marja-Liisa Nuotio,Marja-Liisa Nuotio,Christopher Oldmeadow,Katja Petrovic,Wouter J. Peyrot,Ozren Polasek,Lydia Quaye,Eva Reinmaa,John P. Rice,Thais S. Rizzi,Helena Schmidt,Reinhold Schmidt,Albert V. Smith,Jennifer A. Smith,Toshiko Tanaka,Antonio Terracciano,Antonio Terracciano,Matthijs J. H. M. van der Loos,Veronique Vitart,Henry Völzke,Jürgen Wellmann,Lei Yu,Wei Zhao,Jüri Allik,John Attia,Stefania Bandinelli,François Bastardot,Jonathan P. Beauchamp,David A. Bennett,Klaus Berger,Laura J. Bierut,Dorret I. Boomsma,Ute Bültmann,Harry Campbell,Christopher F. Chabris,Lynn Cherkas,Mina K. Chung,Francesco Cucca,Francesco Cucca,Mariza de Andrade,Philip L. De Jager,Jan-Emmanuel De Neve,Jan-Emmanuel De Neve,Ian J. Deary,George Dedoussis,Panos Deloukas,Maria Dimitriou,Guoný Eiríksdóttir,Martin F. Elderson,Johan G. Eriksson,David M. Evans,Jessica D. Faul,Luigi Ferrucci,Melissa E. Garcia,Henrik Grönberg,Vilmundur Guonason,Per Hall,Juliette Harris,Tamara B. Harris,Nicholas D. Hastie,Andrew C. Heath,Dena G. Hernandez,Wolfgang Hoffmann,Adriaan Hofman,Rolf Holle,Elizabeth G. Holliday,Jouke-Jan Hottenga,William G. Iacono,Thomas Illig,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Mika Kähönen,Jaakko Kaprio,Jaakko Kaprio,Robert M. Kirkpatrick,Matthew Kowgier,Antti Latvala,Antti Latvala,Lenore J. Launer,Debbie A Lawlor,Terho Lehtimäki,Jingmei Li,Paul Lichtenstein,Peter Lichtner,David C. Liewald,Pamela A. F. Madden,Patrik K. E. Magnusson,Tomi E. Mäkinen,Marco Masala,Matt McGue,Andres Metspalu,Andreas Mielck,Michael B. Miller,Grant W. Montgomery,Sutapa Mukherjee,Sutapa Mukherjee,Dale R. Nyholt,Ben A. Oostra,Lyle J. Palmer,Aarno Palotie,Aarno Palotie,Brenda W.J.H. Penninx,Markus Perola,Markus Perola,Markus Perola,Patricia A. Peyser,Martin Preisig,Katri Räikkönen,Olli T. Raitakari,Anu Realo,Susan M. Ring,Samuli Ripatti,Samuli Ripatti,Samuli Ripatti,Fernando Rivadeneira,Igor Rudan,Aldo Rustichini,Veikko Salomaa,Antti-Pekka Sarin,David Schlessinger,Rodney J. Scott,Harold Snieder,Beate St Pourcain,John M. Starr,Jae Hoon Sul,Ida Surakka,Ida Surakka,Rauli Svento,Alexander Teumer,Henning Tiemeier,Frank J. A. van Rooij,David R. Van Wagoner,Erkki Vartiainen,Jorma Viikari,Peter Vollenweider,Judith M. Vonk,Gérard Waeber,David R. Weir,H.-Erich Wichmann,Elisabeth Widen,Gonneke Willemsen,James F. Wilson,Alan F. Wright,Dalton Conley,George Davey-Smith,Lude Franke,Patrick J. F. Groenen,Albert Hofman,Magnus Johannesson,Sharon L.R. Kardia,Robert F. Krueger,David Laibson,Nicholas G. Martin,Michelle N. Meyer,Michelle N. Meyer,Danielle Posthuma,Danielle Posthuma,Roy Thurik,Nicholas J. Timpson,André G. Uitterlinden,Cornelia M. van Duijn,Cornelia M. van Duijn,Peter M. Visscher,Peter M. Visscher,Daniel J. Benjamin,David Cesarini,David Cesarini,David Cesarini,Philipp Koellinger +230 more
TL;DR: In this article, a genome-wide association study of educational attainment was conducted in a discovery sample of 101,069 individuals and a replication sample of 25,490 individuals, and three independent SNPs are genome wide significant (rs9320913, rs11584700, rs4851266).
Journal ArticleDOI
Identification of seven loci affecting mean telomere length and their association with disease
Veryan Codd,Christopher P. Nelson,Eva Albrecht,Massimo Mangino,Joris Deelen,Jessica L. Buxton,Jouke-Jan Hottenga,Krista Fischer,Tõnu Esko,Ida Surakka,Linda Broer,Dale R. Nyholt,Irene Mateo Leach,Perttu Salo,Sara Hägg,Mary K. Matthews,Jutta Palmen,Giuseppe Danilo Norata,Paul F. O'Reilly,Danish Saleheen,Najaf Amin,Anthony J. Balmforth,Marian Beekman,Rudolf A. de Boer,Stefan Böhringer,Peter S. Braund,Paul Burton,Anton J. M. de Craen,Matthew Denniff,Yanbin Dong,Konstantinos Douroudis,Elena Dubinina,Johan G. Eriksson,Katia Garlaschelli,Dehuang Guo,Anna-Liisa Hartikainen,Anjali K. Henders,Jeanine J. Houwing-Duistermaat,Laura Kananen,Lennart C. Karssen,Johannes Kettunen,Norman Klopp,Vasiliki Lagou,Elisabeth M. van Leeuwen,Pamela A. F. Madden,Reedik Mägi,Patrik K. E. Magnusson,Satu Männistö,Satu Männistö,Mark I. McCarthy,Mark I. McCarthy,Mark I. McCarthy,Sarah E. Medland,Evelin Mihailov,Grant W. Montgomery,Ben A. Oostra,Aarno Palotie,Annette Peters,Helen Pollard,Anneli Pouta,Anneli Pouta,Inga Prokopenko,Samuli Ripatti,Veikko Salomaa,Veikko Salomaa,H. Eka D. Suchiman,Ana M. Valdes,Niek Verweij,Ana Viñuela,Xiaoling Wang,Xiaoling Wang,H-Erich Wichmann,Elisabeth Widen,Gonneke Willemsen,Margaret J. Wright,Kai Xia,Xiangjun Xiao,Dirk J. van Veldhuisen,Alberico L. Catapano,Martin D. Tobin,Alistair S. Hall,Alexandra I. F. Blakemore,Wiek H. van Gilst,Haidong Zhu,Haidong Zhu,Jeanette Erdmann,Muredach P. Reilly,Sekar Kathiresan,Sekar Kathiresan,Heribert Schunkert,Philippa J. Talmud,Nancy L. Pedersen,Markus Perola,Markus Perola,Markus Perola,Willem H. Ouwehand,Jaakko Kaprio,Nicholas G. Martin,Cornelia M. van Duijn,Iiris Hovatta,Iiris Hovatta,Christian Gieger,Andres Metspalu,Dorret I. Boomsma,Marjo-Riitta Järvelin,P. Eline Slagboom,John R Thompson,Tim D. Spector,Pim van der Harst,Nilesh J. Samani,Nilesh J. Samani +110 more
TL;DR: In this paper, a genome-wide meta-analysis of 37,684 individuals with replication of selected variants in an additional 10,739 individuals was carried out to identify seven loci, including five new loci associated with mean leukocyte telomere length (LTL) (P < 5 × 10−8).
Identification of seven loci affecting mean telomere length and their association with disease
Veryan Codd,Christopher P. Nelson,Eva Albrecht,Massimo Mangino,Joris Deelen,Jessica L. Buxton,Jouke-Jan Hottenga,Krista Fischer,Tõnu Esko,Ida Surakka,Linda Broer,Dale R. Nyholt,Irene Mateo Leach,Perttu Salo,Sara Hägg,Mary K. Matthews,Jutta Palmen,Giuseppe Danilo Norata,Paul F. O'Reilly,Danish Saleheen,Najaf Amin,Anthony J. Balmforth,Marian Beekman,Rudolf A. de Boer,Stefan Böhringer,Peter S. Braund,Paul Burton,Anton J. M. de Craen,Matthew Denniff,Yanbin Dong,Konstantinos Douroudis,Elena Dubinina,Johan G. Eriksson,Katia Garlaschelli,Dehuang Guo,Anna-Liisa Hartikainen,Anjali K. Henders,Jeanine J. Houwing-Duistermaat,Laura Kananen,Lennart C. Karssen,Johannes Kettunen,Norman Klopp,Vasiliki Lagou,Elisabeth M. van Leeuwen,Pamela A. F. Madden,Reedik Maegi,Patrik K. E. Magnusson,Satu Männistö,Mark I. McCarthy,Sarah E. Medland,Evelin Mihailov,Grant W. Montgomery,Ben A. Oostra,Aarno Palotie,Annette Peters,Helen Pollard,Anneli Pouta,Inga Prokopenko,Samuli Ripatti,Veikko Salomaa,H. Eka D. Suchiman,Ana M. Valdes,Niek Verweij,Ana Viñuela,Xiaoling Wang,H-Erich Wichmann,Elisabeth Widen,Gonneke Willemsen,Margaret J. Wright,Kai Xia,Xiangjun Xiao,Dirk J. van Veldhuisen,Alberico L. Catapano,Martin D. Tobin,Alistair S. Hall,Alexandra I. F. Blakemore,Wiek H. van Gilst,Haidong Zhu,Jeanette Erdmann,Muredach P. Reilly,Sekar Kathiresan,Heribert Schunkert,Philippa J. Talmud,Nancy L. Pedersen,Markus Perola,Willem H. Ouwehand,Jaakko Kaprio,Nicholas G. Martin,Cornelia M. van Duijn,Iris Hovatta,Christian Gieger,Andres Metspalu,Dorret I. Boomsma,Marjo-Riitta Järvelin,P. Eline Slagboom,John R Thompson,Tim D. Spector,Pim van der Harst,Nilesh J. Samani +98 more
TL;DR: In this article, a genome-wide meta-analysis of 37,684 individuals with replication of selected variants in an additional 10,739 individuals was carried out to identify seven loci, including five new loci associated with mean leukocyte telomere length (LTL).