Showing papers by "Nicolás Olea published in 2009"
University of Missouri1, Auburn University2, Prefectural University of Kumamoto3, University of Cincinnati4, Charité5, Maryville College6, University of Siena7, University of Florida8, Washington State University9, National Institutes of Natural Sciences, Japan10, Brunel University London11, University of Connecticut12, Emory University13, Goethe University Frankfurt14, University of Granada15, University of Parma16, Tufts University17, University of Würzburg18, North Carolina State University19, Chemical Heritage Foundation20, University of Texas Medical Branch21, University of Massachusetts Amherst22
TL;DR: Differences between industry-funded GLP studies of BPA conducted by commercial laboratories for regulatory purposes and non-GLP studies conducted in academic and government laboratories are reviewed to identify hazards and molecular mechanisms mediating adverse effects.
Abstract: BackgroundIn their safety evaluations of bisphenol A (BPA), the U.S. Food and Drug Administration (FDA) and a counterpart in Europe, the European Food Safety Authority (EFSA), have given special pr...
272 citations
TL;DR: Adipose tissue NP and OP levels are similar to the few data previously published in other countries, but further research is needed to determine trends in human exposure to these compounds and to investigate their consequences.
87 citations
TL;DR: The finding that women had three-fold higher levels of HCB than the men deserves further investigation, while exposure patterns differed between females and males.
67 citations
TL;DR: Concentrations of urinary 1-OHP were in the lower range of those generally reported for children living in non-polluted areas in Western Europe and the USA, which should be prevented due to the health consequences of the inadvertent exposure to PAH during development.
65 citations
TL;DR: According to the E-Screen and YES, TEXB alpha was ≥LOD in 70.0 and 55.0% of the placentas and 92.5 and 82.5% in beta, respectively; the interclass correlation coefficient was low and a fair level of agreement was observed after kappa test correction.
Abstract: We have standardized a method to assess the total effective xenoestrogen burden (TEXB) in human placentas by the extraction and separation by high-performance liquid chromatography of two fractions containing lipophilic xenoestrogens (alpha) and endogenous hormones (beta), followed by assessing their estrogenicity in MCF-7 breast cancer cell-based E-Screen and Yeast Estrogen Screen (YES) bioassays. The means of TEXB alpha concentrations (in estradiol equivalent (Eeq) units) were 1.32 and 0.77 Eeq pM g(-1) placenta in the E-Screen and YES, respectively; TEXB beta concentrations were 6.97 and 11.56 Eeq pM g(-1) placenta, respectively. The interclass correlation coefficient was low and a fair level of agreement was observed after kappa test correction. According to the E-Screen and YES, TEXB alpha was > or = LOD in 70.0 and 55.0% of the placentas and 92.5 and 82.5% in beta, respectively. Although both bioassays can be recommended for assessing TEXB, there is greater experience with the use of the E-Screen for estrogenic assessment after extensive extraction of complex human matrices.
26 citations
Journal Article•
TL;DR: The natural environment of these three French “departements” is widely recognised as being contaminated by the intense and excessive use of pesticides, the latter’s role in prostate cancer aetiology remains obscure, hence the need for a complete investigation, using reliable geographical, epidemiological and toxicological approaches.
Abstract: Prostate cancer is the fifth cause of cancer death in the world today. In spite of numerous studies on the subject, its aetiology has not yet been clearly defined. Three French “departements”, the French Antilles (Guadeloupe and Martinique) and French Guyana present unique epidemiological, geographical, ethnic and environmental characteristics which can help elucidate the complex causes behind the disease. These particular traits have been highlighted by a systematic scientific literature review, followed by the synthesis of current main aetiological hypotheses relative to the Caribbean-Guyanese context. Martinique and Guadeloupe register high world age-standardised incidence rates for prostate cancer (exceeding 150 cases per 100,000 in 2002), twice those of mainland France and in constant increase for the past 20 years, now making them comparable to the highest world incidence rates recorded amongst Afro-Americans in the United States of America. In Guyana, prostate cancer is also one of the commonest cancers in 2007. Ninety percent of the Caribbean population and 66% of the French Guyanese are of African descent. In these populations, favoured hypotheses for prostate cancer concern, along with genetic and ethnic factors, diet (change towards Western eating habits) and sexual behaviour (possible infectious cause such as a role for Human Papilloma Virus). The eventual implication of occupational risk factors (agriculture) shown in previous studies, as well as environmental factors such as pesticide exposure, need also to be examined. In the Caribbean-Guyanese context, no aetiological study has yet been published, even though abstracts and theses are available. While the natural environment of these three French “departements” is widely recognised as being contaminated by the intense and excessive use of pesticides, the latter’s role in prostate cancer aetiology remains obscure, hence the need for a complete investigation, using reliable geographical, epidemiological and toxicological approaches. Only full cooperation between complementary scientific teams will help acquire the necessary knowledge for the comprehension of this complex health problem and then for effective prevention. Such a study is currently being planned in synergy with local (Martinique, Guadeloupe, Guyana) and Bordeaux researchers, and with the collaboration of other European scientists.
1 citations