Patricia A. Hunt

TL;DR: New studies of humans and model organisms have shed new light on the complexity of meiotic defects, providing evidence that the age-related increase in errors in the human female is not attributable to a single factor but to an interplay between unique features of oogenesis and a host of endogenous and exogenous factors.

TL;DR: This document is a summary statement of the outcome from he meeting: “Bisphenol A: An Examination of the Relevance of cological, In vitro and Laboratory Animal Studies for Assessng Risks to Human Health” sponsored by both the NIEHS and IDCR at NIH/DHHS.

TL;DR: Some of the data that have led to conclusions that most aneuploidy derives from errors in maternal meiosis I, that maternal age is a risk factor for most, if not all, human trisomies, and that alterations in recombination are an important contributor to meiotic non-disjunction are summarized.

TL;DR: Based on reports that BPA impacts female reproduction and has the potential to affect male reproductive systems in humans and animals, BPA is a reproductive toxicant, which is considered an ovarian toxicant.

TL;DR: This review of the EDC literature as it relates to female health provides an important platform on which women's health can be improved and illustrates the sensitivity of early life-stage exposures.