N
Nicole Berndt
Researcher at Helmholtz-Zentrum Dresden-Rossendorf
Publications - 38
Citations - 1081
Nicole Berndt is an academic researcher from Helmholtz-Zentrum Dresden-Rossendorf. The author has contributed to research in topics: Chimeric antigen receptor & Immunotherapy. The author has an hindex of 14, co-authored 35 publications receiving 743 citations. Previous affiliations of Nicole Berndt include Dresden University of Technology & University of Düsseldorf.
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Journal ArticleDOI
Defective removal of ribonucleotides from DNA promotes systemic autoimmunity
Claudia Günther,Barbara Kind,Martin A M Reijns,Nicole Berndt,Manuel Martínez-Bueno,Christine Wolf,Victoria Tüngler,Osvaldo Chara,Osvaldo Chara,Young-Ae Lee,Norbert Hubner,Louise S. Bicknell,Sophia Blum,Claudia Krug,Franziska Schmidt,Stefanie Kretschmer,Sarah Koss,Katy R. Astell,Georgia Ramantani,Georgia Ramantani,Anja Bauerfeind,David L. Morris,Deborah S. Cunninghame Graham,Doryen Bubeck,Doryen Bubeck,Andrea Leitch,Stuart H. Ralston,Elizabeth A. Blackburn,Elizabeth A. Blackburn,M. Gahr,Torsten Witte,Timothy J. Vyse,Inga Melchers,Elisabeth Mangold,Markus M. Nöthen,Martin Aringer,Annegret Kuhn,K. Lüthke,L. Unger,Annette Bley,Alice Lorenzi,John D. Isaacs,Dimitra Alexopoulou,Karsten Conrad,Karsten Conrad,Andreas Dahl,Axel Roers,Axel Roers,Marta E. Alarcón-Riquelme,Marta E. Alarcón-Riquelme,Andrew P. Jackson,Min Ae Lee-Kirsch +51 more
TL;DR: It is determined that heterozygous parents of AGS patients exhibit an intermediate autoimmune phenotype and a genetic association between rare RNASEH2 sequence variants and SLE is demonstrated and a role of DNA damage-associated pathways in the initiation of autoimmunity is suggested.
Journal ArticleDOI
RPA and Rad51 constitute a cell intrinsic mechanism to protect the cytosol from self DNA.
Christine Wolf,Alexander Rapp,Nicole Berndt,Wolfgang Staroske,Max Schuster,Manuela Dobrick-Mattheuer,Stefanie Kretschmer,N. König,Thomas Kurth,Dagmar Wieczorek,Karin Kast,M. Cristina Cardoso,Claudia Günther,Min Ae Lee-Kirsch +13 more
TL;DR: It is shown that short ssDNA traverses the nuclear membrane, but is drawn into the nucleus by binding to the DNA replication and repair factors RPA and Rad51, which constitutes a cell intrinsic mechanism to protect the cytosol from self DNA.
Journal ArticleDOI
Costimulation improves the killing capability of T cells redirected to tumor cells expressing low levels of CD33: description of a novel modular targeting system
Claudia Arndt,Anja Feldmann,M von Bonin,Marc Cartellieri,E-M Ewen,Stefanie Koristka,Irene Michalk,Slava Stamova,Nicole Berndt,A Gocht,Martin Bornhäuser,G. Ehninger,Marc Schmitz,Michael Bachmann +13 more
TL;DR: It is observed that an efficient killing of tumor cells expressing low levels of the tumor target CD33 becomes critical at low effector-to-target cell ratios but can be improved by costimulation via CD137 using the novel targeting system described.
Journal ArticleDOI
Familial chilblain lupus due to a novel mutation in the exonuclease III domain of 3' repair exonuclease 1 (TREX1).
TL;DR: This case further implicates type I interferon-dependent innate immune activation in the pathogenesis of TREX1-associated familial chilblain lupus, suggesting a particular role of mutations within the catalytic exonuclease (Exo) III domain.
Journal ArticleDOI
“UniCAR”-modified off-the-shelf NK-92 cells for targeting of GD2-expressing tumour cells
Nicola Mitwasi,Anja Feldmann,Claudia Arndt,Stefanie Koristka,Nicole Berndt,Justyna Jureczek,Justyna Jureczek,Liliana R. Loureiro,Liliana R. Loureiro,Ralf Bergmann,Ralf Bergmann,Domokos Máthé,Nikolett Hegedüs,Tibor Kovács,Congcong Zhang,Congcong Zhang,Pranav Oberoi,Pranav Oberoi,Elke Jäger,Barbara Seliger,Claudia Rossig,Achim Temme,Achim Temme,Jiri Eitler,Torsten Tonn,Torsten Tonn,Marc Schmitz,Jessica C. Hassel,Dirk Jäger,Winfried S. Wels,Winfried S. Wels,Michael Bachmann +31 more
TL;DR: Proof of concept is provided that it is feasible to generate a universal off-the-shelf cellular therapeutic based on UniCAR NK-92 cells targeted to tumours expressing the disialoganglioside GD2 by GD2-specific TMs that are either based on an antibody-derived single-chain fragment variable (scFv) or an IgG4 backbone.