K
Karin Kast
Researcher at Dresden University of Technology
Publications - 113
Citations - 8347
Karin Kast is an academic researcher from Dresden University of Technology. The author has contributed to research in topics: Breast cancer & Population. The author has an hindex of 36, co-authored 108 publications receiving 6347 citations. Previous affiliations of Karin Kast include Helmholtz-Zentrum Dresden-Rossendorf & Mayo Clinic.
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Journal ArticleDOI
Risks of Breast, Ovarian, and Contralateral Breast Cancer for BRCA1 and BRCA2 Mutation Carriers
Karoline Kuchenbaecker,Karoline Kuchenbaecker,John L. Hopper,Daniel R. Barnes,Kelly-Anne Phillips,T.M. Mooij,Marie-José Roos-Blom,Marie-José Roos-Blom,Sarah Jervis,Sarah Jervis,Flora E. van Leeuwen,Roger L. Milne,Roger L. Milne,Nadine Andrieu,David E. Goldgar,Mary Beth Terry,Matti A. Rookus,Douglas F. Easton,Antonis C. Antoniou,Lesley McGuffog,D. Gareth Evans,Daniel Barrowdale,Debra Frost,Julian Adlard,Kai-ren Ong,Louise Izatt,Marc Tischkowitz,Ros Eeles,Rosemarie Davidson,Shirley Hodgson,Steve Ellis,Catherine Noguès,Christine Lasset,Dominique Stoppa-Lyonnet,Dominique Stoppa-Lyonnet,Jean-Pierre Fricker,Laurence Faivre,Pascaline Berthet,Maartje J. Hooning,Lizet E. van der Kolk,Carolien M. Kets,Muriel A. Adank,Esther M. John,Wendy K. Chung,Irene L. Andrulis,Irene L. Andrulis,Melissa C. Southey,Mary B. Daly,Saundra S. Buys,Ana Osorio,Christoph Engel,Karin Kast,Rita K. Schmutzler,Trinidad Caldés,Anna Jakubowska,Jacques Simard,Michael Friedlander,Sue-Anne McLachlan,Sue-Anne McLachlan,Eva Machackova,Lenka Foretova,Yen Y. Tan,Yen Y. Tan,Christian F. Singer,Edith Olah,Anne-Marie Gerdes,Brita Arver,Håkan Olsson +67 more
TL;DR: To estimate age-specific risks of breast, ovarian, and contralateral breast cancer for mutation carriers and to evaluate risk modification by family cancer history and mutation location, a large cohort study recruited in 1997-2011 provides estimates of cancer risk based on BRCA1 and BRCa2 mutation carrier status.
Journal ArticleDOI
Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene
Alfons Meindl,Heide Hellebrand,Constanze Wiek,Verena Erven,Barbara Wappenschmidt,Dieter Niederacher,Marcel Freund,Peter Lichtner,Linda Hartmann,Heiner Schaal,Juliane Ramser,Ellen Honisch,Christian Kubisch,Hans Erich Wichmann,Karin Kast,Helmut Deissler,Christoph Engel,Bertram Müller-Myhsok,Kornelia Neveling,Marion Kiechle,Christopher G. Mathew,Detlev Schindler,Rita K. Schmutzler,Helmut Hanenberg,Helmut Hanenberg +24 more
TL;DR: In index cases from 1,100 German families with gynecological malignancies, the first unambiguous evidence of highly penetrant mutations associated with human cancer in a RAD51 paralog is provided and support the 'common disease, rare allele' hypothesis.
Journal ArticleDOI
Pathology of Breast and Ovarian Cancers among BRCA1 and BRCA2 Mutation Carriers: Results from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA).
Nasim Mavaddat,Daniel Barrowdale,Irene L. Andrulis,Susan M. Domchek,Diana Eccles,Heli Nevanlinna,Susan J. Ramus,Amanda B. Spurdle,Mark E. Robson,Mark E. Sherman,Anna Marie Mulligan,Fergus J. Couch,Christoph Engel,Lesley McGuffog,Sue Healey,Olga M. Sinilnikova,Melissa C. Southey,Mary Beth Terry,David E. Goldgar,Frances P. O'Malley,Esther M. John,Ramunas Janavicius,Laima Tihomirova,Thomas Hansen,Finn Cilius Nielsen,Ana Osorio,Alexandra V. Stavropoulou,Javier Benitez,Siranoush Manoukian,Bernard Peissel,Monica Barile,Sara Volorio,Barbara Pasini,Riccardo Dolcetti,Anna Laura Putignano,Laura Ottini,Paolo Radice,Ute Hamann,Muhammad Usman Rashid,Frans B. L. Hogervorst,Mieke Kriege,Rob B. van der Luijt,Susan Peock,Debra Frost,D. Gareth Evans,Carole Brewer,Lisa Walker,Mark T. Rogers,Lucy Side,C. E. Houghton,Jo Ellen Weaver,Andrew K. Godwin,Rita K. Schmutzler,Barbara Wappenschmidt,Alfons Meindl,Karin Kast,Norbert Arnold,Dieter Niederacher,Christian Sutter,Helmut Deissler,Doroteha Gadzicki,Sabine Preisler-Adams,Raymonda Varon-Mateeva,Ines Schönbuchner,Heidrun Gevensleben,Dominique Stoppa-Lyonnet,Muriel Belotti,Laure Barjhoux,Claudine Isaacs,Beth N. Peshkin,Trinidad Caldés,Miguel De Al Hoya,Carmen Cañadas,Tuomas Heikkinen,Päivi Heikkilä,Kristiina Aittomäki,Ignacio Blanco,Conxi Lázaro,Joan Brunet,Bjarni A. Agnarsson,Adalgeir Arason,Rosa B. Barkardottir,Martine Dumont,Jacques Simard,Marco Montagna,Simona Agata,Emma D'Andrea,Max Yan,Stephen B. Fox,Timothy R. Rebbeck,Wendy S. Rubinstein,Nadine Tung,Judy Garber,Xianshu Wang,Zachary S. Fredericksen,Vernon S. Pankratz,Noralane M. Lindor,Csilla Szabo,Kenneth Offit,Rita A. Sakr,Mia M. Gaudet,Christian F. Singer,Muy Kheng Tea,Christine Rappaport,Phuong L. Mai,Mark H. Greene,Anna P. Sokolenko,Evgeny N. Imyanitov,Amanda E. Toland,Leigha Senter,Kevin Sweet,Mads Thomassen,Anne-Marie Gerdes,Torben A Kruse,Maria A. Caligo,Paolo Aretini,Johanna Rantala,Anna Von Wachenfeld,Karin M. Henriksson,Linda Steele,Susan L. Neuhausen,Robert L. Nussbaum,Mary S. Beattie,Kunle Odunsi,Lara Sucheston,Simon A. Gayther,Katherine L. Nathanson,Jenny Gross,Christine Walsh,Beth Y. Karlan,Georgia Chenevix-Trench,Douglas F. Easton,Antonis C. Antoniou +132 more
TL;DR: Pathologic characteristics of BRCA1 and BRCa2 tumors may be useful for improving risk-prediction algorithms and informing clinical strategies for screening and prophylaxis.
Journal ArticleDOI
Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk
Fergus J. Couch,Xianshu Wang,Lesley McGuffog,Andy C. H. Lee,Curtis Olswold,Karoline Kuchenbaecker,Penny Soucy,Zachary S. Fredericksen,Daniel Barrowdale,Joe Dennis,Mia M. Gaudet,Ed Dicks,Matthew L. Kosel,Sue Healey,Olga M. Sinilnikova,Adam M. Lee,Francois Bacot,Daniel Vincent,Frans B. L. Hogervorst,Susan Peock,Dominique Stoppa-Lyonnet,Anna Jakubowska,Paolo Radice,Rita K. Schmutzler,Susan M. Domchek,Marion Piedmonte,Christian F. Singer,Eitan Friedman,Mads Thomassen,Thomas Hansen,Susan L. Neuhausen,Csilla Szabo,Ignacio Blanco,Mark H. Greene,Beth Y. Karlan,Judy Garber,Catherine M. Phelan,Jeffrey N. Weitzel,Marco Montagna,Edith Olah,Irene L. Andrulis,Andrew K. Godwin,Drakoulis Yannoukakos,David E. Goldgar,Trinidad Caldés,Heli Nevanlinna,Ana Osorio,Mary Beth Terry,Mary B. Daly,Elizabeth J. van Rensburg,Ute Hamann,Susan J. Ramus,Amanda E. Toland,Maria A. Caligo,Olufunmilayo I. Olopade,Nadine Tung,Kathleen Claes,Mary S. Beattie,Melissa C. Southey,Evgeny N. Imyanitov,Marc Tischkowitz,Ramunas Janavicius,Esther M. John,Ava Kwong,Orland Diez,Judith Balmaña,Rosa B. Barkardottir,Banu Arun,Gad Rennert,Soo Hwang Teo,Patricia A. Ganz,Ian G. Campbell,Annemarie H. van der Hout,Carolien H.M. van Deurzen,Caroline Seynaeve,Encarna B. Gomez Garcia,Flora E. van Leeuwen,Hanne Meijers-Heijboer,Johannes J. P. Gille,Margreet G. E. M. Ausems,Marinus J. Blok,Marjolijn J. L. Ligtenberg,Matti A. Rookus,Peter Devilee,Senno Verhoef,Theo A. M. van Os,Juul T. Wijnen,Debra Frost,Steve Ellis,Elena Fineberg,Radka Platte,D. Gareth Evans,Louise Izatt,Rosalind A. Eeles,Julian Adlard,Diana Eccles,Jackie Cook,Carole Brewer,Fiona Douglas,Shirley Hodgson,Patrick J. Morrison,Lucy Side,Alan Donaldson,C. E. Houghton,Mark T. Rogers,Huw Dorkins,Jacqueline Eason,Helen Gregory,Emma McCann,Alex Murray,Alain Calender,Agnès Hardouin,Pascaline Berthet,Capucine Delnatte,Catherine Noguès,Christine Lasset,Claude Houdayer,Dominique Leroux,Etienne Rouleau,Fabienne Prieur,Francesca Damiola,Hagay Sobol,Isabelle Coupier,Laurence Venat-Bouvet,Laurent Castera,Marion Gauthier-Villars,Mélanie Léoné,Pascal Pujol,Sylvie Mazoyer,Yves-Jean Bignon,Elżbieta Złowocka-Perłowska,Jacek Gronwald,Jan Lubinski,Katarzyna Durda,Katarzyna Jaworska,Tomasz Huzarski,Amanda B. Spurdle,Alessandra Viel,Bernard Peissel,Bernardo Bonanni,Giulia Melloni,Laura Ottini,Laura Papi,Liliana Varesco,Maria Grazia Tibiletti,Paolo Peterlongo,Sara Volorio,Siranoush Manoukian,Valeria Pensotti,Norbert Arnold,Christoph Engel,Helmut Deissler,Dorothea Gadzicki,Andrea Gehrig,Karin Kast,Kerstin Rhiem,Alfons Meindl,Dieter Niederacher,Nina Ditsch,Hansjoerg Plendl,Sabine Preisler-Adams,Stefanie Engert,Christian Sutter,Raymonda Varon-Mateeva,Barbara Wappenschmidt,Bernhard H. F. Weber,Brita Arver,Marie Stenmark-Askmalm,Niklas Loman,Richard Rosenquist,Zakaria Einbeigi,Katherine L. Nathanson,Timothy R. Rebbeck,Stephanie V. Blank,David E. Cohn,Gustavo C. Rodriguez,Laurie Small,Michael Friedlander,Victoria L. Bae-Jump,Anneliese Fink-Retter,Christine Rappaport,Daphne Gschwantler-Kaulich,Georg Pfeiler,Muy-Kheng Tea,Noralane M. Lindor,Bella Kaufman,Shani Shimon Paluch,Yael Laitman,Anne-Bine Skytte,Anne-Marie Gerdes,Inge Søkilde Pedersen,Sanne Traasdahl Moeller,Torben A Kruse,Uffe Birk Jensen,Joseph Vijai,Kara Sarrel,Mark E. Robson,Noah D. Kauff,Anna Marie Mulligan,Gord Glendon,Hilmi Ozcelik,Bent Ejlertsen,Finn Cilius Nielsen,Lars Jønson,Mette K. Andersen,Yuan Chun Ding,Linda Steele,Lenka Foretova,Alex Teulé,Conxi Lázaro,Joan Brunet,Miquel Angel Pujana,Phuong L. Mai,Jennifer T. Loud,Christine Walsh,Jenny Lester,Sandra Orsulic,Steven A. Narod,Josef Herzog,Sharon Sand,Silvia Tognazzo,Simona Agata,Tibor Vaszko,JoEllen Weaver,Alexandra V. Stavropoulou,Saundra S. Buys,Atocha Romero,Miguel de la Hoya,Kristiina Aittomäki,Taru A. Muranen,Mercedes Durán,Wendy K. Chung,Adriana Lasa,Cecilia M. Dorfling,Alexander Miron,Javier Benitez,Leigha Senter,Dezheng Huo,Salina B. Chan,Anna P. Sokolenko,Jocelyne Chiquette,Laima Tihomirova,Tara M. Friebel,Bjarni A. Agnarsson,Karen H. Lu,Flavio Lejbkowicz,Paul A. James,Per Hall,Alison M. Dunning,Daniel C. Tessier,Julie M. Cunningham,Susan L. Slager,Chen Wang,Steven N. Hart,Kristen N. Stevens,Jacques Simard,Tomi Pastinen,Vernon S. Pankratz,Kenneth Offit,Douglas F. Easton,Georgia Chenevix-Trench,Antonis C. Antoniou +261 more
TL;DR: It is estimated that the breast cancer lifetime risks for the5% of BRCA1 carriers at lowest risk are 28%–50% compared to 81%–100% for the 5% at highest risk, and the ovarian cancer lifetime risk is 63% or higher, based on the known cancer risk-modifying loci.
Journal ArticleDOI
Association of type and location of BRCA1 and BRCA2 mutations with risk of breast and ovarian cancer.
Timothy R. Rebbeck,Nandita Mitra,Fei Wan,Olga M. Sinilnikova,Sue Healey,Lesley McGuffog,Sylvie Mazoyer,Georgia Chenevix-Trench,Douglas F. Easton,Antonis C. Antoniou,Katherine L. Nathanson,Yael Laitman,Anya Kushnir,Shani Paluch-Shimon,Raanan Berger,Jamal Zidan,Eitan Friedman,Hans Ehrencrona,Hans Ehrencrona,Marie Stenmark-Askmalm,Zakaria Einbeigi,Niklas Loman,Katja Harbst,Johanna Rantala,Beatrice Melin,Dezheng Huo,Olufunmilayo I. Olopade,Joyce Seldon,Patricia A. Ganz,Robert L. Nussbaum,Salina B. Chan,Kunle Odunsi,Simon A. Gayther,Susan M. Domchek,Banu Arun,Karen H. Lu,Gillian Mitchell,Gillian Mitchell,Beth Y. Karlan,Christine Walsh,Jenny Lester,Andrew K. Godwin,Harsh B. Pathak,Eric A. Ross,Mary B. Daly,Alice S. Whittemore,Esther M. John,Alexander Miron,Mary Beth Terry,Wendy K. Chung,David E. Goldgar,Saundra S. Buys,Ramūnas Janavičius,Laima Tihomirova,Nadine Tung,Cecilia M. Dorfling,Elizabeth J. van Rensburg,Linda Steele,Susan L. Neuhausen,Yuan Chun Ding,Bent Ejlertsen,Anne-Marie Gerdes,Thomas Hansen,Teresa Ramón y Cajal,Ana Osorio,Javier Benitez,Javier Godino,Maria-Isabel Tejada,Mercedes Durán,Jeffrey N. Weitzel,Kristie Bobolis,Sharon Sand,Annette Fontaine,Antonella Savarese,Barbara Pasini,Bernard Peissel,Bernardo Bonanni,Daniela Zaffaroni,Francesca Vignolo-Lutati,Giulietta Scuvera,Giuseppe Giannini,Loris Bernard,Maurizio Genuardi,Paolo Radice,Riccardo Dolcetti,Siranoush Manoukian,Valeria Pensotti,Viviana Gismondi,Drakoulis Yannoukakos,Florentia Fostira,Judy Garber,Diana Torres,Muhammad Usman Rashid,Ute Hamann,Susan Peock,Debra Frost,Radka Platte,D. Gareth Evans,Rosalind A. Eeles,Rosemarie Davidson,Diana Eccles,Trevor Cole,Jackie Cook,Carole Brewer,Shirley Hodgson,Patrick J. Morrison,Lisa Walker,Mary Porteous,M. John Kennedy,Louise Izatt,Julian Adlard,Alan Donaldson,Steve Ellis,Priyanka Sharma,Rita K. Schmutzler,Barbara Wappenschmidt,Alexandra Becker,Kerstin Rhiem,Eric Hahnen,Christoph Engel,Alfons Meindl,Stefanie Engert,Nina Ditsch,Norbert Arnold,Hans Jörg Plendl,Christoph Mundhenke,Dieter Niederacher,Markus C. Fleisch,Christian Sutter,Claus R. Bartram,Nicola Dikow,Shan Wang-Gohrke,Dorothea Gadzicki,Doris Steinemann,Karin Kast,Marit Beer,Raymonda Varon-Mateeva,Andrea Gehrig,Bernhard H. F. Weber,Dominique Stoppa-Lyonnet,Dominique Stoppa-Lyonnet,Claude Houdayer,Claude Houdayer,Muriel Belotti,Marion Gauthier-Villars,Francesca Damiola,Nadia Boutry-Kryza,Christine Lasset,Hagay Sobol,Jean-Philippe Peyrat,Danièle Muller,Jean-Pierre Fricker,Marie-Agnès Collonge-Rame,Isabelle Mortemousque,Catherine Noguès,Etienne Rouleau,Claudine Isaacs,Anne De Paepe,Bruce Poppe,Kathleen Claes,Kim De Leeneer,Marion Piedmonte,Gustavo C. Rodriguez,Katie Wakely,John F. Boggess,Stephanie V. Blank,Jack Basil,Masoud Azodi,Kelly-Anne Phillips,Kelly-Anne Phillips,Trinidad Caldés,Miguel de la Hoya,Atocha Romero,Heli Nevanlinna,Kristiina Aittomäki,Annemarie H. van der Hout,Frans B. L. Hogervorst,Senno Verhoef,J. Margriet Collée,Caroline Seynaeve,Jan C. Oosterwijk,Johannes J. P. Gille,Juul T. Wijnen,Encarna B. Gomez Garcia,Carolien M. Kets,Margreet G. E. M. Ausems,Cora M. Aalfs,Peter Devilee,Arjen R. Mensenkamp,Ava Kwong,Edith Olah,János Papp,Orland Diez,Conxi Lázaro,Esther Darder,Ignacio Blanco,Mónica Salinas,Anna Jakubowska,Jan Lubinski,Jacek Gronwald,Katarzyna Jaworska-Bieniek,Katarzyna Durda,Grzegorz Sukiennicki,Tomasz Huzarski,Tomasz Byrski,Cezary Cybulski,Aleksandra Tołoczko-Grabarek,Elżbieta Złowocka-Perłowska,Janusz Menkiszak,Adalgeir Arason,Rosa B. Barkardottir,Jacques Simard,Rachel Laframboise,Marco Montagna,Simona Agata,Elisa Alducci,Ana Peixoto,Manuel R. Teixeira,Amanda B. Spurdle,Min Hyuk Lee,Sue K. Park,Sung-Won Kim,Tara M. Friebel,Fergus J. Couch,Noralane M. Lindor,Vernon S. Pankratz,Lucia Guidugli,Xianshu Wang,Marc Tischkowitz,Marc Tischkowitz,Lenka Foretova,Joseph Vijai,Kenneth Offit,Mark E. Robson,Rohini Rau-Murthy,Noah D. Kauff,Anneliese Fink-Retter,Christian F. Singer,Christine Rappaport,Daphne Gschwantler-Kaulich,Georg Pfeiler,Muy-Kheng Tea,Andreas Berger,Mark H. Greene,Phuong L. Mai,Evgeny N. Imyanitov,Amanda E. Toland,Leigha Senter,Anders Bojesen,Inge Søkilde Pedersen,Anne-Bine Skytte,Lone Sunde,Mads Thomassen,Sanne Traasdahl Moeller,Torben A Kruse,Uffe Birk Jensen,Maria A. Caligo,Paolo Aretini,Soo Hwang Teo,Christina G. Selkirk,Peter J. Hulick,Irene L. Andrulis +261 more
TL;DR: In this paper, the relationship between specific mutations in BRCA1 and cancer risk has been investigated and limited information about the relationship has been available about specific mutations for specific mutations.