N
Nicole Sprugasci
Researcher at University of Washington
Publications - 13
Citations - 2326
Nicole Sprugasci is an academic researcher from University of Washington. The author has contributed to research in topics: Epitope & Antibody. The author has an hindex of 9, co-authored 9 publications receiving 881 citations. Previous affiliations of Nicole Sprugasci include Rega Institute for Medical Research.
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Journal ArticleDOI
Mapping Neutralizing and Immunodominant Sites on the SARS-CoV-2 Spike Receptor-Binding Domain by Structure-Guided High-Resolution Serology.
Luca Piccoli,Young-Jun Park,M. Alejandra Tortorici,M. Alejandra Tortorici,Nadine Czudnochowski,Alexandra C. Walls,Martina Beltramello,Chiara Silacci-Fregni,Dora Pinto,Laura E. Rosen,John E. Bowen,Oliver J. Acton,Stefano Jaconi,Barbara Guarino,Andrea Minola,Fabrizia Zatta,Nicole Sprugasci,Jessica Bassi,Alessia Peter,Anna De Marco,Jay C. Nix,Federico Mele,Sandra Jovic,Blanca Fernandez Rodriguez,Sneha V. Gupta,Feng Jin,Giovanni Piumatti,Giovanni Piumatti,Giorgia Lo Presti,Alessandra Franzetti Pellanda,Maira Biggiogero,Maciej Tarkowski,Matteo Samuele Pizzuto,Elisabetta Cameroni,Colin Havenar-Daughton,Megan Smithey,David K. Hong,Valentino Lepori,Emiliano Albanese,Alessandro Ceschi,Alessandro Ceschi,Enos Bernasconi,Luigia Elzi,Paolo Ferrari,Christian Garzoni,Agostino Riva,G. Snell,Federica Sallusto,Katja Fink,Herbert W. Virgin,Antonio Lanzavecchia,Davide Corti,David Veesler +52 more
TL;DR: It is found that both the magnitude of Ab responses to SARS-CoV-2 spike (S) and nucleoprotein and nAb titers correlate with clinical scores, and the immunodominance of the receptor-binding motif will guide the design of COVID-19 vaccines and therapeutics.
Journal ArticleDOI
Ultrapotent human antibodies protect against SARS-CoV-2 challenge via multiple mechanisms
M. Alejandra Tortorici,M. Alejandra Tortorici,Martina Beltramello,Florian A. Lempp,Dora Pinto,Ha V. Dang,Laura E. Rosen,Matthew McCallum,John E. Bowen,Andrea Minola,Stefano Jaconi,Fabrizia Zatta,Anna De Marco,Barbara Guarino,Siro Bianchi,Elvin J. Lauron,Heather Tucker,Jiayi Zhou,Alessia Peter,Colin Havenar-Daughton,Jason A. Wojcechowskyj,James Brett Case,Rita E. Chen,Hannah Kaiser,Martin Montiel-Ruiz,Marcel Meury,Nadine Czudnochowski,Roberto Spreafico,Josh Dillen,Cindy Ng,Nicole Sprugasci,Katja Culap,Fabio Benigni,Rana Abdelnabi,Shi Yan Caroline Foo,Michael A. Schmid,Elisabetta Cameroni,Agostino Riva,Arianna Gabrieli,Massimo Galli,Matteo Samuele Pizzuto,Johan Neyts,Michael S. Diamond,Herbert W. Virgin,Herbert W. Virgin,G. Snell,Davide Corti,Katja Fink,David Veesler +48 more
TL;DR: The isolation and characterization of two ultrapotent Sars-CoV-2 human neutralizing antibodies (S2E12 and S2M11) that protect hamsters against SARS-Cov-2 challenge and pave the way to implement antibody cocktails for prophylaxis or therapy, circumventing or limiting the emergence of viral escape mutants.
Journal ArticleDOI
SARS-CoV-2 RBD antibodies that maximize breadth and resistance to escape.
Tyler N. Starr,Nadine Czudnochowski,Zhuoming Liu,Fabrizia Zatta,Young-Jun Park,Amin Addetia,Dora Pinto,Martina Beltramello,Patrick Hernandez,Allison J. Greaney,Allison J. Greaney,Roberta Marzi,William G. Glass,Ivy Zhang,Ivy Zhang,Adam S. Dingens,John E. Bowen,M. Alejandra Tortorici,Alexandra C. Walls,Jason A. Wojcechowskyj,Anna De Marco,Laura E. Rosen,Jiayi Zhou,Martin Montiel-Ruiz,Hannah Kaiser,Josh Dillen,Heather Tucker,Jessica Bassi,Chiara Silacci-Fregni,Michael P. Housley,Julia di Iulio,Gloria Lombardo,Maria L. Agostini,Nicole Sprugasci,Katja Culap,Stefano Jaconi,Marcel Meury,Exequiel Dellota,Rana Abdelnabi,Shi-Yan Caroline Foo,Elisabetta Cameroni,Spencer Stumpf,Tristan I. Croll,Jay C. Nix,Colin Havenar-Daughton,Luca Piccoli,Fabio Benigni,Johan Neyts,Amalio Telenti,Florian A. Lempp,Matteo Samuele Pizzuto,John D. Chodera,Christy M. Hebner,Herbert W. Virgin,Herbert W. Virgin,Sean P. J. Whelan,David Veesler,Davide Corti,Jesse D. Bloom,Jesse D. Bloom,Jesse D. Bloom,Gyorgy Snell +61 more
TL;DR: In this paper, the authors comprehensively characterize escape, breadth and potency across a panel of SARS-CoV-2 antibodies targeting the receptor-binding domain (RBD).
Journal ArticleDOI
Broad betacoronavirus neutralization by a stem helix-specific human antibody.
Dora Pinto,Dora Pinto,Maximilian M. Sauer,Nadine Czudnochowski,Jun Siong Low,Jun Siong Low,M. Alejandra Tortorici,Michael P. Housley,Julia Noack,Alexandra C. Walls,John E. Bowen,Barbara Guarino,Barbara Guarino,Laura E. Rosen,Julia di Iulio,Josipa Jerak,Josipa Jerak,Josipa Jerak,Hannah Kaiser,Saiful Islam,Stefano Jaconi,Stefano Jaconi,Nicole Sprugasci,Nicole Sprugasci,Katja Culap,Katja Culap,Rana Abdelnabi,Caroline S. Foo,Lotte Coelmont,Istvan Bartha,Istvan Bartha,Siro Bianchi,Siro Bianchi,Chiara Silacci-Fregni,Chiara Silacci-Fregni,Jessica Bassi,Roberta Marzi,Roberta Marzi,Eneida Vetti,Eneida Vetti,Antonino Cassotta,Antonino Cassotta,Alessandro Ceschi,Paolo Ferrari,Pietro E. Cippà,Olivier Giannini,Samuele Ceruti,Christian Garzoni,Agostino Riva,Fabio Benigni,Fabio Benigni,Elisabetta Cameroni,Elisabetta Cameroni,Luca Piccoli,Luca Piccoli,Matteo Samuele Pizzuto,Matteo Samuele Pizzuto,Megan Smithey,David I. Hong,Amalio Telenti,Florian A. Lempp,Johan Neyts,Colin Havenar-Daughton,Antonio Lanzavecchia,Antonio Lanzavecchia,Federica Sallusto,Federica Sallusto,Gyorgy Snell,Herbert W. Virgin,Martina Beltramello,Davide Corti,David Veesler +71 more
TL;DR: In this article, the authors describe five monoclonal antibodies cross-reacting with the stem helix of multiple β-coronavirus spike glycoproteins isolated from COVID-19 convalescent individuals.
Journal ArticleDOI
Broad sarbecovirus neutralization by a human monoclonal antibody.
M. Alejandra Tortorici,M. Alejandra Tortorici,Nadine Czudnochowski,Tyler N. Starr,Roberta Marzi,Alexandra C. Walls,Fabrizia Zatta,John E. Bowen,Stefano Jaconi,Julia di Iulio,Z. Wang,Anna De Marco,Samantha K Zepeda,Dora Pinto,Zhuoming Liu,Martina Beltramello,Istvan Bartha,Michael P. Housley,Florian A. Lempp,Laura E. Rosen,Exequiel Dellota,Hannah Kaiser,Martin Montiel-Ruiz,Jiayi Zhou,Amin Addetia,Barbara Guarino,Katja Culap,Nicole Sprugasci,Christian Saliba,Eneida Vetti,Isabella Giacchetto-Sasselli,Chiara Silacci Fregni,Rana Abdelnabi,Shi Yan Caroline Foo,Colin Havenar-Daughton,Michael A. Schmid,Fabio Benigni,Elisabetta Cameroni,Johan Neyts,Amalio Telenti,Herbert W. Virgin,Sean P. J. Whelan,Gyorgy Snell,Jesse D. Bloom,Jesse D. Bloom,Davide Corti,David Veesler,Matteo Samuele Pizzuto +47 more
TL;DR: S2X259 as discussed by the authors is a human monoclonal antibody that recognizes a highly conserved cryptic epitope of the receptor-binding domain and cross-reacts with spikes from all clades of sarbecovirus.