F
Fabio Benigni
Researcher at University of Washington
Publications - 15
Citations - 2251
Fabio Benigni is an academic researcher from University of Washington. The author has contributed to research in topics: Epitope & Antibody. The author has an hindex of 11, co-authored 15 publications receiving 711 citations. Previous affiliations of Fabio Benigni include Rega Institute for Medical Research.
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Journal ArticleDOI
N-terminal domain antigenic mapping reveals a site of vulnerability for SARS-CoV-2.
Matthew McCallum,Anna De Marco,Florian A. Lempp,M. Alejandra Tortorici,M. Alejandra Tortorici,Dora Pinto,Alexandra C. Walls,Martina Beltramello,Alexander Chen,Zhuoming Liu,Fabrizia Zatta,Samantha K Zepeda,Julia di Iulio,John E. Bowen,Martin Montiel-Ruiz,Jiayi Zhou,Laura E. Rosen,Siro Bianchi,Barbara Guarino,Chiara Silacci Fregni,Rana Abdelnabi,Shi Yan Caroline Foo,Paul W. Rothlauf,Louis Marie Bloyet,Fabio Benigni,Elisabetta Cameroni,Johan Neyts,Agostino Riva,Gyorgy Snell,Amalio Telenti,Sean P. J. Whelan,Herbert W. Virgin,Davide Corti,Matteo Samuele Pizzuto,David Veesler +34 more
TL;DR: In this article, 41 human monoclonal antibodies derived from memory B cells were used to identify the SARS-CoV-2 S N-terminal domain (NTD).
Journal ArticleDOI
Ultrapotent human antibodies protect against SARS-CoV-2 challenge via multiple mechanisms
M. Alejandra Tortorici,M. Alejandra Tortorici,Martina Beltramello,Florian A. Lempp,Dora Pinto,Ha V. Dang,Laura E. Rosen,Matthew McCallum,John E. Bowen,Andrea Minola,Stefano Jaconi,Fabrizia Zatta,Anna De Marco,Barbara Guarino,Siro Bianchi,Elvin J. Lauron,Heather Tucker,Jiayi Zhou,Alessia Peter,Colin Havenar-Daughton,Jason A. Wojcechowskyj,James Brett Case,Rita E. Chen,Hannah Kaiser,Martin Montiel-Ruiz,Marcel Meury,Nadine Czudnochowski,Roberto Spreafico,Josh Dillen,Cindy Ng,Nicole Sprugasci,Katja Culap,Fabio Benigni,Rana Abdelnabi,Shi Yan Caroline Foo,Michael A. Schmid,Elisabetta Cameroni,Agostino Riva,Arianna Gabrieli,Massimo Galli,Matteo Samuele Pizzuto,Johan Neyts,Michael S. Diamond,Herbert W. Virgin,Herbert W. Virgin,G. Snell,Davide Corti,Katja Fink,David Veesler +48 more
TL;DR: The isolation and characterization of two ultrapotent Sars-CoV-2 human neutralizing antibodies (S2E12 and S2M11) that protect hamsters against SARS-Cov-2 challenge and pave the way to implement antibody cocktails for prophylaxis or therapy, circumventing or limiting the emergence of viral escape mutants.
Journal ArticleDOI
SARS-CoV-2 RBD antibodies that maximize breadth and resistance to escape.
Tyler N. Starr,Nadine Czudnochowski,Zhuoming Liu,Fabrizia Zatta,Young-Jun Park,Amin Addetia,Dora Pinto,Martina Beltramello,Patrick Hernandez,Allison J. Greaney,Allison J. Greaney,Roberta Marzi,William G. Glass,Ivy Zhang,Ivy Zhang,Adam S. Dingens,John E. Bowen,M. Alejandra Tortorici,Alexandra C. Walls,Jason A. Wojcechowskyj,Anna De Marco,Laura E. Rosen,Jiayi Zhou,Martin Montiel-Ruiz,Hannah Kaiser,Josh Dillen,Heather Tucker,Jessica Bassi,Chiara Silacci-Fregni,Michael P. Housley,Julia di Iulio,Gloria Lombardo,Maria L. Agostini,Nicole Sprugasci,Katja Culap,Stefano Jaconi,Marcel Meury,Exequiel Dellota,Rana Abdelnabi,Shi-Yan Caroline Foo,Elisabetta Cameroni,Spencer Stumpf,Tristan I. Croll,Jay C. Nix,Colin Havenar-Daughton,Luca Piccoli,Fabio Benigni,Johan Neyts,Amalio Telenti,Florian A. Lempp,Matteo Samuele Pizzuto,John D. Chodera,Christy M. Hebner,Herbert W. Virgin,Herbert W. Virgin,Sean P. J. Whelan,David Veesler,Davide Corti,Jesse D. Bloom,Jesse D. Bloom,Jesse D. Bloom,Gyorgy Snell +61 more
TL;DR: In this paper, the authors comprehensively characterize escape, breadth and potency across a panel of SARS-CoV-2 antibodies targeting the receptor-binding domain (RBD).
Journal ArticleDOI
Broad betacoronavirus neutralization by a stem helix-specific human antibody.
Dora Pinto,Dora Pinto,Maximilian M. Sauer,Nadine Czudnochowski,Jun Siong Low,Jun Siong Low,M. Alejandra Tortorici,Michael P. Housley,Julia Noack,Alexandra C. Walls,John E. Bowen,Barbara Guarino,Barbara Guarino,Laura E. Rosen,Julia di Iulio,Josipa Jerak,Josipa Jerak,Josipa Jerak,Hannah Kaiser,Saiful Islam,Stefano Jaconi,Stefano Jaconi,Nicole Sprugasci,Nicole Sprugasci,Katja Culap,Katja Culap,Rana Abdelnabi,Caroline S. Foo,Lotte Coelmont,Istvan Bartha,Istvan Bartha,Siro Bianchi,Siro Bianchi,Chiara Silacci-Fregni,Chiara Silacci-Fregni,Jessica Bassi,Roberta Marzi,Roberta Marzi,Eneida Vetti,Eneida Vetti,Antonino Cassotta,Antonino Cassotta,Alessandro Ceschi,Paolo Ferrari,Pietro E. Cippà,Olivier Giannini,Samuele Ceruti,Christian Garzoni,Agostino Riva,Fabio Benigni,Fabio Benigni,Elisabetta Cameroni,Elisabetta Cameroni,Luca Piccoli,Luca Piccoli,Matteo Samuele Pizzuto,Matteo Samuele Pizzuto,Megan Smithey,David I. Hong,Amalio Telenti,Florian A. Lempp,Johan Neyts,Colin Havenar-Daughton,Antonio Lanzavecchia,Antonio Lanzavecchia,Federica Sallusto,Federica Sallusto,Gyorgy Snell,Herbert W. Virgin,Martina Beltramello,Davide Corti,David Veesler +71 more
TL;DR: In this article, the authors describe five monoclonal antibodies cross-reacting with the stem helix of multiple β-coronavirus spike glycoproteins isolated from COVID-19 convalescent individuals.
Journal ArticleDOI
Lectins enhance SARS-CoV-2 infection and influence neutralizing antibodies.
Florian A. Lempp,Leah Soriaga,Martin Montiel-Ruiz,Fabio Benigni,Julia Noack,Young-Jun Park,Siro Bianchi,Alexandra C. Walls,John E. Bowen,Jiayi Zhou,Hannah Kaiser,Anshu Joshi,Maria De Agostini,Marcel Meury,Exequiel Dellota,Stefano Jaconi,Elisabetta Cameroni,Javier Martinez-Picado,Javier Martinez-Picado,Júlia Vergara-Alert,Nuria Izquierdo-Useros,Herbert W. Virgin,Herbert W. Virgin,Antonio Lanzavecchia,David Veesler,Lisa A. Purcell,Amalio Telenti,Davide Corti +27 more
TL;DR: In this article, C-type lectins and SIGLEC1 function as attachment-receptors for SARS-CoV-2 infection and reveal distinct mechanisms of neutralization by different classes of spike-specific antibodies.