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Spencer Stumpf
Researcher at Washington University in St. Louis
Publications - 13
Citations - 1364
Spencer Stumpf is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 6, co-authored 9 publications receiving 484 citations. Previous affiliations of Spencer Stumpf include University of Georgia.
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Journal ArticleDOI
Identification of SARS-CoV-2 spike mutations that attenuate monoclonal and serum antibody neutralization.
Zhuoming Liu,Laura A. VanBlargan,Louis Marie Bloyet,Paul W. Rothlauf,Paul W. Rothlauf,Rita E. Chen,Spencer Stumpf,Haiyan Zhao,John M. Errico,Elitza S. Theel,Mariel J. Liebeskind,Brynn Alford,William Buchser,Ali H. Ellebedy,Daved H. Fremont,Michael S. Diamond,Sean P. J. Whelan +16 more
TL;DR: In this article, a VSV-eGFP-SARS-CoV-2-S chimeric virus was exposed to 19 neutralizing monoclonal antibodies (mAbs) against the receptor-binding domain (RBD) and generated 50 different escape mutants.
Journal ArticleDOI
SARS-CoV-2 RBD antibodies that maximize breadth and resistance to escape.
Tyler N. Starr,Nadine Czudnochowski,Zhuoming Liu,Fabrizia Zatta,Young-Jun Park,Amin Addetia,Dora Pinto,Martina Beltramello,Patrick Hernandez,Allison J. Greaney,Allison J. Greaney,Roberta Marzi,William G. Glass,Ivy Zhang,Ivy Zhang,Adam S. Dingens,John E. Bowen,M. Alejandra Tortorici,Alexandra C. Walls,Jason A. Wojcechowskyj,Anna De Marco,Laura E. Rosen,Jiayi Zhou,Martin Montiel-Ruiz,Hannah Kaiser,Josh Dillen,Heather Tucker,Jessica Bassi,Chiara Silacci-Fregni,Michael P. Housley,Julia di Iulio,Gloria Lombardo,Maria L. Agostini,Nicole Sprugasci,Katja Culap,Stefano Jaconi,Marcel Meury,Exequiel Dellota,Rana Abdelnabi,Shi-Yan Caroline Foo,Elisabetta Cameroni,Spencer Stumpf,Tristan I. Croll,Jay C. Nix,Colin Havenar-Daughton,Luca Piccoli,Fabio Benigni,Johan Neyts,Amalio Telenti,Florian A. Lempp,Matteo Samuele Pizzuto,John D. Chodera,Christy M. Hebner,Herbert W. Virgin,Herbert W. Virgin,Sean P. J. Whelan,David Veesler,Davide Corti,Jesse D. Bloom,Jesse D. Bloom,Jesse D. Bloom,Gyorgy Snell +61 more
TL;DR: In this paper, the authors comprehensively characterize escape, breadth and potency across a panel of SARS-CoV-2 antibodies targeting the receptor-binding domain (RBD).
Journal ArticleDOI
In vivo monoclonal antibody efficacy against SARS-CoV-2 variant strains.
Rita E. Chen,Emma S. Winkler,James Brett Case,Ishmael D. Aziati,Traci L. Bricker,Astha Joshi,Tamarand L. Darling,Baoling Ying,John M. Errico,Swathi Shrihari,Laura A. VanBlargan,Xuping Xie,Pavlo Gilchuk,Seth J. Zost,Lindsay Droit,Zhuoming Liu,Spencer Stumpf,David Wang,Scott A. Handley,W. Blaine Stine,Pei Yong Shi,Meredith E. Davis-Gardner,Mehul S. Suthar,Miguel Garcia Knight,Raul Andino,Charles Y. Chiu,Ali H. Ellebedy,Daved H. Fremont,Sean P. J. Whelan,James E. Crowe,Lisa A. Purcell,Davide Corti,Adrianus C. M. Boon,Michael S. Diamond +33 more
TL;DR: In this paper, the authors report the in vitro and in vivo activity of a panel of monoclonal antibodies (mAbs) against SARS-CoV-2 variant viruses, which correspond to many mAb combinations in advanced clinical development by Vir Biotechnology, AbbVie, AstraZeneca, Regeneron and Lilly.
Journal ArticleDOI
Defining the risk of SARS-CoV-2 variants on immune protection
Marciela M. DeGrace,Elodie Ghedin,Matthew B. Frieman,Florian Krammer,Alba Grifoni,Arghavan Alisoltani,Galit Alter,Rama Rao Amara,Ralph S. Baric,Dan H. Barouch,Jesse D. Bloom,Louis-Marie Bloyet,Gaston Bonenfant,Adrianus C. M. Boon,Eli Boritz,Debbie L Bratt,Traci L. Bricker,Liliana L Brown,William Buchser,Juan Manuel Carreño,Liel Cohen-Lavi,Tamarand L. Darling,Meredith E. Davis-Gardner,Bethany L. Dearlove,Han Di,Meike Dittmann,Nicole A. Doria-Rose,Daniel C. Douek,Christian Drosten,Venkata Viswanadh Edara,Ali H. Ellebedy,Thomas P. Fabrizio,Guido Ferrari,William C. Florence,Ron A. M. Fouchier,John Franks,Adolfo García-Sastre,Adam Godzik,Ana S. Gonzalez-Reiche,Aubree Gordon,Bart L. Haagmans,Peter Halfmann,David D. Ho,Michael R. Holbrook,Yaoxing Huang,Sarah James,Lukasz Jaroszewski,Trushar Jeevan,Robert M. Johnson,Terry Jones,Astha Joshi,Yoshihiro Kawaoka,Lisa Kercher,Marion Koopmans,Bette T. Korber,Eilay Koren,Richard A. Koup,Eric B. LeGresley,Jacob E. Lemieux,Mariel J. Liebeskind,Zhuoming Li,Brandi Livingston,James Logue,Yang Luo,Adrian B. McDermott,M. Juliana McElrath,Victoria A. Meliopoulos,Vineet D. Menachery,David C. Montefiori,Barbara Mühlemann,Vincent J. Munster,Jennifer E. Munt,Manoj S. Nair,Antonia Netzl,Anna Maria Niewiadomska,Sijy O'Dell,Andrew Pekosz,Stanley Perlman,Marjorie Cornejo Pontelli,Barry Rockx,Morgane Rolland,Paul W. Rothlauf,Sinai Sacharen,Richard H. Scheuermann,R. Schmidt,Michael Schotsaert,Stacey Schultz-Cherry,Robert A. Seder,Mayya Sedova,Alessandro Sette,Reed S. Shabman,Xiaoying Shen,Pei Yong Shi,Maulik Shukla,Viviana Simon,Spencer Stumpf,Nancy J. Sullivan,Larissa B. Thackray,James Theiler,Paul G. Thomas,Sanja Trifkovic,Sina Türeli,Samuel Ashby Turner,Maria Vakaki,Harm van Bakel,Laura A. VanBlargan,Leah R. Vincent,Zachary S. Wallace,Liang Wang,Maple Wang,Pengfei Wang,Wei Wang,Scott C. Weaver,Richard J. Webby,Carol D. Weiss,David E. Wentworth,Stuart Weston,Sean P. J. Whelan,Bradley M. Whitener,S. H. Wilks,Xuping Xie,Baoling Ying,Hyejin Yoon,Bin Zhou,Tomer Hertz,Derek J. Smith,Michael S. Diamond,Diane J. Post,Mehul S. Suthar +128 more
TL;DR: The SARS-CoV-2 Assessment of Viral Evolution (SAVE) as mentioned in this paper was designed to provide a real-time risk assessment of SARS CoV2 variants that could potentially affect the transmission, virulence and resistance to infection-and vaccine-induced immunity.
Journal ArticleDOI
Landscape Analysis of Escape Variants Identifies SARS-CoV-2 Spike Mutations that Attenuate Monoclonal and Serum Antibody Neutralization
Zhuoming Liu,Laura A. VanBlargan,Paul W. Rothlauf,Louis Marie Bloyet,Rita E. Chen,Spencer Stumpf,Haiyan Zhao,John M. Errico,Elitza S. Theel,Ali H. Ellebedy,Daved H. Fremont,Michael S. Diamond,Sean P. J. Whelan +12 more
TL;DR: By comparing the antibody-mediated mutational landscape in S protein with sequence variation in circulating SARS-CoV-2 strains, single amino acid substitutions that could attenuate neutralizing immune responses in some humans are identified.