Y
Yu Matsumoto
Researcher at University of Tokyo
Publications - 102
Citations - 6778
Yu Matsumoto is an academic researcher from University of Tokyo. The author has contributed to research in topics: Medicine & Nanocarriers. The author has an hindex of 37, co-authored 85 publications receiving 5732 citations. Previous affiliations of Yu Matsumoto include Memorial Hospital of South Bend & National Institute for Materials Science.
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Journal ArticleDOI
Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size
Horacio Cabral,Yu Matsumoto,Kazue Mizuno,Qixian Chen,Mami Murakami,M. Kimura,Yasuko Terada,Mitsunobu R. Kano,Kohei Miyazono,Mitsuru Uesaka,Nobuhiro Nishiyama,Kazunori Kataoka +11 more
TL;DR: It is shown that the penetration and efficacy of the larger micelles could be enhanced by using a transforming growth factor-β inhibitor to increase the permeability of the tumours.
Journal ArticleDOI
Cyclic RGD-linked polymeric micelles for targeted delivery of platinum anticancer drugs to glioblastoma through the blood-brain tumor barrier
Yutaka Miura,Tomoya Takenaka,Kazuko Toh,Shourong Wu,Hiroshi Nishihara,Mitsunobu R. Kano,Yasushi Ino,Takahiro Nomoto,Yu Matsumoto,Hiroyuki Koyama,Horacio Cabral,Nobuhiro Nishiyama,Kazunori Kataoka +12 more
TL;DR: It is likely that the selective and accelerated accumulation of cRGD/m into tumors occurred via an active internalization pathway, possibly transcytosis, thereby producing significant antitumor effects in an orthotopic mouse model of U87MG human glioblastoma.
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Vascular bursts enhance permeability of tumour blood vessels and improve nanoparticle delivery.
Yu Matsumoto,Joseph W. Nichols,Kazuko Toh,Takahiro Nomoto,Horacio Cabral,Yutaka Miura,R. James Christie,Naoki Yamada,Tadayoshi Ogura,Mitsunobu R. Kano,Yasuhiro Matsumura,Nobuhiro Nishiyama,Tatsuya Yamasoba,You Han Bae,Kazunori Kataoka +14 more
TL;DR: It is proposed that 'dynamic vents' form transient openings and closings at these leaky blood vessels that may explain the enhanced extravasation of nanoparticles from the tumour blood vessels, and offer insights into the underlying distribution patterns of an administered drug.
Journal ArticleDOI
Improving Drug Potency and Efficacy by Nanocarrier-Mediated Subcellular Targeting
Mami Murakami,Horacio Cabral,Yu Matsumoto,Shourong Wu,Mitsunobu R. Kano,Takao Yamori,Nobuhiro Nishiyama,Kazunori Kataoka +7 more
TL;DR: Tumors that have become resistant to DACHPt grow well in the presence of the drug, but the micelle-delivered version effectively inhibited the tumors’ growth, most likely by bypassing the cells’ cytoplasmic defenses.
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Therapeutic Vesicular Nanoreactors with Tumor‐Specific Activation and Self‐Destruction for Synergistic Tumor Ablation
Junjie Li,Anjaneyulu Dirisala,Zhishen Ge,Yuheng Wang,Wei Yin,Wendong Ke,Kazuko Toh,Jinbing Xie,Yu Matsumoto,Yasutaka Anraku,Kensuke Osada,Kazunori Kataoka +11 more
TL;DR: Novel glucose oxidase (GOD)-loaded therapeutic vesicular NRs (theraNR) are constructed based on a diblockCopolymer containing poly(ethylene glycol) (PEG) and copolymerized phenylboronic ester or piperidine-functionalized methacrylate (P(PBEM-co-PEM).