Q
Qixian Chen
Researcher at Dalian University of Technology
Publications - 99
Citations - 4347
Qixian Chen is an academic researcher from Dalian University of Technology. The author has contributed to research in topics: Gene delivery & Medicine. The author has an hindex of 25, co-authored 85 publications receiving 3526 citations. Previous affiliations of Qixian Chen include Chinese Academy of Sciences & The University of Nottingham Ningbo China.
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Journal ArticleDOI
Accumulation of sub-100 nm polymeric micelles in poorly permeable tumours depends on size
Horacio Cabral,Yu Matsumoto,Kazue Mizuno,Qixian Chen,Mami Murakami,M. Kimura,Yasuko Terada,Mitsunobu R. Kano,Kohei Miyazono,Mitsuru Uesaka,Nobuhiro Nishiyama,Kazunori Kataoka +11 more
TL;DR: It is shown that the penetration and efficacy of the larger micelles could be enhanced by using a transforming growth factor-β inhibitor to increase the permeability of the tumours.
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Janus "nano-bullets" for magnetic targeting liver cancer chemotherapy.
TL;DR: This study demonstrates an intriguing targeting strategy for liver cancer treatment based on a novel Janus nano-bullet, aiming for utilization of nanotechnology to obtain safe andcient treatment of liver cancer.
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Nitroxide-Based Macromolecular Contrast Agents with Unprecedented Transverse Relaxivity and Stability for Magnetic Resonance Imaging of Tumors
Hung V.-T. Nguyen,Qixian Chen,Joseph T. Paletta,Peter Harvey,Yivan Jiang,Hui Zhang,Michael D. Boska,M. Francesca Ottaviani,Alan Jasanoff,Andrzej Rajca,Jeremiah A. Johnson +10 more
TL;DR: Nitroxide-functionalized brush-arm star star polymer organic radical contrast agents (BASP-ORCAs) are the first nitroxide MRI contrast agents capable of tumor imaging over long time periods using clinical high-field 1H MRI techniques.
Journal ArticleDOI
Targeted gene delivery by polyplex micelles with crowded PEG palisade and cRGD moiety for systemic treatment of pancreatic tumors.
Zhishen Ge,Qixian Chen,Kensuke Osada,Kensuke Osada,Xueying Liu,Theofilus A. Tockary,Satoshi Uchida,Anjaneyulu Dirisala,Takehiko Ishii,Takahiro Nomoto,Kazuko Toh,Yu Matsumoto,Makoto Oba,Mitsunobu R. Kano,Keiji Itaka,Kazunori Kataoka +15 more
TL;DR: In this article, a cyclic RGD peptide as ligand molecule to integrin receptors was installed at the distal end of PEG in order for facilitating targeted delivery to the tumor site as well as promoting cellular uptake and intracellular trafficking behaviors.
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Pancreatic cancer therapy by systemic administration of VEGF siRNA contained in calcium phosphate/charge-conversional polymer hybrid nanoparticles
Frederico Pittella,Kanjiro Miyata,Yoshinori Maeda,Tomoya Suma,Sumiyo Watanabe,Qixian Chen,R. James Christie,Kensuke Osada,Nobuhiro Nishiyama,Kazunori Kataoka +9 more
TL;DR: Systemic administration of the nanoparticles carrying vascular endothelium growth factor (VEGF) siRNA led to the significant reduction in the subcutaneous BxPC3 tumor growth, well consistent with the enhanced accumulation of siRNA and the significant VEGF gene silencing in the tumor.