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Nolan Kamitaki
Researcher at Harvard University
Publications - 20
Citations - 13486
Nolan Kamitaki is an academic researcher from Harvard University. The author has contributed to research in topics: Gene & Complement component 4. The author has an hindex of 13, co-authored 17 publications receiving 10725 citations. Previous affiliations of Nolan Kamitaki include Broad Institute.
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Journal ArticleDOI
Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets
Evan Z. Macosko,Evan Z. Macosko,Anindita Basu,Anindita Basu,Rahul Satija,Rahul Satija,James Nemesh,James Nemesh,Karthik Shekhar,Melissa Goldman,Melissa Goldman,Itay Tirosh,Allison R. Bialas,Nolan Kamitaki,Nolan Kamitaki,Emily M. Martersteck,John J. Trombetta,David A. Weitz,Joshua R. Sanes,Alex K. Shalek,Alex K. Shalek,Alex K. Shalek,Aviv Regev,Aviv Regev,Aviv Regev,Steven A. McCarroll,Steven A. McCarroll +26 more
TL;DR: Drop-seq will accelerate biological discovery by enabling routine transcriptional profiling at single-cell resolution by separating them into nanoliter-sized aqueous droplets, associating a different barcode with each cell's RNAs, and sequencing them all together.
Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets
Evan Z. Macosko,Evan Z. Macosko,Anindita Basu,Anindita Basu,Rahul Satija,Rahul Satija,James Nemesh,James Nemesh,Karthik Shekhar,Melissa Goldman,Melissa Goldman,Itay Tirosh,Allison R. Bialas,Nolan Kamitaki,Nolan Kamitaki,Emily M. Martersteck,John J. Trombetta,David A. Weitz,Joshua R. Sanes,Alex K. Shalek,Alex K. Shalek,Alex K. Shalek,Aviv Regev,Aviv Regev,Aviv Regev,Steven A. McCarroll,Steven A. McCarroll +26 more
TL;DR: Drop-seq as discussed by the authors analyzes mRNA transcripts from thousands of individual cells simultaneously while remembering transcripts' cell of origin, and identifies 39 transcriptionally distinct cell populations, creating a molecular atlas of gene expression for known retinal cell classes and novel candidate cell subtypes.
Journal ArticleDOI
Schizophrenia risk from complex variation of complement component 4
Aswin Sekar,Aswin Sekar,Allison R. Bialas,Heather de Rivera,Heather de Rivera,Avery Davis,Avery Davis,Timothy R. Hammond,Nolan Kamitaki,Nolan Kamitaki,Katherine Tooley,Katherine Tooley,Jessy Presumey,Matthew A. Baum,Vanessa Van Doren,Giulio Genovese,Giulio Genovese,Samuel A. Rose,Robert E. Handsaker,Robert E. Handsaker,Mark J. Daly,Mark J. Daly,Michael C. Carroll,Beth Stevens,Beth Stevens,Steven A. McCarroll,Steven A. McCarroll +26 more
TL;DR: It is found that many structurally diverse alleles of the complement component 4 (C4) genes generated widely varying levels of C4A and C4B expression in the brain, with each common C4 allele associating with schizophrenia in proportion to its tendency to generate greater expression of C 4A.
Journal ArticleDOI
Molecular Diversity and Specializations among the Cells of the Adult Mouse Brain.
Arpiar Saunders,Arpiar Saunders,Evan Z. Macosko,Evan Z. Macosko,Alec Wysoker,Alec Wysoker,Melissa Goldman,Melissa Goldman,Fenna M. Krienen,Fenna M. Krienen,Heather de Rivera,Heather de Rivera,Elizabeth Bien,Elizabeth Bien,Matthew A. Baum,Matthew A. Baum,Laura Bortolin,Laura Bortolin,Shuyu Wang,Aleksandrina Goeva,James Nemesh,James Nemesh,Nolan Kamitaki,Nolan Kamitaki,Sara A. Brumbaugh,Sara A. Brumbaugh,David Kulp,David Kulp,Steven A. McCarroll,Steven A. McCarroll +29 more
TL;DR: Features of brain organization are revealed, including a gene-expression module for synthesizing axonal and presynaptic components, patterns in the co-deployment of voltage-gated ion channels, functional distinctions among the cells of the vasculature and specialization of glutamatergic neurons across cortical regions.
Journal ArticleDOI
Lymphatic and Other Vascular Malformative/Overgrowth Disorders Are Caused by Somatic Mutations in PIK3CA
Valerie L. Luks,Nolan Kamitaki,Matthew P. Vivero,Wibke Uller,Rashed Rab,Judith V.M.G. Bovée,Kristy L. Rialon,Carlos J. Guevara,Ahmad I. Alomari,Arin K. Greene,Steven J. Fishman,Harry P.W. Kozakewich,Reid A. Maclellan,John B. Mulliken,Reza Rahbar,Samantha A. Spencer,Cameron C. Trenor,Joseph Upton,David Zurakowski,Jonathan A. Perkins,Andrew L Kirsh,James T. Bennett,William B. Dobyns,Kyle C. Kurek,Matthew L. Warman,Matthew L. Warman,Matthew L. Warman,Steven A. McCarroll,Rudy Murillo +28 more
TL;DR: Most individuals from Boston Children's Hospital who had isolated LM or LM as part of a syndrome were somatic mosaic for PIK3CA mutations, with 5 specific PIK 3CA mutations accounting for ∼ 80% of cases.