Nono Ayivi-Guedehoussou

TL;DR: An initial version of a proteome-scale map of human binary protein–protein interactions is described, which increases by ∼70% the set of available binary interactions within the tested space and reveals more than 300 new connections to over 100 disease-associated proteins.

TL;DR: Two case-control studies of incident breast cancer indicate that the HMMR locus is associated with higher risk of breast cancer in humans, and this network shows higher connectivity than expected by chance, suggesting that its components function in biologically related pathways.

TL;DR: This work filtered previous interaction data sets and integrated them with WI-2007 to generate a high-confidence consolidated map, which allowed us to estimate the size of the worm interactome at ∼116,000 interactions, and shows the complementarity of distinct experimental approaches in predicting different functional relationships between genes or proteins.

TL;DR: It is shown that one of the DAF-7/TGF-beta signaling modifiers has functional homology to human SNO/SKI oncoproteins and that mutations at the corresponding genetic locus daf-5 confer defects in DAF