C
Conxi Lázaro
Researcher at Carlos III Health Institute
Publications - 273
Citations - 14817
Conxi Lázaro is an academic researcher from Carlos III Health Institute. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 60, co-authored 248 publications receiving 12617 citations. Previous affiliations of Conxi Lázaro include Dresden University of Technology & King's College London.
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Journal ArticleDOI
Network modeling links breast cancer susceptibility and centrosome dysfunction.
Miguel Angel Pujana,Jing-Dong J. Han,Lea M. Starita,Kristen N. Stevens,Muneesh Tewari,Jin Sook Ahn,Gad Rennert,Victor Moreno,Tomas Kirchhoff,Bert Gold,Volker Assmann,Wael M. ElShamy,Jean François Rual,Douglas A. Levine,Laura S. Rozek,Rebecca Gelman,Kristin C. Gunsalus,Roger A. Greenberg,Bijan Sobhian,Nicolas Bertin,Kavitha Venkatesan,Nono Ayivi-Guedehoussou,Xavier Solé,Pilar Hernández,Conxi Lázaro,Katherine L. Nathanson,Barbara L. Weber,Michael E. Cusick,David E. Hill,Kenneth Offit,David M. Livingston,Stephen B. Gruber,Jeffrey D. Parvin,Marc Vidal +33 more
TL;DR: Two case-control studies of incident breast cancer indicate that the HMMR locus is associated with higher risk of breast cancer in humans, and this network shows higher connectivity than expected by chance, suggesting that its components function in biologically related pathways.
Journal ArticleDOI
Association Between BRCA1 and BRCA2 Mutations and Survival in Women with Invasive Epithelial Ovarian Cancer
Kelly L. Bolton,Kelly L. Bolton,Georgia Chenevix-Trench,Cindy Goh,Siegal Sadetzki,Susan J. Ramus,Beth Y. Karlan,Diether Lambrechts,Evelyn Despierre,Daniel Barrowdale,Lesley McGuffog,Sue Healey,Douglas F. Easton,Olga M. Sinilnikova,Javier Benitez,María Jesús Gómez García,Susan L. Neuhausen,Mitchell H. Gail,Patricia Hartge,Susan Peock,Debra Frost,D. Gareth Evans,Rosalind A. Eeles,Andrew K. Godwin,Mary B. Daly,Ava Kwong,Ava Kwong,Edmond S. K. Ma,Conxi Lázaro,Ignacio Blanco,Marco Montagna,Emma D'Andrea,Maria Ornella Nicoletto,Sharon E. Johnatty,Susanne K. Kjaer,Allan Jensen,Estrid Høgdall,Ellen L. Goode,Brooke L. Fridley,Jennifer T. Loud,Mark H. Greene,Phuong L. Mai,Angela Chetrit,Flora Lubin,Galit Hirsh-Yechezkel,Gord Glendon,Irene L. Andrulis,Irene L. Andrulis,Amanda E. Toland,Leigha Senter,Martin Gore,Charlie Gourley,Caroline O. Michie,Honglin Song,Jonathan Tyrer,Alice S. Whittemore,Valerie McGuire,Weiva Sieh,Ulf Kristoffersson,Håkan Olsson,Åke Borg,Douglas A. Levine,Linda Steele,Mary S. Beattie,Salina Chan,Robert L. Nussbaum,Kirsten B. Moysich,Jenny Gross,Ilana Cass,Christine Walsh,Andrew J. Li,R.S. Leuchter,Ora Gordon,Montserrat Garcia-Closas,Simon A. Gayther,Stephen J. Chanock,Antonis C. Antoniou,Paul D.P. Pharoah +77 more
TL;DR: Among patients with invasive EOC, having a germline mutation in BRCA1 or BRC a2 was associated with improved 5-year overall survival and BRCa2 carriers had the best prognosis.
Journal ArticleDOI
Pathology of Breast and Ovarian Cancers among BRCA1 and BRCA2 Mutation Carriers: Results from the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA).
Nasim Mavaddat,Daniel Barrowdale,Irene L. Andrulis,Susan M. Domchek,Diana Eccles,Heli Nevanlinna,Susan J. Ramus,Amanda B. Spurdle,Mark E. Robson,Mark E. Sherman,Anna Marie Mulligan,Fergus J. Couch,Christoph Engel,Lesley McGuffog,Sue Healey,Olga M. Sinilnikova,Melissa C. Southey,Mary Beth Terry,David E. Goldgar,Frances P. O'Malley,Esther M. John,Ramunas Janavicius,Laima Tihomirova,Thomas Hansen,Finn Cilius Nielsen,Ana Osorio,Alexandra V. Stavropoulou,Javier Benitez,Siranoush Manoukian,Bernard Peissel,Monica Barile,Sara Volorio,Barbara Pasini,Riccardo Dolcetti,Anna Laura Putignano,Laura Ottini,Paolo Radice,Ute Hamann,Muhammad Usman Rashid,Frans B. L. Hogervorst,Mieke Kriege,Rob B. van der Luijt,Susan Peock,Debra Frost,D. Gareth Evans,Carole Brewer,Lisa Walker,Mark T. Rogers,Lucy Side,C. E. Houghton,Jo Ellen Weaver,Andrew K. Godwin,Rita K. Schmutzler,Barbara Wappenschmidt,Alfons Meindl,Karin Kast,Norbert Arnold,Dieter Niederacher,Christian Sutter,Helmut Deissler,Doroteha Gadzicki,Sabine Preisler-Adams,Raymonda Varon-Mateeva,Ines Schönbuchner,Heidrun Gevensleben,Dominique Stoppa-Lyonnet,Muriel Belotti,Laure Barjhoux,Claudine Isaacs,Beth N. Peshkin,Trinidad Caldés,Miguel De Al Hoya,Carmen Cañadas,Tuomas Heikkinen,Päivi Heikkilä,Kristiina Aittomäki,Ignacio Blanco,Conxi Lázaro,Joan Brunet,Bjarni A. Agnarsson,Adalgeir Arason,Rosa B. Barkardottir,Martine Dumont,Jacques Simard,Marco Montagna,Simona Agata,Emma D'Andrea,Max Yan,Stephen B. Fox,Timothy R. Rebbeck,Wendy S. Rubinstein,Nadine Tung,Judy Garber,Xianshu Wang,Zachary S. Fredericksen,Vernon S. Pankratz,Noralane M. Lindor,Csilla Szabo,Kenneth Offit,Rita A. Sakr,Mia M. Gaudet,Christian F. Singer,Muy Kheng Tea,Christine Rappaport,Phuong L. Mai,Mark H. Greene,Anna P. Sokolenko,Evgeny N. Imyanitov,Amanda E. Toland,Leigha Senter,Kevin Sweet,Mads Thomassen,Anne-Marie Gerdes,Torben A Kruse,Maria A. Caligo,Paolo Aretini,Johanna Rantala,Anna Von Wachenfeld,Karin M. Henriksson,Linda Steele,Susan L. Neuhausen,Robert L. Nussbaum,Mary S. Beattie,Kunle Odunsi,Lara Sucheston,Simon A. Gayther,Katherine L. Nathanson,Jenny Gross,Christine Walsh,Beth Y. Karlan,Georgia Chenevix-Trench,Douglas F. Easton,Antonis C. Antoniou +132 more
TL;DR: Pathologic characteristics of BRCA1 and BRCa2 tumors may be useful for improving risk-prediction algorithms and informing clinical strategies for screening and prophylaxis.
Journal ArticleDOI
Deletion of the late cornified envelope LCE3B and LCE3C genes as a susceptibility factor for psoriasis
Rafael de Cid,Eva Riveira-Muñoz,Patrick L.J.M. Zeeuwen,Jason Robarge,Wilson Liao,Emma N. Dannhauser,Emiliano Giardina,Philip E. Stuart,Rajan P. Nair,Cynthia Helms,Geòrgia Escaramís,Ester Ballana,Gemma Martin-Ezquerra,Martin den Heijer,Marijke Kamsteeg,Irma Joosten,Evan E. Eichler,Conxi Lázaro,Ramon M. Pujol,Lluís Armengol,Gonçalo R. Abecasis,James T. Elder,Giuseppe Novelli,John A.L. Armour,Pui-Yan Kwok,Anne M. Bowcock,Joost Schalkwijk,Xavier Estivill +27 more
TL;DR: LCE expression can be induced in normal epidermis by skin barrier disruption and is strongly expressed in psoriatic lesions, suggesting that compromised skin barrier function has a role in psoriasis susceptibility.
Journal ArticleDOI
Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk
Fergus J. Couch,Xianshu Wang,Lesley McGuffog,Andy C. H. Lee,Curtis Olswold,Karoline Kuchenbaecker,Penny Soucy,Zachary S. Fredericksen,Daniel Barrowdale,Joe Dennis,Mia M. Gaudet,Ed Dicks,Matthew L. Kosel,Sue Healey,Olga M. Sinilnikova,Adam M. Lee,Francois Bacot,Daniel Vincent,Frans B. L. Hogervorst,Susan Peock,Dominique Stoppa-Lyonnet,Anna Jakubowska,Paolo Radice,Rita K. Schmutzler,Susan M. Domchek,Marion Piedmonte,Christian F. Singer,Eitan Friedman,Mads Thomassen,Thomas Hansen,Susan L. Neuhausen,Csilla Szabo,Ignacio Blanco,Mark H. Greene,Beth Y. Karlan,Judy Garber,Catherine M. Phelan,Jeffrey N. Weitzel,Marco Montagna,Edith Olah,Irene L. Andrulis,Andrew K. Godwin,Drakoulis Yannoukakos,David E. Goldgar,Trinidad Caldés,Heli Nevanlinna,Ana Osorio,Mary Beth Terry,Mary B. Daly,Elizabeth J. van Rensburg,Ute Hamann,Susan J. Ramus,Amanda E. Toland,Maria A. Caligo,Olufunmilayo I. Olopade,Nadine Tung,Kathleen Claes,Mary S. Beattie,Melissa C. Southey,Evgeny N. Imyanitov,Marc Tischkowitz,Ramunas Janavicius,Esther M. John,Ava Kwong,Orland Diez,Judith Balmaña,Rosa B. Barkardottir,Banu Arun,Gad Rennert,Soo Hwang Teo,Patricia A. Ganz,Ian G. Campbell,Annemarie H. van der Hout,Carolien H.M. van Deurzen,Caroline Seynaeve,Encarna B. Gomez Garcia,Flora E. van Leeuwen,Hanne Meijers-Heijboer,Johannes J. P. Gille,Margreet G. E. M. Ausems,Marinus J. Blok,Marjolijn J. L. Ligtenberg,Matti A. Rookus,Peter Devilee,Senno Verhoef,Theo A. M. van Os,Juul T. Wijnen,Debra Frost,Steve Ellis,Elena Fineberg,Radka Platte,D. Gareth Evans,Louise Izatt,Rosalind A. Eeles,Julian Adlard,Diana Eccles,Jackie Cook,Carole Brewer,Fiona Douglas,Shirley Hodgson,Patrick J. Morrison,Lucy Side,Alan Donaldson,C. E. Houghton,Mark T. Rogers,Huw Dorkins,Jacqueline Eason,Helen Gregory,Emma McCann,Alex Murray,Alain Calender,Agnès Hardouin,Pascaline Berthet,Capucine Delnatte,Catherine Noguès,Christine Lasset,Claude Houdayer,Dominique Leroux,Etienne Rouleau,Fabienne Prieur,Francesca Damiola,Hagay Sobol,Isabelle Coupier,Laurence Venat-Bouvet,Laurent Castera,Marion Gauthier-Villars,Mélanie Léoné,Pascal Pujol,Sylvie Mazoyer,Yves-Jean Bignon,Elżbieta Złowocka-Perłowska,Jacek Gronwald,Jan Lubinski,Katarzyna Durda,Katarzyna Jaworska,Tomasz Huzarski,Amanda B. Spurdle,Alessandra Viel,Bernard Peissel,Bernardo Bonanni,Giulia Melloni,Laura Ottini,Laura Papi,Liliana Varesco,Maria Grazia Tibiletti,Paolo Peterlongo,Sara Volorio,Siranoush Manoukian,Valeria Pensotti,Norbert Arnold,Christoph Engel,Helmut Deissler,Dorothea Gadzicki,Andrea Gehrig,Karin Kast,Kerstin Rhiem,Alfons Meindl,Dieter Niederacher,Nina Ditsch,Hansjoerg Plendl,Sabine Preisler-Adams,Stefanie Engert,Christian Sutter,Raymonda Varon-Mateeva,Barbara Wappenschmidt,Bernhard H. F. Weber,Brita Arver,Marie Stenmark-Askmalm,Niklas Loman,Richard Rosenquist,Zakaria Einbeigi,Katherine L. Nathanson,Timothy R. Rebbeck,Stephanie V. Blank,David E. Cohn,Gustavo C. Rodriguez,Laurie Small,Michael Friedlander,Victoria L. Bae-Jump,Anneliese Fink-Retter,Christine Rappaport,Daphne Gschwantler-Kaulich,Georg Pfeiler,Muy-Kheng Tea,Noralane M. Lindor,Bella Kaufman,Shani Shimon Paluch,Yael Laitman,Anne-Bine Skytte,Anne-Marie Gerdes,Inge Søkilde Pedersen,Sanne Traasdahl Moeller,Torben A Kruse,Uffe Birk Jensen,Joseph Vijai,Kara Sarrel,Mark E. Robson,Noah D. Kauff,Anna Marie Mulligan,Gord Glendon,Hilmi Ozcelik,Bent Ejlertsen,Finn Cilius Nielsen,Lars Jønson,Mette K. Andersen,Yuan Chun Ding,Linda Steele,Lenka Foretova,Alex Teulé,Conxi Lázaro,Joan Brunet,Miquel Angel Pujana,Phuong L. Mai,Jennifer T. Loud,Christine Walsh,Jenny Lester,Sandra Orsulic,Steven A. Narod,Josef Herzog,Sharon Sand,Silvia Tognazzo,Simona Agata,Tibor Vaszko,JoEllen Weaver,Alexandra V. Stavropoulou,Saundra S. Buys,Atocha Romero,Miguel de la Hoya,Kristiina Aittomäki,Taru A. Muranen,Mercedes Durán,Wendy K. Chung,Adriana Lasa,Cecilia M. Dorfling,Alexander Miron,Javier Benitez,Leigha Senter,Dezheng Huo,Salina B. Chan,Anna P. Sokolenko,Jocelyne Chiquette,Laima Tihomirova,Tara M. Friebel,Bjarni A. Agnarsson,Karen H. Lu,Flavio Lejbkowicz,Paul A. James,Per Hall,Alison M. Dunning,Daniel C. Tessier,Julie M. Cunningham,Susan L. Slager,Chen Wang,Steven N. Hart,Kristen N. Stevens,Jacques Simard,Tomi Pastinen,Vernon S. Pankratz,Kenneth Offit,Douglas F. Easton,Georgia Chenevix-Trench,Antonis C. Antoniou +261 more
TL;DR: It is estimated that the breast cancer lifetime risks for the5% of BRCA1 carriers at lowest risk are 28%–50% compared to 81%–100% for the 5% at highest risk, and the ovarian cancer lifetime risk is 63% or higher, based on the known cancer risk-modifying loci.