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Christopher M. Armstrong
Researcher at Washington University in St. Louis
Publications - 20
Citations - 6345
Christopher M. Armstrong is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Acetylation & Nuclear protein. The author has an hindex of 15, co-authored 20 publications receiving 6009 citations. Previous affiliations of Christopher M. Armstrong include Harvard University & Case Western Reserve University.
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Journal ArticleDOI
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
TL;DR: The analysis of two SIR2 mutations supports the idea that this deacetylase activity accounts for silencing, recombination suppression and extension of life span in vivo, and provides a molecular framework of NAD-dependent histone de acetylation that connects metabolism, genomic silencing and ageing in yeast and, perhaps, in higher eukaryotes.
Journal ArticleDOI
A Map of the Interactome Network of the Metazoan C. elegans
Siming Li,Christopher M. Armstrong,Nicolas Bertin,Hui Ge,Stuart Milstein,Mike Boxem,Pierre-Olivier Vidalain,Jing-Dong J. Han,Alban Chesneau,Tong Hao,Debra S. Goldberg,Ning Li,Monica Martinez,Jean François Rual,Philippe Lamesch,Lai Xu,Lai Xu,Muneesh Tewari,Sharyl L. Wong,Lan V. Zhang,Gabriel F. Berriz,Laurent Jacotot,Philippe Vaglio,Jérôme Reboul,Tomoko Hirozane-Kishikawa,Qian-Ru Li,Harrison W. Gabel,Ahmed Elewa,Ahmed Elewa,Bridget L. Baumgartner,Debra J. Rose,Haiyuan Yu,Stephanie Bosak,Reynaldo Sequerra,Andrew G. Fraser,Susan E. Mango,William M. Saxton,Susan Strome,Sander van den Heuvel,Fabio Piano,Jean Vandenhaute,Claude Sardet,Mark Gerstein,Lynn Doucette-Stamm,Kristin C. Gunsalus,J. Wade Harper,J. Wade Harper,Michael E. Cusick,Frederick P. Roth,David E. Hill,Marc Vidal +50 more
TL;DR: A large fraction of the Caenorhabditis elegans interactome network is mapped, starting with a subset of metazoan-specific proteins, and more than 4000 interactions were identified from high-throughput, yeast two-hybrid screens.
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C. elegans ORFeome version 1.1: experimental verification of the genome annotation and resource for proteome-scale protein expression.
Jérôme Reboul,Philippe Vaglio,Jean François Rual,Jean François Rual,Philippe Lamesch,Philippe Lamesch,Monica Martinez,Christopher M. Armstrong,Siming Li,Laurent Jacotot,Nicolas Bertin,Rekin's Janky,Troy Moore,James R. Hudson,James L. Hartley,James L. Hartley,Michael A. Brasch,Jean Vandenhaute,Simon J. Boulton,Simon J. Boulton,Gregory A. Endress,Sarah Jenna,Eric Chevet,Vasilis Papasotiropoulos,Peter Tolias,Jason Ptacek,Michael Snyder,Raymond Y. Huang,Mark R. Chance,Hongmei Lee,Lynn Doucette-Stamm,David E. Hill,Marc Vidal +32 more
TL;DR: Gateway-clone all predicted protein-encoding open reading frames (ORFs), or the 'ORFeome,' of Caenorhabditis elegans successfully, and it is suggested that similar ORFeome projects will be valuable for other organisms, including humans.
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An FKBP destabilization domain modulates protein levels in Plasmodium falciparum
TL;DR: The swollen food vacuole phenotype of falcipain-2 knockout parasites could be rescued in a Shld1 ligand–dependent fashion by falcine-2–ddFKBP expression.
Journal ArticleDOI
Systematic Interactome Mapping and Genetic Perturbation Analysis of a C. elegans TGF-β Signaling Network
Muneesh Tewari,Patrick J. Hu,Jin Sook Ahn,Nono Ayivi-Guedehoussou,Pierre-Olivier Vidalain,Siming Li,Stuart Milstein,Christopher M. Armstrong,Mike Boxem,Maurice D. Butler,Svetlana Busiguina,Svetlana Busiguina,Jean François Rual,Nieves Ibarrola,Sabrina T. Chaklos,Sabrina T. Chaklos,Nicolas Bertin,Philippe Vaglio,Mark L. Edgley,Mark L. Edgley,Kevin V. King,Patrice S. Albert,Jean Vandenhaute,Akhilesh Pandey,Donald L Riddle,Gary Ruvkun,Marc Vidal +26 more
TL;DR: It is shown that one of the DAF-7/TGF-beta signaling modifiers has functional homology to human SNO/SKI oncoproteins and that mutations at the corresponding genetic locus daf-5 confer defects in DAF