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Norman M. Greenberg
Researcher at Fred Hutchinson Cancer Research Center
Publications - 27
Citations - 1743
Norman M. Greenberg is an academic researcher from Fred Hutchinson Cancer Research Center. The author has contributed to research in topics: Prostate cancer & Prostate. The author has an hindex of 23, co-authored 27 publications receiving 1648 citations. Previous affiliations of Norman M. Greenberg include University of Adelaide & University of Washington.
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Journal ArticleDOI
Androgen receptor coregulators and their involvement in the development and progression of prostate cancer
Ren ee Chmelar,Grant Buchanan,Eleanor F. Need,Wayne D. Tilley,Norman M. Greenberg,Norman M. Greenberg +5 more
TL;DR: The evidence for deregulated expression and function of the AR and associated coactivators and corepressors and how such events might contribute to the progression of prostate cancer by controlling the selection and expression of AR targets is reviewed.
Journal ArticleDOI
Targeting aurora kinases for the treatment of prostate cancer
Edmund Chun Yu Lee,Anna Frolov,Rile Li,Gustavo Ayala,Norman M. Greenberg,Norman M. Greenberg +5 more
TL;DR: A functional relationship between Aurora kinase expression and prostate cancer and the application of small-molecule inhibitors in therapeutic modalities is supported.
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Adoptive Transfer of Tumor-Reactive Transforming Growth Factor-β–Insensitive CD8+ T Cells: Eradication of Autologous Mouse Prostate Cancer
Qiang Zhang,Ximing J. Yang,Michael R. Pins,Borko Javonovic,Timothy M. Kuzel,Seong-Jin Kim,Luk Van Parijs,Norman M. Greenberg,Victoria Liu,Yinglu Guo,Chung Lee +10 more
TL;DR: The results suggest that adoptive transfer of tumor-reactive TGF-beta-insensitive CD8+ T cells may warrant consideration for cancer therapy.
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The current state of preclinical prostate cancer animal models.
Kenneth J. Pienta,Cory Abate-Shen,David B. Agus,Ricardo M. Attar,Leland W.K. Chung,Norman M. Greenberg,William C. Hahn,John T. Isaacs,Nora M. Navone,Donna M. Peehl,Jonathon W. Simons,David B. Solit,Howard R. Soule,Terry A. VanDyke,Michael J. Weber,Lily Wu,Robert L. Vessella +16 more
TL;DR: The PCMWG reviewed the state of prostate cancer preclinical models and identified the current limitations of cell line, xenograft and genetically engineered mouse models that have hampered the transition of scientific findings from these models to human clinical trials.
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Fibroblast growth factor receptor 2 tyrosine kinase is required for prostatic morphogenesis and the acquisition of strict androgen dependency for adult tissue homeostasis.
Yongshun Lin,Guoqin Liu,Yongyou Zhang,Ya-Ping Hu,Kai Yu,Chunhong Lin,Kerstin McKeehan,Jim W. Xuan,David M. Ornitz,Michael M. Shen,Norman M. Greenberg,Wallace L. McKeehan,Fen Wang +12 more
TL;DR: Fgfr2cn prostates provide a useful animal model for scrutinizing molecular mechanisms by which androgens regulate prostate growth, homeostasis and function, and may yield clues as to how advanced-tumor prostate cells escape strict androgen regulations.