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Numa R. Gottardi-Littell
Researcher at Northwestern University
Publications - 16
Citations - 1400
Numa R. Gottardi-Littell is an academic researcher from Northwestern University. The author has contributed to research in topics: Aneurysm & Cerebral angiography. The author has an hindex of 10, co-authored 16 publications receiving 1318 citations.
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Journal ArticleDOI
Progressive multifocal leukoencephalopathy after rituximab therapy in HIV-negative patients: a report of 57 cases from the Research on Adverse Drug Events and Reports project.
Kenneth R. Carson,Andrew M. Evens,Elizabeth A. Richey,Thomas M. Habermann,Daniele Focosi,John F. Seymour,Jacob P. Laubach,Susie D. Bawn,Leo I. Gordon,Jane N. Winter,Richard R. Furman,Julie M. Vose,Andrew D. Zelenetz,Andrew D. Zelenetz,Ronac Mamtani,Dennis W. Raisch,Gary W. Dorshimer,Steven T. Rosen,Kenji Muro,Numa R. Gottardi-Littell,Robert L. Talley,Oliver Sartor,David Green,Eugene O. Major,Charles L. Bennett,Charles L. Bennett +25 more
TL;DR: Overall, 52 patients with lymphoproliferative disorders, 2 patients with systemic lupus erythematosus, 1 patient with rheumatoid arthritis,1 patient with an idiopathic autoimmune pancytopenia, and 1 patientwith immune thrombocytopenIA developed PML after treatment with rituximab and other agents from 1997 to 2008.
Journal ArticleDOI
Differential Expression of Cholesterol Hydroxylases in Alzheimer's Disease*
James Brown,Catherine Theisler,Simone Silberman,Debra J. Magnuson,Numa R. Gottardi-Littell,John M. Lee,Debra Yager,Janet Crowley,Kumar Sambamurti,Mohammad M. Rahman,Allison B. Reiss,Christopher B. Eckman,Benjamin Wolozin +12 more
TL;DR: The selective expression of CYP46A1 around neuritic plaques and the potent inhibition of APP processing in neurons by 24(S)-hydroxycholesterol suggests that CYP 46A1 affects the pathophysiology of AD and provides insight into how polymorphisms in the CYP45A1 gene might influence the path physiology of this prevalent disease.
Journal ArticleDOI
Presenilins mutated at Asp-257 or Asp-385 restore Pen-2 expression and Nicastrin glycosylation but remain catalytically inactive in the absence of wild type Presenilin.
Omar Nyabi,Mostafa Bentahir,Katrien Horré,An Herreman,Numa R. Gottardi-Littell,Christine Van Broeckhoven,Pascal Gerard Merchiers,Kurt Spittaels,Wim Annaert,Bart De Strooper +9 more
TL;DR: It is demonstrated that the catalytic activity of Presenilin and its other functions in the generation, stabilization, and transport of the γ-secretase complex can be separated and extends the concept that PresenILins are multifunctional proteins.
Journal ArticleDOI
Bing-Neel syndrome: an illustrative case and a comprehensive review of the published literature.
Roneil G. Malkani,Martin S. Tallman,Numa R. Gottardi-Littell,William J. Karpus,Laura Marszalek,Daina Variakojis,Bruce Kaden,Matthew T. Walker,Robert M. Levy,Jeffrey J. Raizer +9 more
TL;DR: A Medline search using the terms “Waldenstrom’s macroglobulinemia and central nervous system” and “Bing–Neel” collecting data on presentation, evaluation, treatment, and outcome and summarizing these findings in the largest pooled series to date.
Journal ArticleDOI
Surgical Management of a Ruptured Posterior Choroidal Intraventricular Aneurysm Associated with Moyamoya Disease Using Frameless Stereotaxy: Case Report and Review of the Literature
M. Jafer Ali,Bernard R. Bendok,Christopher C. Getch,Numa R. Gottardi-Littell,Stefan A. Mindea,H. Hunt Batjer +5 more
TL;DR: The management of hemorrhagic moyamoya disease should be modified based on the source of hemorrhage and its relation to a specifically located aneurysm, and early intervention in treating ruptured intracranialAneurysms using the least invasive surgical techniques is recommended.