O
Ole Paulsen
Researcher at University of Cambridge
Publications - 147
Citations - 14496
Ole Paulsen is an academic researcher from University of Cambridge. The author has contributed to research in topics: Long-term potentiation & Synaptic plasticity. The author has an hindex of 60, co-authored 142 publications receiving 12881 citations. Previous affiliations of Ole Paulsen include University of Oslo & Norwegian University of Science and Technology.
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A comparison of computational methods for detecting bursts in neuronal spike trains and their application to human stem cell-derived neuronal networks
TL;DR: An unbiased quantitative assessment of eight existing methods for identifying bursts in neuronal spike trains is provided and recommendations for the best practice are provided for accurate identification of bursts using existing techniques.
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Induction and expression of GluA1 (GluR-A)-independent LTP in the hippocampus
Carola Romberg,Joel Raffel,Lucy Martin,Rolf Sprengel,Peter H. Seeburg,J. N. P. Rawlins,David M. Bannerman,Ole Paulsen +7 more
TL;DR: The findings support and extend the evidence that LTP at hippocampal CA3–CA1 synapses comprises a rapidly decaying, GluA1‐dependent component and a more sustained, GLUA 1‐independent component, induced and expressed via a separate mechanism involving GluN2B‐containing NMDA receptors, neuronal nitric oxide synthase and PKC.
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Transgenic Overexpression of the Type I Isoform of Neuregulin 1 Affects Working Memory and Hippocampal Oscillations but not Long-term Potentiation
Inga H. Deakin,Wiebke Nissen,Amanda J. Law,Tracy A. Lane,Riam Kanso,Markus H. Schwab,Klaus-Armin Nave,Karri Lamsa,Ole Paulsen,David M. Bannerman,Paul Harrison +10 more
TL;DR: Evidence is provided that NRG1 type I impacts on hippocampal function and circuitry, and the findings emphasize the complex and pleiotropic nature of the gene, even with regard to a single isoform.
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Mechanisms underlying gamma (‘40 Hz’) network oscillations in the hippocampus—a mini-review
TL;DR: This review provides an update on recent experiments addressing the mechanisms underlying gamma-frequency network oscillations in the rodent hippocampus, with particular emphasis on the correlation between in vivo observations and in vitro models.
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Archaerhodopsin Selectively and Reversibly Silences Synaptic Transmission through Altered pH
Mohamady El-Gaby,Yu Zhang,Konstantin Wolf,Christof J. Schwiening,Ole Paulsen,Olivia A. Shipton +5 more
TL;DR: It is shown that presynaptic expression of the proton pump archaerhodopsin enables robust, selective, and reversible optogenetic synaptic silencing with rapid onset and offset, and a requirement for CA3-CA1 synapses whose afferents originate from the left CA3, but not those from the rightCA3, for performance on a long-term memory task is uncovered.