O
Ole Paulsen
Researcher at University of Cambridge
Publications - 147
Citations - 14496
Ole Paulsen is an academic researcher from University of Cambridge. The author has contributed to research in topics: Long-term potentiation & Synaptic plasticity. The author has an hindex of 60, co-authored 142 publications receiving 12881 citations. Previous affiliations of Ole Paulsen include University of Oslo & Norwegian University of Science and Technology.
Papers
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Journal ArticleDOI
Early maturation and distinct tau pathology in induced pluripotent stem cell-derived neurons from patients with MAPT mutations
Mariangela Iovino,Sylvia Agathou,Ana González-Rueda,Martin Del Castillo Velasco-Herrera,Barbara Borroni,Antonella Alberici,Timothy Lynch,Seán O'Dowd,Imbisaat Geti,Daniel J. Gaffney,Ludovic Vallier,Ludovic Vallier,Ole Paulsen,Ragnhildur Thóra Káradóttir,Maria Grazia Spillantini +14 more
TL;DR: The previously unreported faster maturation of MAPT mutant human neurons, the developmental expression of 4R tau and the morphological alterations may contribute to disease development.
Journal ArticleDOI
Retroactive modulation of spike timing-dependent plasticity by dopamine
TL;DR: It is shown that dopamine, a positive reinforcement signal, can retroactively convert hippocampal timing-dependent synaptic depression into potentiation, and this finding identifies a biologically plausible mechanism for solving the ‘distal reward problem’.
Book ChapterDOI
The roles of GABAB receptors in cortical network activity.
Michael M. Kohl,Ole Paulsen +1 more
TL;DR: It is demonstrated how the slow time course of GABA(B) receptor-mediated inhibition is well suited to help mediate the slow oscillation, to modulate the power and spatial profile of gamma oscillations, and to moderate the relative spike timing of individual neurons during theta oscillations.
Journal ArticleDOI
Presynaptic Spike Timing-Dependent Long-Term Depression in the Mouse Hippocampus
TL;DR: The results show that CA3-CA1 synapses display both NMDA receptor-dependent t-LTP and t- lTD during development and identify a presynaptic form of hippocampal t- LTD similar to that previously described at neocortical synapses during development.
Journal ArticleDOI
Activity-Dependent Downscaling of Subthreshold Synaptic Inputs during Slow-Wave-Sleep-like Activity In Vivo
Ana González-Rueda,Ana González-Rueda,Victor Pedrosa,Victor Pedrosa,Rachael C. Feord,Claudia Clopath,Ole Paulsen +6 more
TL;DR: It is found that this novel activity-dependent and input-specific downscaling mechanism has two important computational advantages: improved signal-to-noise ratio, and preservation of previously stored information.