O
Ole Paulsen
Researcher at University of Cambridge
Publications - 147
Citations - 14496
Ole Paulsen is an academic researcher from University of Cambridge. The author has contributed to research in topics: Long-term potentiation & Synaptic plasticity. The author has an hindex of 60, co-authored 142 publications receiving 12881 citations. Previous affiliations of Ole Paulsen include University of Oslo & Norwegian University of Science and Technology.
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Roles of Presynaptic NMDA Receptors in Neurotransmission and Plasticity
TL;DR: The latest understanding of compartment-specific expression and function of preNMDARs are summarized, and how they contribute to synapse-specific and circuit-level information processing is summarized.
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Sequential neuromodulation of Hebbian plasticity offers mechanism for effective reward-based navigation.
TL;DR: It is demonstrated that sequential neuromodulation of STDP by acetylcholine and dopamine offers an efficacious model of reward-based navigation, and also provides a possible mechanism for aligning the time scales of cellular and behavioral learning.
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Identification of the current generator underlying cholinergically induced gamma frequency field potential oscillations in the hippocampal CA3 region
TL;DR: Analysis of the dynamics of the field potential presented here provides insight into the distinct contributions of synaptic and action currents to the EEG signal and sheds light on the changing balance of excitation and inhibition during cholinergically induced gamma frequency oscillations.
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Stem Cells Expanded from the Human Embryonic Hindbrain Stably Retain Regional Specification and High Neurogenic Potency
Jignesh Tailor,Raja Kittappa,Ketty Leto,Monte A. Gates,Melodie Borel,Ole Paulsen,Sonia Spitzer,Sonia Spitzer,Ragnhildur Thóra Káradóttir,Ragnhildur Thóra Káradóttir,Ferdinando Rossi,Anna Falk,Austin Smith +12 more
TL;DR: HbNES cells are the first demonstration of highly expandable neuroepithelial stem cells derived from the human embryo without genetic immortalization and provide a benchmark for the production of similar long-term neuroepIThelial-like stem cells (lt-NES) from pluripotent cell lines.
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Oscillatory Activity in the Medial Prefrontal Cortex and Nucleus Accumbens Correlates with Impulsivity and Reward Outcome
Nicholas A. Donnelly,Tahl Holtzman,P. Dylan Rich,P. Dylan Rich,Alejo J. Nevado-Holgado,Anushka B. P. Fernando,Gert van Dijck,Tobias Holzhammer,Oliver Paul,Patrick Ruther,Ole Paulsen,Trevor W. Robbins,Jeffrey W. Dalley +12 more
TL;DR: In a subgroup of rats showing persistently high levels of impulsivity, impulsivity was associated with increased error signals following a nose-poke response, as well as reduced signals of previous trial outcome during the waiting period, providing evidence that abnormalities in the encoding of rewarding outcomes may underlie trait-like impulsive behaviour.