O
Oleksandr Maximyuk
Researcher at National Academy of Sciences of Ukraine
Publications - 30
Citations - 394
Oleksandr Maximyuk is an academic researcher from National Academy of Sciences of Ukraine. The author has contributed to research in topics: Receptor & Patch clamp. The author has an hindex of 9, co-authored 27 publications receiving 298 citations. Previous affiliations of Oleksandr Maximyuk include Russian Academy.
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Journal ArticleDOI
Hyperforin attenuates various ionic conductance mechanisms in the isolated hippocampal neurons of rat
Shyam Sunder Chatterjee,V. M. Filippov,Polina V. Lishko,Oleksandr Maximyuk,Michael Nöldner,Oleg Krishtal +5 more
TL;DR: It is reconfirm that hyperforin is a major neuroactive component of hypericum extracts but also demonstrate that this structurally unique and naturally abundant molecule is a potent modulation of mechanism involved in the control of neuronal ionic conductances.
Journal ArticleDOI
Surface charge impact in low-magnesium model of seizure in rat hippocampus
Dmytro Isaev,Gleb Ivanchick,V. Khmyz,Elena Isaeva,Alina Savrasova,Oleg Krishtal,Gregory L. Holmes,Oleksandr Maximyuk +7 more
TL;DR: The results indicate that surface charge of the neuronal membrane plays a crucial role in the initiation of low Mg(2+)-induced seizures and suggests that Ca(2+) and Mg (2+), through screening of surface charge, have important anti-seizure and antiepileptic properties.
Journal ArticleDOI
P2X3 receptor gating near normal body temperature.
TL;DR: It is demonstrated directly that the desensitization of the receptor, after being activated by ATP, proceeds independently of the presence of agonist, causing unusual combination of temperature sensitivity/insensitivity of P2X3 receptors.
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Acid-sensing ion channel 1a contributes to hippocampal LTP inducibility through multiple mechanisms.
M. Liu,Hu Song Li,Wei Guang Li,Yan Jiao Wu,Shi Ning Deng,Chen Huang,Oleksandr Maximyuk,Volodymyr A. Sukach,Oleg Krishtal,Michael X. Zhu,Tian Le Xu +10 more
TL;DR: It is found that genetic deletion or pharmacological blockade of ASIC1a greatly reduced, but did not fully abolish, the probability of long-term potentiation (LTP) induction by either single or repeated high frequency stimulation or theta burst stimulation in the CA1 region.
Journal ArticleDOI
Novel Potent Orthosteric Antagonist of ASIC1a Prevents NMDAR-Dependent LTP Induction.
Andriy Z. Buta,Oleksandr Maximyuk,Dmytro Kovalskyy,Volodymyr A. Sukach,Mykhailo V. Vovk,Oleksandr Ievglevskyi,Elena Isaeva,Dmytro Isaev,Alina Savotchenko,Oleg Krishtal +9 more
TL;DR: Novel 2-oxo-2H-chromene-3-carboxamidine derivative 5b, designed with molecular modeling approach, inhibits ASIC1a currents with an apparent IC50 of 27 nM when measured at pH 6.7, and suggests that compound 5b binds to pH sensor of ASIC 1a acting as orthosteric noncompetitive antagonist.