O
Olena Morozova
Researcher at BC Cancer Agency
Publications - 24
Citations - 4451
Olena Morozova is an academic researcher from BC Cancer Agency. The author has contributed to research in topics: Neuroblastoma & Mutation. The author has an hindex of 17, co-authored 24 publications receiving 4043 citations. Previous affiliations of Olena Morozova include Howard Hughes Medical Institute & University of British Columbia.
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Journal ArticleDOI
Applications of next-generation sequencing technologies in functional genomics.
Olena Morozova,Marco A. Marra +1 more
TL;DR: This review discusses applications of next-generation sequencing technologies in functional genomics research and highlights the transforming potential these technologies offer.
Journal ArticleDOI
The genetic landscape of high-risk neuroblastoma
Trevor J. Pugh,Olena Morozova,Edward F. Attiyeh,Edward F. Attiyeh,Shahab Asgharzadeh,Shahab Asgharzadeh,Jun S. Wei,Daniel Auclair,Scott L. Carter,Kristian Cibulskis,Megan Hanna,Megan Hanna,Adam Kiezun,Jaegil Kim,Michael S. Lawrence,Lee Lichenstein,Aaron McKenna,Chandra Sekhar Pedamallu,Chandra Sekhar Pedamallu,Alex H. Ramos,Alex H. Ramos,Erica Shefler,Andrey Sivachenko,Carrie Sougnez,Chip Stewart,Adrian Ally,Inanc Birol,Readman Chiu,Richard Corbett,Martin Hirst,Shaun D. Jackman,Baljit Kamoh,Alireza Hadj Khodabakshi,Martin Krzywinski,Allan Lo,Richard A. Moore,Karen Mungall,Jenny Q. Qian,Angela Tam,Nina Thiessen,Yongjun Zhao,Kristina A. Cole,Kristina A. Cole,Maura Diamond,Maura Diamond,Sharon J. Diskin,Sharon J. Diskin,Yael P. Mosse,Yael P. Mosse,Andrew Wood,Andrew Wood,Lingyun Ji,Lingyun Ji,Richard Sposto,Richard Sposto,Thomas C. Badgett,Wendy B. London,Yvonne Moyer,Yvonne Moyer,Julie M. Gastier-Foster,Julie M. Gastier-Foster,Malcolm A. Smith,Jaime M. Guidry Auvil,Daniela S. Gerhard,Michael D. Hogarty,Michael D. Hogarty,Steven J.M. Jones,Eric S. Lander,Stacey Gabriel,Gad Getz,Robert C. Seeger,Robert C. Seeger,Javed Khan,Marco A. Marra,Matthew Meyerson,Matthew Meyerson,John M. Maris +76 more
TL;DR: The authors reported a low median exonic mutation frequency of 0.60 per Mb (0.48 nonsilent) and notably few recurrently mutated genes in high-risk neuroblastoma.
Journal ArticleDOI
Applications of New Sequencing Technologies for Transcriptome Analysis
TL;DR: Next-generation sequencing technologies have revolutionized transcriptomics by providing opportunities for multidimensional examinations of cellular transcriptomes in which high-throughput expression data are obtained at a single-base resolution.
Journal ArticleDOI
Recurrent activating ACVR1 mutations in diffuse intrinsic pontine glioma
Kathryn R. Taylor,Alan Mackay,Nathalene Truffaux,Yaron S. Butterfield,Olena Morozova,Olena Morozova,Cathy Philippe,David Castel,Catherine S. Grasso,Maria Vinci,Diana Carvalho,Angel M. Carcaboso,Carmen de Torres,Ofelia Cruz,Jaume Mora,Natacha Entz-Werle,Wendy J. Ingram,Michelle Monje,Darren Hargrave,Alex N. Bullock,Stéphanie Puget,Stephen Yip,Chris Jones,Jacques Grill +23 more
TL;DR: The identification of recurrent activating mutations in the ACVR1 gene, which encodes a type I activin receptor serine/threonine kinase, in 21% of DIPG samples are reported, which represent new targets for therapeutic intervention in this otherwise incurable disease.
Journal ArticleDOI
SKPs Derive from Hair Follicle Precursors and Exhibit Properties of Adult Dermal Stem Cells
Jeff Biernaskie,Maryline Paris,Olena Morozova,B. Matthew Fagan,Marco A. Marra,Larysa H. Pevny,Freda D. Miller +6 more
TL;DR: It is shown that skin-derived precursors (SKPs) derive from Sox2(+) hair follicle dermal cells and that these two cell populations are similar with regard to their transcriptome and functional properties.