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Xiao Liang
Researcher at Westlake University
Publications - 11
Citations - 1654
Xiao Liang is an academic researcher from Westlake University. The author has contributed to research in topics: Platelet degranulation & Biomarker discovery. The author has an hindex of 5, co-authored 11 publications receiving 969 citations. Previous affiliations of Xiao Liang include Free University of Berlin.
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Journal ArticleDOI
Proteomic and Metabolomic Characterization of COVID-19 Patient Sera.
Bo Shen,Xiao Yi,Yaoting Sun,Xiaojie Bi,Juping Du,Chao Zhang,Sheng Quan,Fangfei Zhang,Rui Sun,Liujia Qian,Weigang Ge,Wei Liu,Shuang Liang,Hao Chen,Ying Zhang,Jun Li,Jiaqin Xu,Zebao He,Baofu Chen,Jing Wang,Haixi Yan,Yufen Zheng,Donglian Wang,Jiansheng Zhu,Ziqing Kong,Zhouyang Kang,Xiao Liang,Xuan Ding,Guan Ruan,Nan Xiang,Xue Cai,Huanhuan Gao,Lu Li,Sainan Li,Qi Xiao,Tian Lu,Yi Zhu,Huafen Liu,Haixiao Chen,Tiannan Guo +39 more
TL;DR: This study revealed characteristic protein and metabolite changes in the sera of severe COVID-19 patients, which might be used in selection of potential blood biomarkers for severity evaluation.
Journal ArticleDOI
OpenMS: a flexible open-source software platform for mass spectrometry data analysis
Hannes L. Röst,Hannes L. Röst,Timo Sachsenberg,Stephan Aiche,Chris Bielow,Hendrik Weisser,Fabian Aicheler,Sandro Andreotti,Hans-Christian Ehrlich,Petra Gutenbrunner,Erhan Kenar,Xiao Liang,Sven Nahnsen,Lars Nilse,Julianus Pfeuffer,George Rosenberger,Marc Rurik,Uwe Schmitt,Johannes Veit,Mathias Walzer,David Wojnar,Witold Wolski,Oliver Schilling,Jyoti S. Choudhary,Lars Malmström,Lars Malmström,Ruedi Aebersold,Ruedi Aebersold,Knut Reinert,Knut Reinert,Oliver Kohlbacher +30 more
TL;DR: OpenMS 2.0 is presented, a robust, open-source, cross-platform software specifically designed for the flexible and reproducible analysis of high-throughput MS data.
Posted ContentDOI
Proteomic and Metabolomic Characterization of COVID-19 Patient Sera
Bo Shen,Xiao Yi,Yaoting Sun,Xiaojie Bi,Juping Du,Chao Zhang,Sheng Quan,Fangfei Zhang,Rui Sun,Liujia Qian,Weigang Ge,Wei Liu,Shuang Liang,Hao Chen,Ying Zhang,Jun Li,Jiaqin Xu,Zebao He,Baofu Chen,Jing Wang,Haixi Yan,Yufen Zheng,Donglian Wang,Jiansheng Zhu,Ziqing Kong,Zhouyang Kang,Xiao Liang,Xuan Ding,Guan Ruan,Nan Xiang,Xue Cai,Huanhuan Gao,Lu Li,Sainan Li,Qi Xiao,Tian Lu,Yi Zhu,Huafen Liu,Haixiao Chen,Tiannan Guo +39 more
TL;DR: This study shows that it is possible to predict progression to severe CO VID-19 disease using serum protein and metabolite biomarkers and uncovered molecular pathophysiology of COVID-19 with potential for developing anti-viral therapies.
Journal ArticleDOI
In-depth analysis of protein inference algorithms using multiple search engines and well-defined metrics.
Enrique Audain,Julian Uszkoreit,Timo Sachsenberg,Julianus Pfeuffer,Xiao Liang,Henning Hermjakob,Aniel Sanchez,Martin Eisenacher,Knut Reinert,David L. Tabb,Oliver Kohlbacher,Yasset Perez-Riverol +11 more
TL;DR: A new bioinformatics solution based on the KNIME/OpenMS platform that aims at providing a fair comparison of protein inference algorithms and examines how many proteins were reported by choosing each combination of search engines, protein inference algorithm, and parameters on each dataset.
Journal ArticleDOI
DPHL: A DIA Pan-human Protein Mass Spectrometry Library for Robust Biomarker Discovery
Tiansheng Zhu,Yi Zhu,Yue Xuan,Huanhuan Gao,Xue Cai,Sander R. Piersma,Thang V. Pham,Tim Schelfhorst,Richard R Goeij De Haas,Irene V. Bijnsdorp,Rui Sun,Liang Yue,Guan Ruan,Qiushi Zhang,Mo Hu,Yue Zhou,Winan J. van Houdt,Tessa Y S Le Large,Jacqueline Cloos,Anna Wojtuszkiewicz,Danijela Koppers-Lalic,Franziska Böttger,Chantal Scheepbouwer,Ruud H. Brakenhoff,Geert J.L.H. van Leenders,Jan N. M. IJzermans,John W.M. Martens,Renske D.M. Steenbergen,Nicole Cornelia Theodora van Grieken,Sathiyamoorthy Selvarajan,Sangeeta Mantoo,Sze S. Lee,Serene Jie Yi Yeow,Syed Muhammad Fahmy Alkaff,Nan Xiang,Yaoting Sun,Xiao Yi,Shaozheng Dai,Wei Liu,Tian Lu,Zhicheng Wu,Xiao Liang,Man Wang,Yingkuan Shao,Xi Zheng,Kailun Xu,Qin Yang,Yifan Meng,Cong Lu,Jiang Zhu,Jin’e Zheng,Bo Wang,Sai Lou,Yibei Dai,Chao Xu,Chenhuan Yu,Huazhong Ying,Tony Kiat Hon Lim,Jianmin Wu,Xiaofei Gao,Zhongzhi Luan,X D Teng,Peng Wu,Shiang Huang,Zhihua Tao,Narayanan G. Iyer,Shuigeng Zhou,Wenguang Shao,Henry H N Lam,Ding Ma,Jiafu Ji,Oi Lian Kon,Shu Zheng,Ruedi Aebersold,Connie R. Jimenez,Tiannan Guo +75 more
TL;DR: A MS pipeline and spectral resource to support targeted proteomics studies for human tissue samples and demonstrates that the DPHL supports DIA and PRM MS pipelines for robust protein biomarker discovery.