P
P. Britten Ventura
Researcher at University of Virginia
Publications - 4
Citations - 543
P. Britten Ventura is an academic researcher from University of Virginia. The author has contributed to research in topics: Gene & RNA extraction. The author has an hindex of 4, co-authored 4 publications receiving 412 citations. Previous affiliations of P. Britten Ventura include University of Oregon.
Papers
More filters
Journal ArticleDOI
Development of a method for the purification and culture of rodent astrocytes
Lynette C. Foo,Nicola J. Allen,Eric A. Bushong,P. Britten Ventura,Won-Suk Chung,Lu Zhou,John D. Cahoy,Richard Daneman,Hui Zong,Mark H. Ellisman,Ben A. Barres +10 more
TL;DR: It is found that some developing astrocytes normally undergo apoptosis in vivo and that the vast majority of astroCytes contact blood vessels, suggesting that astrocyts are matched to blood vessels by competing for vascular-derived trophic factors such as HBEGF.
Journal ArticleDOI
Mouse TU tagging: a chemical/genetic intersectional method for purifying cell type-specific nascent RNA
Michael R. Miller,P. Britten Ventura,Vidusha Devasthali,Zer Vue,Heather L. Thompson,Sally Temple,Hui Zong,Michael D. Cleary,Kryn Stankunas,Chris Q. Doe +9 more
TL;DR: TU tagging provides a novel method for identifying actively transcribed genes in specific cells at specific times within intact mice, and identifies immune versus niche spleen RNA.
Journal ArticleDOI
Astrocytic trans-Differentiation Completes a Multicellular Paracrine Feedback Loop Required for Medulloblastoma Tumor Growth.
Maojin Yao,P. Britten Ventura,Ying Jiang,Fausto J. Rodriguez,Lixin Wang,Justin S. A. Perry,Yibo Yang,Kelsey Wahl,Rowena B. Crittenden,Mariko L. Bennett,Lin Qi,Congcong Gong,Xiao-Nan Li,Ben A. Barres,Timothy P. Bender,Kodi S. Ravichandran,Kodi S. Ravichandran,Kevin A. Janes,Charles G. Eberhart,Hui Zong +19 more
TL;DR: An evolutionary process is revealed that produces a multi-lateral network within the TME of medulloblastoma: a fraction of tumor cells trans-differentiate into TuAstrocytes, which, in turn, produce IL-4 that stimulates microglia to produce IGF1 to promote tumor progression.
Journal ArticleDOI
MADM-ML, a mouse genetic mosaic system with increased clonal efficiency.
TL;DR: It is found that the new MADM-ML system, with its higher recombination efficiency, will broaden the applicability of MADM for studying many biological questions including normal development and disease modeling at cellular resolution in vivo.