P. Mainardi

TL;DR: The clinical studies have documented an association between alterations in gut microbiota composition and/or function, whereas the preclinical studies support a role for the gut microbiota in impacting behaviors which are of relevance to psychiatry and other central nervous system (CNS) disorders.

TL;DR: ALAC exerts significant protective activity against seizures in animal models, the effect being especially prominent against audiogenic seizures in GEPR-9 rats, seizures induced by low-dose pilocarpine in mice, and spontaneous seizures in mice exposed to piloc carpine-induced status epilepticus.

TL;DR: Reducing intestinal inflammation through ALAC or NaB administration has specific anticonvulsant effects in PTZ-treated mice, demonstrating that intestinal inflammation may represent a valid antiepileptic target which should also be considered as a participating factor to seizure incidence in susceptible patients and also could be relevant in reducing standard antIEpileptics.

TL;DR: ALAC showed protecting properties in both models of epileptogenesis, reducing spontaneous seizures development and antiseizure properties at some of the doses tested, and its effects are likely mediated by the inhibition of NMDA receptors at the glycine binding site.

TL;DR: It is suggested that LEG could contribute to the reconstitution of the GABA pool decreased by INH, as it inhibited either seizures or interictal spikes in both groups.