H
Hervé M. Blottière
Researcher at Université Paris-Saclay
Publications - 136
Citations - 12400
Hervé M. Blottière is an academic researcher from Université Paris-Saclay. The author has contributed to research in topics: Butyrate & Antigen. The author has an hindex of 43, co-authored 129 publications receiving 10046 citations. Previous affiliations of Hervé M. Blottière include Micalis Institute & Agro ParisTech.
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Journal ArticleDOI
Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients
Harry Sokol,Bénédicte Pigneur,Laurie Watterlot,Omar Lakhdari,Luis G. Bermúdez-Humarán,Jean-Jacques Gratadoux,Sébastien Blugeon,Chantal Bridonneau,Jean-Pierre Furet,Gérard Corthier,Corinne Grangette,Nadia Vasquez,Philippe Pochart,Germain Trugnan,Ginette Thomas,Hervé M. Blottière,Joël Doré,Philippe Marteau,Philippe Seksik,Philippe Langella +19 more
TL;DR: The results suggest that counterbalancing dysbiosis using F. prausnitzii as a probiotic is a promising strategy in CD treatment and exhibits anti-inflammatory effects on cellular and TNBS colitis models, partly due to secreted metabolites able to block NF-κB activation and IL-8 production.
Journal ArticleDOI
Butyrate inhibits inflammatory responses through NFκB inhibition: implications for Crohn's disease
Jean-Pierre Segain,D. Raingeard de la Blétière,Arnaud Bourreille,V. Leray,Nadine Gervois,Carlos Rosales,L Ferrier,C. Bonnet,Hervé M. Blottière,J. P. Galmiche +9 more
TL;DR: Butyrate decreases proinflammatory cytokine expression via inhibition of NFκB activation and IκBα degradation and these anti-inflammatory properties provide a rationale for assessing butyrate in the treatment of CD.
Journal Article
Akkermansia muciniphila and improved metabolic health during a dietary intervention in obesity : relationship with gut microbiome richness and ecology [plus Supplementary data]
Maria Carlota Dao,Amandine Everard,Judith Aron-Wisnewsky,Nataliya Sokolovska,Edi Prifti,Eric O. Verger,Brandon D. Kayser,Florence Levenez,Julien Chilloux,Lesley Hoyles,Marc E. Dumas,Salwa W. Rizkalla,Joël Doré,Patrice D. Cani,Karine Clément,S. Le Mouhaër,Aurélie Cotillard,Sean Kennedy,Nicolas Pons,Mathieu Almeida,Benoit Quinquis,Nathalie Galleron,Jean-Michel Batto,Pierre Renault,Jean-Daniel Zucker,S. Dusko Ehrlich,Hervé M. Blottière,Marion Leclerc,Catherine Juste,T. De Wouters,Patricia Lepage +30 more
TL;DR: In this paper, the authors evaluated the association between faecal A. muciniphila abundance and microbial gene richness after calorie restriction (CR) in overweight and obese adults.
Journal ArticleDOI
Energy balance and obesity: what are the main drivers?
Isabelle Romieu,Laure Dossus,Simón Barquera,Hervé M. Blottière,Paul W. Franks,Marc J. Gunter,Nahla Hwalla,Stephen D. Hursting,Michael F. Leitzmann,Barrie Margetts,Chizuru Nishida,Nancy Potischman,Jacob C. Seidell,Magdalena Stepien,Youfa Wang,Klaas R. Westerterp,Pattanee Winichagoon,Martin Wiseman,Walter C. Willett +18 more
TL;DR: Energy intake that exceeds energy expenditure is the main driver of weight gain and the quality of the diet may exert its effect on energy balance through complex hormonal and neurological pathways that influence satiety and possibly through other mechanisms.
Journal ArticleDOI
A metagenomic insight into our gut's microbiome
Patricia Lepage,Patricia Lepage,Marion Leclerc,Marion Leclerc,Marie Joossens,Marie Joossens,Stanislas Mondot,Hervé M. Blottière,Hervé M. Blottière,Jeroen Raes,Dusko Ehrlich,Dusko Ehrlich,Joël Doré,Joël Doré +13 more
TL;DR: The gene composition of human gut microbiome in a large and deeply sequenced cohort highlighted an overall non-redundant genome size 150 times larger than the human genome.