Journal ArticleDOI
Protective activity of α-lactoalbumin (ALAC), a whey protein rich in tryptophan, in rodent models of epileptogenesis
Emilio Russo,Francesca Scicchitano,Rita Citraro,Rossana Aiello,Caterina Camastra,P. Mainardi,Serafina Chimirri,Emilio Perucca,Giuseppe Donato,G. De Sarro +9 more
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TLDR
ALAC showed protecting properties in both models of epileptogenesis, reducing spontaneous seizures development and antiseizure properties at some of the doses tested, and its effects are likely mediated by the inhibition of NMDA receptors at the glycine binding site.About:
This article is published in Neuroscience.The article was published on 2012-12-13. It has received 32 citations till now. The article focuses on the topics: Glycine binding & Epileptogenesis.read more
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Applications for α-lactalbumin in human nutrition
TL;DR: Because of its physical characteristics, which include water solubility and heat stability, α-lactalbumin has the potential to be added to food products as a supplemental protein and has potential as a nutritional supplement to support neurological function and sleep in adults.
Journal ArticleDOI
Clinical applications of bioactive milk components
David R. Hill,David S. Newburg +1 more
TL;DR: Current efforts to translate the compounds derived from human and bovine milk into effective clinical therapies are summarized and a common pathway for the translation of milk-derived compounds into clinical applications is suggested.
Journal ArticleDOI
Early molecular and behavioral response to lipopolysaccharide in the WAG/Rij rat model of absence epilepsy and depressive-like behavior, involves interplay between AMPK, AKT/mTOR pathways and neuroinflammatory cytokine release
Emilio Russo,Francesco Andreozzi,Rodolfo Iuliano,Vincenzo Dattilo,Teresa Procopio,Giuseppe Fiume,Selena Mimmi,Nicola Perrotti,Rita Citraro,Giorgio Sesti,Andrew Constanti,Giovambattista De Sarro +11 more
TL;DR: It is confirmed that RAP inhibits the aggravation of absence seizures and depressive-like/sickness behavior induced by LPS in the WAG/Rij rats through the activation of mTOR and show that this effect is correlated with the ability of RAP to dampen and delay LPS increases in neuroinflammatory cytokines IL-1β and TNF-α, most likely through inhibition of theactivation of NF-κB.
Journal ArticleDOI
Protective effects of some statins on epileptogenesis and depressive‐like behavior in WAG/Rij rats, a genetic animal model of absence epilepsy
Rita Citraro,Serafina Chimirri,Rossana Aiello,Luca Gallelli,Francesca Trimboli,Domenico Britti,Giovambattista De Sarro,Emilio Russo +7 more
TL;DR: Both in vitro and in vivo studies have shown neuroprotective, antiseizure, and antiexcitotoxic effects of statins, suggesting their potential role in the treatment of neurologic diseases.
Journal ArticleDOI
CB1 agonists, locally applied to the cortico-thalamic circuit of rats with genetic absence epilepsy, reduce epileptic manifestations
Rita Citraro,Emilio Russo,Richard Teke Ngomba,Ferdinando Nicoletti,Francesca Scicchitano,Benjamin J. Whalley,Antonio Calignano,Giovambattista De Sarro +7 more
TL;DR: The results, together with previous reports, support therapeutic potential for endocannabinoid system modulators in absence epilepsy and highlight that attenuated endoc cannabinoidergic function may contribute to the generation and maintenance of seizures.
References
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Book
The Mouse Brain in Stereotaxic Coordinates
TL;DR: The 3rd edition of this atlas is now in more practical 14"x11" format for convenient lab use and includes a CD of all plates and diagrams, as well as Adobe Illustrator files of the diagrams, and a variety of additional useful material.
Journal ArticleDOI
The pilocarpine model of temporal lobe epilepsy.
TL;DR: It is proposed that the pilocarpine model can be a valuable tool to investigate the mechanisms involved in TLE, and even more so when standardized to reduce mortality at the time of pilocARPine injection, differences in latent period duration, variability in the lesion extent, and SRS frequency.
Journal ArticleDOI
Animal models of epilepsy for the development of antiepileptogenic and disease-modifying drugs. A comparison of the pharmacology of kindling and post-status epilepticus models of temporal lobe epilepsy.
TL;DR: A comparison of the pharmacology of chronic models with models of acute (reactive or provoked) seizures in previously healthy (non-epileptic) animals demonstrates that drug testing in chronic models of epilepsy yields data which are more predictive of clinical efficacy and adverse effects, so that chronic models should be used relatively early in drug development to minimize false positives.
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Prevention or Modification of Epileptogenesis after Brain Insults: Experimental Approaches and Translational Research
Wolfgang Löscher,Claudia Brandt +1 more
TL;DR: Two ongoing clinical trials will address the antiepileptogenic potential of topiramate and levetiracetam in patients with traumatic brain injury, hopefully translating laboratory discoveries into successful therapies.
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Serotonin and epilepsy
TL;DR: Imaging data and analysis of resected tissue of epileptic patients, and studies in animal models all provide evidence that endogenous 5‐HT, the activity of its receptors, and pharmaceuticals with serotonin agonist and/or antagonist properties play a significant role in the pathogenesis of epilepsies.