P
P. Mainardi
Researcher at University of Genoa
Publications - 26
Citations - 354
P. Mainardi is an academic researcher from University of Genoa. The author has contributed to research in topics: Neurotransmitter & Epilepsy. The author has an hindex of 9, co-authored 26 publications receiving 261 citations.
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Journal ArticleDOI
Microbiota-gut brain axis involvement in neuropsychiatric disorders
Luigi Francesco Iannone,Alberto Preda,Hervé M. Blottière,Gerard Clarke,Diego Albani,Vincenzo Belcastro,Marco Carotenuto,Annamaria Cattaneo,Rita Citraro,Cinzia Ferraris,Francesca Ronchi,Gaia Luongo,Elisa Santocchi,Letizia Guiducci,Pietro Baldelli,Paola Iannetti,Sigrid Pedersen,Andrea Petretto,Stefania Provasi,Kaja Kristine Selmer,Alberto Spalice,Anna Tagliabue,Alberto Verrotti,Nicola Segata,Jakob Zimmermann,Carlo Minetti,P. Mainardi,Carmen Giordano,Sanjay M. Sisodiya,Federico Zara,Emilio Russo,Pasquale Striano +31 more
TL;DR: The clinical studies have documented an association between alterations in gut microbiota composition and/or function, whereas the preclinical studies support a role for the gut microbiota in impacting behaviors which are of relevance to psychiatry and other central nervous system (CNS) disorders.
Journal ArticleDOI
Preclinical activity profile of α-lactoalbumin, a whey protein rich in tryptophan, in rodent models of seizures and epilepsy.
Rita Citraro,Francesca Scicchitano,Salvatore De Fazio,R. Raggio,P. Mainardi,Emilio Perucca,Giovambattista De Sarro,Emilio Russo +7 more
TL;DR: ALAC exerts significant protective activity against seizures in animal models, the effect being especially prominent against audiogenic seizures in GEPR-9 rats, seizures induced by low-dose pilocarpine in mice, and spontaneous seizures in mice exposed to piloc carpine-induced status epilepticus.
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Intestinal inflammation increases convulsant activity and reduces antiepileptic drug efficacy in a mouse model of epilepsy.
Carmen De Caro,Antonio Leo,Valentina Nesci,Carla Ghelardini,Lorenzo Di Cesare Mannelli,Pasquale Striano,Carmen Avagliano,Antonio Calignano,P. Mainardi,Andrew Constanti,Rita Citraro,Giovambattista De Sarro,Emilio Russo +12 more
TL;DR: Reducing intestinal inflammation through ALAC or NaB administration has specific anticonvulsant effects in PTZ-treated mice, demonstrating that intestinal inflammation may represent a valid antiepileptic target which should also be considered as a participating factor to seizure incidence in susceptible patients and also could be relevant in reducing standard antIEpileptics.
Journal ArticleDOI
Protective activity of α-lactoalbumin (ALAC), a whey protein rich in tryptophan, in rodent models of epileptogenesis
Emilio Russo,Francesca Scicchitano,Rita Citraro,Rossana Aiello,Caterina Camastra,P. Mainardi,Serafina Chimirri,Emilio Perucca,Giuseppe Donato,G. De Sarro +9 more
TL;DR: ALAC showed protecting properties in both models of epileptogenesis, reducing spontaneous seizures development and antiseizure properties at some of the doses tested, and its effects are likely mediated by the inhibition of NMDA receptors at the glycine binding site.
Journal ArticleDOI
Liposome‐Entrapped γ‐Aminobutyric Acid Inhibits Isoniazid‐Induced Epileptogenic Activity in Rats
Carlo Loeb,Gabriella Besio,P. Mainardi,P.A. Scotto,E. Benassi,Bo Gp,A. Portera Sanchez,D. Scheffner +7 more
TL;DR: It is suggested that LEG could contribute to the reconstitution of the GABA pool decreased by INH, as it inhibited either seizures or interictal spikes in both groups.