Pablo Tamayo

TL;DR: The data indicate high ATad2 expression is a marker of aggressive endometrial cancers, and suggest specific inhibitors of ATAD2 may have therapeutic utility in these and other MYC-dependent cancers.

TL;DR: A role for Tet genes and chromatin remodeling genes in the formation of cerebellar circuitry is demonstrated using metagene analysis and it is demonstrated that Knockdown of Tet1 and Tet3 by RNAi in ex vivo cerebellary slice cultures inhibits dendritic arborization of developing GCs, a critical step in circuit formation.

TL;DR: In this paper, a computational methodology for multiclass prediction that combines class-specific (one vs. all) binary support vector machines was proposed for the diagnosis of multiple common adult malignancies using DNA microarray data.

TL;DR: A transcriptional signature from the peripheral blood of MS patients may be able to help identify individuals who are more likely to relapse when treated with first-line MS drugs and could become part of a tool to help neurologists identify those MS patients at higher risk of attacks.

TL;DR: Cl similarity weighted nonnegative embedding (SWNE) is developed, which enhances interpretation of datasets by embedding the genes and factors that separate cell states on the visualization alongside the cells and maintains fidelity when visualizing local and global structure for both developmental trajectories and discrete cell types.