Pablo Tamayo

TL;DR: It is shown that the suppression of CDK8 expression inhibits proliferation in colon cancer cells characterized by high levels ofCDK8 and β-catenin hyperactivity, suggesting that therapeutic interventions targeting CDK 8 may confer a clinical benefit in β-Catenin-driven malignancies.

TL;DR: It is shown that a previously unidentified molecular subgroup, characterized genetically by c-MYC copy number gains and transcriptionally by enrichment of photoreceptor pathways and increased miR-183∼96∼182 expression, is associated with significantly lower rates of event-free and overall survivals.

TL;DR: In this article, the authors used high-throughput RNA interference (RNAi) to identify synthetic lethal interactions in cancer cells harboring mutant KRAS, the most commonly mutated human oncogene, and demonstrate the potential of RNAi screens for discovering functional dependencies created by oncogenic mutations that may enable therapeutic intervention for cancers with "undruggable" genetic alterations.

TL;DR: The spectrum of outcomes observed here and their association with CLOVAR signatures suggests variations in underlying tumor biology, which may provide a rationale for optimal combination of patient and treatment regimens.

TL;DR: An enterprise-wide web data mining system, computer program product, and method of operation thereof, that uses Internet based data sources, and which operates in an automated and cost effective manner is described in this article.