P
Pablo Tamayo
Researcher at University of California, San Diego
Publications - 185
Citations - 117545
Pablo Tamayo is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Cancer & Gene. The author has an hindex of 72, co-authored 177 publications receiving 97318 citations. Previous affiliations of Pablo Tamayo include University of California, Berkeley & Harvard University.
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Proceedings ArticleDOI
Abstract 4868: Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations within a wide spectrum of genetic heterogeneity
Trevor J. Pugh,Yoon Jae Cho,Tenley C. Archer,Dilhan Weeraratne,David T.W. Jones,Natalie Jaeger,Daniel Auclair,Kristian Cibulskis,Michael S. Lawrence,Alex H. Ramos,Erica Shefler,Andrey Sivachenko,Pablo Tamayo,Jill P. Mesirov,Stacey Gabriel,Gad Getz,Stefan M. Pfister,Peter Lichter,Matthew Meyerson,Scott L. Pomeroy +19 more
TL;DR: The diversity of somatic mutation in medulloblastoma, even within copy number subtypes, is demonstrated, as several genes are mutated across subtypes and several clustered within subtypes.
Journal ArticleDOI
Cyclin E Overexpression in Human Mammary Epithelial Cells Promotes Epithelial Cancer-Specific Copy Number Alterations.
TL;DR: It is shown that non-transformed human mammary epithelial cell clones that survive such aberrant mitoses have a specific and reproducible pattern of chromosomal Copy Number Alterations (CNAs) that is characterized and termed the cyclin E CNA signature.
DiSCoVERing Innovative Therapies for Rare Tumors: Combining Genetically Accurate Disease Models with In Silico Analysis to Identify Novel Therapeutic Targets
Allison Hanaford,Antoinette Price,Ulf Dietrich Kahlert,Jaroslaw Maciaczyk,Guido Nikkhah,Vlado Dančík,Brinton Seashore-Ludlow,Vasanthi Viswanathan,Matthew G. Rees,Charles G. Eberhart,Eric H. Raabe,Tenley C. Archer,Jong Wook Kim,Tobias Ehrenberger,Paul A. Clemons,Michelle Stewart,Alykhan F. Shamji,Stuart L. Schreiber,Ernest Fraenkel,Scott L. Pomeroy,Jill P. Mesirov,Pablo Tamayo +21 more
TL;DR: In this paper, the authors used human stem and progenitor cells derived from the cerebellar anlage to develop a genetically accurate novel model of myc-driven Group 3 medulloblastoma.
Posted ContentDOI
Visualizing single-cell RNA-seq datasets with Similarity Weighted Nonnegative Embedding (SWNE)
Yan Wu,Pablo Tamayo,Kun Zhang +2 more
TL;DR: This work developed a method for visualization and interpretation of scRNA-seq datasets, Similarity Weighted Nonnegative Embedding (SWNE), which captures both the global and local structure of the data, and embeds biological information directly onto the visualization.
Posted ContentDOI
A method for downstream analysis of gene set enrichment results facilitates the biological interpretation of vaccine efficacy studies
TL;DR: LEM analysis can significantly reduce the dimensionality of enriched gene sets, improve the identification of core biological processes active in a comparison of interest, and simplify the biological interpretation of GSEA results.