L
Linda Ottoboni
Researcher at Vita-Salute San Raffaele University
Publications - 43
Citations - 4393
Linda Ottoboni is an academic researcher from Vita-Salute San Raffaele University. The author has contributed to research in topics: Multiple sclerosis & Medicine. The author has an hindex of 22, co-authored 35 publications receiving 3919 citations. Previous affiliations of Linda Ottoboni include Harvard University & Massachusetts Institute of Technology.
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Journal ArticleDOI
Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci
Philip L. De Jager,Philip L. De Jager,Xiaoming Jia,Joanne Wang,Paul I.W. de Bakker,Linda Ottoboni,Linda Ottoboni,Neelum T. Aggarwal,Laura Piccio,Soumya Raychaudhuri,Dong Tran,Cristin Aubin,Rebeccah Briskin,Susan Romano,Sergio E. Baranzini,Jacob L. McCauley,Margaret A. Pericak-Vance,Jonathan L. Haines,Rachel A. Gibson,Yvonne Naeglin,Bernard M. J. Uitdehaag,Paul M. Matthews,Ludwig Kappos,Chris H. Polman,Wendy L. McArdle,David P. Strachan,Denis A. Evans,Anne H. Cross,Mark J. Daly,Alastair Compston,Stephen Sawcer,Howard L. Weiner,Stephen L. Hauser,David A. Hafler,David A. Hafler,Jorge R. Oksenberg +35 more
TL;DR: It is reported that the susceptibility allele near IRF8, which encodes a transcription factor known to function in type I Interferon signaling, is associated with higher mRNA expression of interferon-response pathway genes in subjects with MS.
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Neurosphere-derived multipotent precursors promote neuroprotection by an immunomodulatory mechanism.
Stefano Pluchino,Lucia Zanotti,Barbara Rossi,Elena Brambilla,Linda Ottoboni,Giuliana Salani,Marianna Martinello,Alessandro Cattalini,Alessandra Bergami,Roberto Furlan,Giancarlo Comi,Gabriela Constantin,Gianvito Martino +12 more
TL;DR: The results indicate that undifferentiated adult NPCs have relevant therapeutic potential in chronic inflammatory CNS disorders because they display immune-like functions that promote long-lasting neuroprotection.
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CD33 Alzheimer’s disease locus: Altered monocyte function and amyloid biology
Elizabeth M. Bradshaw,Lori B. Chibnik,Brendan T. Keenan,Brendan T. Keenan,Linda Ottoboni,Towfique Raj,Anna Tang,Anna Tang,Laura Rosenkrantz,Laura Rosenkrantz,Selina Imboywa,Selina Imboywa,Michelle Lee,Alina Von Korff,Martha Clare Morris,Denis A. Evans,Keith A. Johnson,Reisa A. Sperling,Julie A. Schneider,David A. Bennett,Philip L. De Jager,Philip L. De Jager +21 more
TL;DR: In the authors' functional dissection of the CD33 Alzheimer's disease susceptibility locus, it was found that the rs3865444C risk allele was associated with greater cell surface expression of CD33 in the monocytes of young and older individuals.
Journal ArticleDOI
A role for leukocyte-endothelial adhesion mechanisms in epilepsy
Paolo F. Fabene,Graciela Navarro Mora,Marianna Martinello,Barbara Rossi,Flavia Merigo,Linda Ottoboni,Simona Bach,Stefano Angiari,Donatella Benati,Asmaa Chakir,Lara Zanetti,Federica Schio,Antonio Marco Maria Osculati,Pasquina Marzola,Elena Nicolato,Jonathon W. Homeister,Lijun Xia,John B. Lowe,Rodger P. McEver,Francesco Osculati,Andrea Sbarbati,Eugene C. Butcher,Eugene C. Butcher,Gabriela Constantin +23 more
TL;DR: Leukocyte-endothelial interaction is suggested as a potential target for the prevention and treatment of epilepsy by showing that seizures induce elevated expression of vascular cell adhesion molecules and enhanced leukocytes rolling and arrest in brain vessels mediated by the leukocyte mucin P-selectin glycoprotein ligand-1.
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RhoA and ζ PKC Control Distinct Modalities of LFA-1 Activation by Chemokines: Critical Role of LFA-1 Affinity Triggering in Lymphocyte In Vivo Homing
Cinzia Giagulli,Elio Scarpini,Linda Ottoboni,Shuh Narumiya,Eugene C. Butcher,Eugene C. Butcher,Gabriela Constantin,Carlo Laudanna +7 more
TL;DR: RhoA controls the induction of LFA-1 high-affinity state by chemokines independently of zeta PKC, and this is critical to support chemokine-regulated homing of circulating lymphocytes.